DRSC/TRiP Functional Genomics Resources

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Protein Alignment dpr16 and SDK2

DIOPT Version :9

Sequence 1:NP_001287169.1 Gene:dpr16 / 40619 FlyBaseID:FBgn0037295 Length:488 Species:Drosophila melanogaster
Sequence 2:NP_001138424.1 Gene:SDK2 / 54549 HGNCID:19308 Length:2172 Species:Homo sapiens


Alignment Length:331 Identity:79/331 - (23%)
Similarity:118/331 - (35%) Gaps:107/331 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly   203 LPPLNATVQAG-QHAYLPCKLNQHSGKPLSWVRLRDEHII-----------AVDHTTFI------ 249
            :||.|.:|.|| ....|.|..|   .:||  ::|   |||           ..||...:      
Human   219 IPPKNTSVVAGTSEVTLECVAN---ARPL--IKL---HIIWKKDGVLLSGGISDHNRRLTIPNPT 275

  Fly   250 -NDARF---ASLLQSTTLTTLVSGGALSTTATP----------VAALGNSF-----AHAVPGGQE 295
             :||.:   .::|:|:::.::|.|..||....|          .|.:....     |..||    
Human   276 GSDAGYYECEAVLRSSSVPSVVRGAYLSVLEPPQFVKEPERHITAEMEKVVDIPCQAKGVP---- 336

  Fly   296 RGNSSSLSW---------------------TLQIKYVNLEDAGWYEC---QLATEPKMSAKVQLF 336
               ..|::|                     .|||..:..:|.|.::|   ..|.|.:.|..:.:.
Human   337 ---PPSITWYKDAAVVEVEKLTRFRQRNDGGLQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVT 398

  Fly   337 VITPRTELIGDRQRFVKAGSRVELHCIVRGTLEAPK-YIFWYRGDQQVTAENEASGAQSGWYTQI 400
            .|.|.... |.....|..|..|.|.|...|   ||: .|.|.:|::.:     |||:     .|:
Human   399 SIAPNITR-GPLDSTVIDGMSVVLACETSG---APRPAITWQKGERIL-----ASGS-----VQL 449

  Fly   401 DRNIFGSTEHNRNTIGSLVIPLVRKIHSGNYTCEPENS-----AAASM----QLHVLSGEYSASA 456
            .|  |...|.     |||:|.......:|.|||...||     |:|.:    :..:.......|.
Human   450 PR--FTPLES-----GSLLISPTHISDAGTYTCLATNSRGVDEASADLVVWARTRITKPPQDQSV 507

  Fly   457 IKSTAA 462
            ||.|.|
Human   508 IKGTQA 513

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
dpr16NP_001287169.1 IG_like 205..337 CDD:214653 40/192 (21%)
Ig <298..338 CDD:299845 11/63 (17%)
IG_like 352..447 CDD:214653 30/104 (29%)
Ig 358..439 CDD:143165 26/86 (30%)
SDK2NP_001138424.1 Ig 27..109 CDD:299845
IG_like 40..109 CDD:214653
I-set 120..203 CDD:254352
Ig 132..210 CDD:299845
IG_like 222..304 CDD:214653 22/89 (25%)
IGc2 233..286 CDD:197706 13/60 (22%)
I-set 308..397 CDD:254352 16/95 (17%)
Ig 326..394 CDD:143165 14/74 (19%)
I-set 402..492 CDD:254352 32/110 (29%)
Ig 416..492 CDD:299845 29/95 (31%)
Ig 502..586 CDD:299845 5/12 (42%)
IG_like 502..586 CDD:214653 5/12 (42%)
FN3 590..681 CDD:238020
FN3 693..786 CDD:238020
FN3 794..890 CDD:238020
FN3 895..983 CDD:238020
FN3 993..1087 CDD:238020
FN3 1099..1194 CDD:238020
FN3 1201..1290 CDD:238020
FN3 1301..1394 CDD:238020
FN3 1400..1484 CDD:238020
FN3 1503..1616 CDD:238020
FN3 1626..1719 CDD:238020
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1707..1729
FN3 1724..1805 CDD:238020
FN3 1837..1916 CDD:238020
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2039..2067
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2098..2172
PDZ-binding. /evidence=ECO:0000250|UniProtKB:Q6V4S5 2166..2172
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3510
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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