DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpr16 and NCAM2

DIOPT Version :9

Sequence 1:	NP_001287169.1	Gene:	dpr16 / 40619	FlyBaseID:	FBgn0037295	Length:	488	Species:	Drosophila melanogaster
Sequence 2:	XP_011527877.1	Gene:	NCAM2 / 4685	HGNCID:	7657	Length:	874	Species:	Homo sapiens

Alignment Length:	348	Identity:	71/348 - (20%)
Similarity:	123/348 - (35%)	Gaps:	91/348 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   170 RLHAYDSEQKAQQLRREKELAKE---RELLPRRQLSLPPLNATVQAGQHAYLPCKLNQHSGKPLS 231
            |..|.|::.:.|:.....|:.::   ||::..::.         :.|:.|.:.|:::......:|
Human   117 RCQATDAKGQTQEATVVLEIYQKLTFREVVSPQEF---------KQGEDAEVVCRVSSSPAPAVS 172

  Fly   232 WVRLRDEHIIAVDHTTFINDARFASL----LQSTTLTTLVSG-----------GALS-------T 274
            |:...:|       .|.|:|.|||.|    ||...:.....|           |.:.       .
Human   173 WLYHNEE-------VTTISDNRFAMLANNNLQILNINKSDEGIYRCEGRVEARGEIDFRDIIVIV 230

  Fly   275 TATPVAAL-GNSFAHAVPGGQE-----RGNSS---SLSW--------------------TLQIKY 310
            ...|..:: ..||......|:|     |.:.|   ::||                    .|.::.
Human   231 NVPPAISMPQKSFNATAERGEEMTFSCRASGSPEPAISWFRNGKLIEENEKYILKGSNTELTVRN 295

  Fly   311 VNLEDAGWYECQL---ATEPKMSAKVQLFVITPRTELIGDRQRFVKAGSRVELHCIVRGTLEAPK 372
            :...|.|.|.|:.   |.|.:..|.:|:||   :..:|..:........:|.|.|...|  |...
Human   296 IINSDGGPYVCRATNKAGEDEKQAFLQVFV---QPHIIQLKNETTYENGQVTLVCDAEG--EPIP 355

  Fly   373 YIFWYRGDQQVTAENEASGAQSGWYTQIDRNIFGSTE-HNRNTIGSLVIPLVRKIHSGNYTCEPE 436
            .|.|.|.....|            :|:.|:::.|..| ..::...||.|..|:...||.|.||..
Human   356 EITWKRAVDGFT------------FTEGDKSLDGRIEVKGQHGSSSLHIKDVKLSDSGRYDCEAA 408

  Fly   437 NSAAASMQLHVLSGEYSASAIKS 459
            :......:...|..||:...|.:
Human   409 SRIGGHQKSMYLDIEYAPKFISN 431

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr16	NP_001287169.1	IG_like	205..337	CDD:214653	35/185 (19%)
		Ig	<298..338	CDD:299845	13/65 (20%)
		IG_like	352..447	CDD:214653	22/95 (23%)
		Ig	358..439	CDD:143165	22/81 (27%)
NCAM2	XP_011527877.1	Ig1_NCAM-2	46..137	CDD:143274	5/19 (26%)
		I-set	47..136	CDD:254352	4/18 (22%)
		I-set	142..218	CDD:254352	18/91 (20%)
		IGc2	153..214	CDD:197706	16/67 (24%)
		Ig	233..326	CDD:299845	20/95 (21%)
		I-set	240..323	CDD:254352	16/82 (20%)
		Ig5_NCAM-2	325..422	CDD:143278	25/113 (22%)
		IG_like	333..420	CDD:214653	22/100 (22%)
		IG_like	438..515	CDD:214653
		IGc2	439..507	CDD:197706
		FN3	521..613	CDD:238020
		fn3	619..703	CDD:278470
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900