DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpr16 and itgb4

DIOPT Version :9

Sequence 1:	NP_001287169.1	Gene:	dpr16 / 40619	FlyBaseID:	FBgn0037295	Length:	488	Species:	Drosophila melanogaster
Sequence 2:	XP_005166847.1	Gene:	itgb4 / 335269	ZFINID:	ZDB-GENE-030131-7209	Length:	1931	Species:	Danio rerio

Alignment Length:	217	Identity:	40/217 - (18%)
Similarity:	82/217 - (37%)	Gaps:	52/217 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   106 SWSDRPDTATLTKGFSIPSYLPPFPEFIPADLPHMLRNASSGAAPPADIGPSGSPMPSKPNEQSR 170
            ||::..:...:..|:.: .|:|...:..|.                   ||....|...|.::..
Zfish  1350 SWAEPAEANGIITGYEV-IYMPINEDKKPT-------------------GPPKKVMIDNPKKRML 1394

  Fly   171 L--HAYDSEQKAQQLRREKELA----KEREL----LPRRQLSLP-----PLNATVQAGQH--AYL 218
            |  :...|:....::|...::.    :|..:    .|.|.:|:|     |: ...:||:.  :||
Zfish  1395 LIENLQPSQTYCYKVRASNKVGWGPYREATINLASQPTRPMSIPIIPDIPI-VDAEAGEEYDSYL 1458

  Fly   219 PCKLNQHSGKPLSWVRLRDEHIIAVDHTTFINDARFAS-LLQSTTLTTLVSGGALSTTATPVAAL 282
            ... |:....|.|.:|         ...|.::|.:|.: ..:...|.....||:||..   :::.
Zfish  1459 MYS-NEVLRSPTSSLR---------PSVTDLSDDQFVNGKWEQNFLFPGGGGGSLSRN---ISSS 1510

  Fly   283 GNSFAHAVPGGQERGNSSSLSW 304
            ..:::|:.|......|||:.::
Zfish  1511 STTYSHSTPRTNVTNNSSTTTY 1532

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr16	NP_001287169.1	IG_like	205..337	CDD:214653	22/103 (21%)
		Ig	<298..338	CDD:299845	3/7 (43%)
		IG_like	352..447	CDD:214653
		Ig	358..439	CDD:143165
itgb4	XP_005166847.1	Integrin_beta	37..457	CDD:278776
		EGF_2	<468..490	CDD:285248
		EGF_2	545..573	CDD:285248
		Integrin_B_tail	625..709	CDD:285239
		Calx-beta	991..1064	CDD:295344
		FN3	1242..1326	CDD:238020
		FN3	1331..1420	CDD:238020	13/89 (15%)
		fn3	1640..1720	CDD:278470
		fn3	1751..1835	CDD:278470
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900