DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpr16 and KIRREL1

DIOPT Version :9

Sequence 1:	NP_001287169.1	Gene:	dpr16 / 40619	FlyBaseID:	FBgn0037295	Length:	488	Species:	Drosophila melanogaster
Sequence 2:	XP_005245362.1	Gene:	KIRREL1 / 55243	HGNCID:	15734	Length:	773	Species:	Homo sapiens

Alignment Length:	294	Identity:	73/294 - (24%)
Similarity:	103/294 - (35%)	Gaps:	84/294 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   200 QLSLPPLNATVQAGQHAYLPCKLNQHSGKPLSWVRLRDEHIIAVDHTTFINDARFASLLQSTTLT 264
            :.|..|.:.||.|||.|.|||.|..:|| .:.|                             |..
Human    22 RFSQEPADQTVVAGQRAVLPCVLLNYSG-IVQW-----------------------------TKD 56

  Fly   265 TLVSGGALSTTATPVAALGNSFAHAVPGGQERGNSSSLSWTLQIKYVNLEDAGWYECQLATEPKM 329
            .|..|......|.|        .:.|.|..:.|     .:.|:|....|.|...|||| |||..:
Human    57 GLALGMGQGLKAWP--------RYRVVGSADAG-----QYNLEITDAELSDDASYECQ-ATEAAL 107

  Fly   330 -SAKVQLFVITP--RTELIGDRQRFVKAGSRVELHCIVRGTLEAPKYIFWYR-GDQQVTAENEAS 390
             |.:.:|.|:.|  .|.:.|.....::||:...|.|.......|.. |.|:| |.||       .
Human   108 RSRRAKLTVLIPPEDTRIDGGPVILLQAGTPHNLTCRAFNAKPAAT-IIWFRDGTQQ-------E 164

  Fly   391 GAQSGWYTQIDRNIFGSTEHNRNTIGSLVIPLVRKIHSGNYTCEPENSAAAS-------MQLH-- 446
            ||.:.  |::.::  |..|   .|:..|:|..........:||...|.|..|       :.:|
Human   165 GAVAS--TELLKD--GKRE---TTVSQLLINPTDLDIGRVFTCRSMNEAIPSGKETSIELDVHHP 222

  Fly   447 -----------VLSGEYSASAIKSTAARPHRLGH 469
                       |..||......::| |.|..||:
Human   223 PTVTLSIEPQTVQEGERVVFTCQAT-ANPEILGY 255

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr16	NP_001287169.1	IG_like	205..337	CDD:214653	35/132 (27%)
		Ig	<298..338	CDD:299845	13/40 (33%)
		IG_like	352..447	CDD:214653	25/115 (22%)
		Ig	358..439	CDD:143165	20/81 (25%)
KIRREL1	XP_005245362.1	I-set	22..116	CDD:254352	36/137 (26%)
		Ig	25..116	CDD:299845	35/134 (26%)
		Ig2_KIRREL3-like	138..219	CDD:143236	22/95 (23%)
		I-set	223..304	CDD:254352	8/34 (24%)
		Ig_2	227..305	CDD:290606	8/30 (27%)
		Ig_2	311..405	CDD:290606
		IG_like	314..405	CDD:214653
		Ig5_KIRREL3	407..504	CDD:143306
		IG_like	416..504	CDD:214653
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810