DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpr16 and dpr3

DIOPT Version :9

Sequence 1:	NP_001287169.1	Gene:	dpr16 / 40619	FlyBaseID:	FBgn0037295	Length:	488	Species:	Drosophila melanogaster
Sequence 2:	NP_001014459.2	Gene:	dpr3 / 3346208	FlyBaseID:	FBgn0053516	Length:	522	Species:	Drosophila melanogaster

Alignment Length:	542	Identity:	137/542 - (25%)
Similarity:	207/542 - (38%)	Gaps:	155/542 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 GILAGSG---------RSPG-TASILLAFLAAVSFRGMRAPLAATATPMENASLIASPATGTSTM 80
            |.|..||         |||| .|.:.:|..||    |....:||||.    |:..|:.....:|.
  Fly    46 GFLRRSGADDVDVIEPRSPGHAADVDVAAAAA----GATTSVAATAA----AAAAATTRAAATTR 102

  Fly    81 GSAGSPVLMLGDDQQQQE--------------YDTTVVDSWSDRPDTATLTKGFSIPSYLPPFPE 131
            .......|::...||||:              ..|...|...|.|..:|........|..||
  Fly   103 AVIIIMALVVSIMQQQQQSLLWPFCNGLAAAAASTGQPDDSGDGPTLSTFLSSSQSQSPSPP--- 164

  Fly   132 FIPADLPHMLRNASSGAAPPADIGPSGSPMPSKPNEQSRLH----------AYDSEQKAQ-QLRR 185
                       .||:.|:.|:..  |...:...|..::..|          ::.|:..|| ..:|
  Fly   165 -----------AASASASSPSSF--SSFAVAHGPQTEATNHTFKSLAFLDASFGSDLFAQTDAKR 216

  Fly   186 EKELAKERELLPR-RQLSLP------PLNATVQAGQ-HAYLPCKLNQHSGKPLSWVRLRDEHIIA 242
            |:..|.:.|.... ...|||      |.|.|.:.|. .|.:.|:::....|.:||:|.||.||:.
  Fly   217 ERSGAADEESQDADTSQSLPIFDFGMPRNITGRTGHTEAIIKCRVDSLHDKSVSWIRKRDLHILT 281

  Fly   243 VDHTTFINDARFASLLQSTTLTTLVSGGALSTTATPVAALGNSFAHAVPGGQERGNSSSLSWTLQ 307
            |...|:.:|.||                                       |...:..|..|||.
  Fly   282 VGTATYTSDKRF---------------------------------------QVTESKDSREWTLH 307

  Fly   308 IKYVNLEDAGWYECQLATEPKMSAKVQLFV--ITPRTELI--GDRQRFVKAGSRVELHCIVRGTL 368
            :|....:|:|.||||:.||||||...||.:  |:|..:.:  |......||||.:.|:|:|
  Fly   308 VKAPLAKDSGIYECQVNTEPKMSMAFQLNIIEISPDAKAVISGPPDLHFKAGSAIILNCLV---- 368

  Fly   369 EAPKY-----IFWYRGDQQVTAENEASG-----AQSGWYTQ--------------IDRNI----- 404
            :.|..     |:||||:..:|..:...|     |..|.:.|              :|..:
  Fly   369 QQPSVKDIGPIYWYRGEHMITPFDADDGQPEIPAGRGEHPQGIPEDTSPNDIMSEVDLQMEFATR 433

  Fly   405 ------FGSTEHNRNTIGSLVIPLVRKIHSGNYTCEPENSAAASMQLHVLSGEYSASAIKSTAAR 463
                  .|.|..:|     |.|...:...:|||||:|..:::||:.:||::.| :.:|::.:.|.
  Fly   434 IAMESQLGDTLKSR-----LRISNAQTTDTGNYTCQPTTASSASVLVHVINDE-NPAAMQKSGAC 492

  Fly   464 PHRLGHGYTSLHQWLIFLLVAL 485
            |..||.....||..|:..|:.|
  Fly   493 PCALGPLQLLLHLLLLPELLLL 514

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr16	NP_001287169.1	IG_like	205..337	CDD:214653	39/132 (30%)
		Ig	<298..338	CDD:299845	19/41 (46%)
		IG_like	352..447	CDD:214653	32/129 (25%)
		Ig	358..439	CDD:143165	26/115 (23%)
dpr3	NP_001014459.2	Ig	243..330	CDD:299845	35/125 (28%)
		IG_like	243..329	CDD:214653	34/124 (27%)
		Ig	350..464	CDD:299845	29/122 (24%)
		IG_like	<441..477	CDD:214653	13/40 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45444690
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	82	1.000	Inparanoid score	I5030
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1457433at2759
OrthoFinder	1	1.000	-	-		FOG0000207
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23279
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	7	6.900