DRSC/TRiP Functional Genomics Resources

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Protein Alignment dpr16 and CADM4

DIOPT Version :9

Sequence 1:NP_001287169.1 Gene:dpr16 / 40619 FlyBaseID:FBgn0037295 Length:488 Species:Drosophila melanogaster
Sequence 2:NP_660339.1 Gene:CADM4 / 199731 HGNCID:30825 Length:388 Species:Homo sapiens


Alignment Length:349 Identity:76/349 - (21%)
Similarity:120/349 - (34%) Gaps:109/349 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   207 NATVQAGQHAYLPCKLNQHSGKPLSWVRLRDEHIIAVDH----TTFIN----------------- 250
            |.||..|..|.:.|:|:|:.|.           |:.:.:    |.|.|                 
Human    31 NVTVAEGGVAEITCRLHQYDGS-----------IVVIQNPARQTLFFNGTRALKDERFQLEEFSP 84

  Fly   251 --------DAR-------FASLL------QSTTLTTLVS--------------GG-----ALSTT 275
                    |||       |..|.      |..|||.||:              ||     .|...
Human    85 RRVRIRLSDARLEDEGGYFCQLYTEDTHHQIATLTVLVAPENPVVEVREQAVEGGEVELSCLVPR 149

  Fly   276 ATPVAAL----GNSFAHAVPGGQERGNSSSLSWTLQIKYVNLEDAGWYECQLATE--PKMSAKVQ 334
            :.|.|.|    .......|...||.|...|::.|::.:....:|.|...|:...:  |...:|..
Human   150 SRPAATLRWYRDRKELKGVSSSQENGKVWSVASTVRFRVDRKDDGGIIICEAQNQALPSGHSKQT 214

  Fly   335 LFVITPR---TELIGDRQRFVKAGSRVELHCIVRGTLEAPKYIFWYRGDQQVTAENEASGAQSGW 396
            .:|:..:   |..|...|..|:.|..:.|.|.|.|. ..|..|.|.||::.:....||.|.    
Human   215 QYVLDV
QYSPTARIHASQAVVREGDTLVLTCAVTGN-PRPNQIRWNRGNESLPERAEAVGE---- 274

  Fly   397 YTQIDRNIFGSTEHNRNTIGSLVIPLVRKIHSGNYTCEPENSAAASMQLHVLSGEYSASAIKSTA 461
                                :|.:|.:....:|.||||..|....:..|:||......:.:::..
Human   275 --------------------TLTLPGLVSADNGTYTCEASNKHGHARALYVLVVYDPGAVVEAQT 319

  Fly   462 ARPHRLGHGYTSLHQWLIFLLVAL 485
            :.|:.:..|..:|   |:||::.:
Human   320 SVPYAIVGGILAL---LVFLIICV 340

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
dpr16NP_001287169.1 IG_like 205..337 CDD:214653 41/196 (21%)
Ig <298..338 CDD:299845 7/41 (17%)
IG_like 352..447 CDD:214653 23/94 (24%)
Ig 358..439 CDD:143165 20/80 (25%)
CADM4NP_660339.1 Ig 29..120 CDD:416386 21/99 (21%)
FR1 29..45 CDD:409353 5/13 (38%)
Ig strand A' 30..36 CDD:409353 3/4 (75%)
Ig strand B 38..46 CDD:409353 2/7 (29%)
CDR1 46..51 CDD:409353 2/4 (50%)
FR2 52..59 CDD:409353 1/17 (6%)
Ig strand C 52..58 CDD:409353 1/16 (6%)
CDR2 60..71 CDD:409353 3/10 (30%)
Ig strand C' 62..66 CDD:409353 1/3 (33%)
Ig strand C' 68..71 CDD:409353 0/2 (0%)
FR3 72..107 CDD:409353 4/34 (12%)
Ig strand D 76..83 CDD:409353 0/6 (0%)
Ig strand E 86..92 CDD:409353 0/5 (0%)
Ig strand F 99..107 CDD:409353 1/7 (14%)
CDR3 108..111 CDD:409353 0/2 (0%)
Ig strand G 111..120 CDD:409353 3/8 (38%)
FR4 113..120 CDD:409353 3/6 (50%)
IgI_2_Necl-4 121..220 CDD:409468 20/98 (20%)
Ig strand B 141..145 CDD:409468 0/3 (0%)
Ig strand C 155..159 CDD:409468 1/3 (33%)
Ig strand E 182..186 CDD:409468 1/3 (33%)
Ig strand F 196..201 CDD:409468 1/4 (25%)
Ig strand G 213..216 CDD:409468 0/2 (0%)
Ig_3 224..295 CDD:404760 24/95 (25%)
Ig strand A' 231..235 CDD:409353 1/3 (33%)
Ig strand B 241..248 CDD:409353 2/6 (33%)
Ig strand C 255..260 CDD:409353 2/4 (50%)
Ig strand C' 262..264 CDD:409353 0/1 (0%)
Ig strand E 274..280 CDD:409353 1/29 (3%)
Ig strand F 287..294 CDD:409353 5/6 (83%)
Ig strand G 300..308 CDD:409353 3/7 (43%)
4.1m 344..362 CDD:128590
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 79 1.000 Inparanoid score I5236
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.960

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