DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpr16 and robo4

DIOPT Version :9

Sequence 1:	NP_001287169.1	Gene:	dpr16 / 40619	FlyBaseID:	FBgn0037295	Length:	488	Species:	Drosophila melanogaster
Sequence 2:	XP_689255.3	Gene:	robo4 / 560765	ZFINID:	ZDB-GENE-020809-1	Length:	1134	Species:	Danio rerio

Alignment Length:	425	Identity:	89/425 - (20%)
Similarity:	140/425 - (32%)	Gaps:	149/425 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   165 PNEQSRLHAYDSEQKAQ-QLRREKELAKERELLPRR-------QLSLP-----PLNATVQAGQHA 216
            |:||.   |..||.|.. :.|...:.|..|:...||       :::||     |.:..|:.|..|
Zfish    27 PDEQV---AQRSEGKGHLRHRLMHQRASHRDRAHRRKGSRLVSEINLPRIVHHPSDVVVRVGSPA 88

  Fly   217 YLPCKLNQHSGKPLSWVR-----------LRDEHIIAVDHTTFI-----------NDARFASLLQ 259
            .|.|:...:....:.|:|           .:.:.|:..|.:.|.           ::|.:|.:..
Zfish    89 TLSCRAEGNPEPTIQWLRNGQPLDTDKMDAQSQPIVLPDGSLFFFSVVPGRKGQSHEAVYACIAH 153

  Fly   260 STTLTTLVSGGALSTTAT-PVAALGNSF-----------------------AHAVPGGQERG--- 297
            ::.      |.|.|..|: .:|||...|                       .|..|....|.
Zfish   154 NSI------GNATSRNASLHIAALREDFRVQPSDVEVAIGEMATINCSPPVGHPEPNVTWRKDGI 212

  Fly   298 --NSSSLSWT-----LQIKYVNLEDAGWYEC----QLATEPKMSAKVQLF---VITPRTELIGDR 348
              |||:..:|     |.|......|:|.|.|    .:......:|::.:.   |:..:.|.:.
Zfish   213 LINSSNEHYTELKGKLIIAPAQKNDSGVYSCIASNMIGVRESRAARLSVLAKPVLLRKPEDVS-- 275

  Fly   349 QRFVKAGSRVELHCIVRGTLEAPKYIFWYRGDQQVTAENEASGAQSGWYTQIDRNIFGSTEHNRN 413
               |:.|...:..|...|  :....|.|.|         |.....:|.|       ..:.:|
Zfish   276 ---VQLGESAQFFCEADG--DPMPSIEWSR---------EQGPLPNGRY-------LINPDH--- 316

  Fly   414 TIGSLVIPLVRKIHSGNYTCEPENS---AAASMQLHV----------LSGEYSA-------SAIK 458
               ||.|..|.....|.|:|..||.   :.||.||.|          |..|.||       ..:.
Zfish   317 ---SLQIHYVTAQDMGRYSCTVENKLGVSVASAQLLVEDAGGTRLRDLHKELSALRVSLENVTVM 378

  Fly   459 STA--------------ARPHRLGHGYTSLHQWLI 479
            |||              ::||.| .|:..|::.|:
Zfish   379 STASNMSQVMWKLQSFGSQPHYL-EGFEVLYRSLL 412

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr16	NP_001287169.1	IG_like	205..337	CDD:214653	35/194 (18%)
		Ig	<298..338	CDD:299845	11/51 (22%)
		IG_like	352..447	CDD:214653	24/97 (25%)
		Ig	358..439	CDD:143165	18/83 (22%)
robo4	XP_689255.3	Ig1_Robo	70..169	CDD:143317	19/104 (18%)
		I-set	71..168	CDD:254352	18/102 (18%)
		I-set	175..261	CDD:254352	15/85 (18%)
		Ig2_Robo	177..261	CDD:143201	14/83 (17%)
		I-set	265..350	CDD:254352	26/113 (23%)
		Ig	282..350	CDD:299845	22/91 (24%)
		FN3	373..448	CDD:214495	9/41 (22%)
		FN3	472..560	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900