DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpr16 and KIRREL2

DIOPT Version :9

Sequence 1:	NP_001287169.1	Gene:	dpr16 / 40619	FlyBaseID:	FBgn0037295	Length:	488	Species:	Drosophila melanogaster
Sequence 2:	NP_954649.3	Gene:	KIRREL2 / 84063	HGNCID:	18816	Length:	708	Species:	Homo sapiens

Alignment Length:	298	Identity:	64/298 - (21%)
Similarity:	93/298 - (31%)	Gaps:	95/298 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   205 PLNATVQAGQHAYLPCKLNQHSGKPLSWVRLRDEHIIAVDHTTFINDARFASLLQSTTLTTLVSG 269
            |.:..|..|:.|.|||.|..:.|. :.|.:                                 ||
Human    30 PEDLVVLLGEEARLPCALGAYWGL-VQWTK---------------------------------SG 60

  Fly   270 GALSTTATPVAALGNSFAHAVPGGQE----------RGNSSSLSWTLQIKYVNLEDAGWYECQLA 324
            .||                   |||.          .||:::....|.|:.|.|||...||||..
Human    61 LAL-------------------GGQRDLPGWSRYWISGNAANGQHDLHIRPVELEDEASYECQAT 106

  Fly   325 TEPKMSAKVQLFVITP--RTELIGDRQRFVKAGSRVELHCIVRGTLEAPKYIFWYRGDQQVTAEN 387
            .....|...||.|:.|  ..:::|.....:.||....|.|..||.......:.|:|..
Human   107 QAGLRSRPAQLHVLVPPEAPQVLGGPSVSLVAGVPANLTCRSRGDARPTPELLWFRDG------- 164

  Fly   388 EASGAQSGWYTQIDRNIFGSTEHNRNTIGSL--VIPLVRKIH--SGNYTCEPENSAAASMQ--LH 446
                      ..:|...|..|.....|.||:  .:.|....|  ...:.|...:.|..:.:  ..
Human   165 ----------VLLDGATFHQTLLKEGTPGSVESTLTLTPFSHDDGATFVCRARSQALPTGRDTAI 219

  Fly   447 VLSGEYSASAIKSTAARPHRLGHGYTSLHQWLIFLLVA 484
            .||.:|....  :.:|.||.:..|     :.:|||..|
Human   220 TLSLQYPPEV--TLSASPHTVQEG-----EKVIFLCQA 250

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr16	NP_001287169.1	IG_like	205..337	CDD:214653	32/141 (23%)
		Ig	<298..338	CDD:299845	14/39 (36%)
		IG_like	352..447	CDD:214653	18/100 (18%)
		Ig	358..439	CDD:143165	15/84 (18%)
KIRREL2	NP_954649.3	IG_like	30..119	CDD:214653	32/141 (23%)
		IGc2	38..106	CDD:197706	27/120 (23%)
		I-set	126..224	CDD:254352	21/114 (18%)
		Ig2_KIRREL3-like	141..223	CDD:143236	17/98 (17%)
		Cell attachment site. /evidence=ECO:0000255	149..151		1/1 (100%)
		Ig	231..306	CDD:299845	8/25 (32%)
		IG_like	234..308	CDD:214653	7/22 (32%)
		Ig	312..395	CDD:299845
		I-set	317..395	CDD:254352
		Ig	397..501	CDD:299845
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	545..601
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900