DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14662 and AgaP_AGAP006180

DIOPT Version :9

Sequence 1:	NP_649510.2	Gene:	CG14662 / 40614	FlyBaseID:	FBgn0037291	Length:	550	Species:	Drosophila melanogaster
Sequence 2:	XP_556882.3	Gene:	AgaP_AGAP006180 / 3290121	VectorBaseID:	AGAP006180	Length:	713	Species:	Anopheles gambiae

Alignment Length:	689	Identity:	124/689 - (17%)
Similarity:	194/689 - (28%)	Gaps:	317/689 - (46%)

- Green bases have known domain annotations that are detailed below.

  Fly   117 ITSLQLINVQLENLTESALEGLQKLQNFTLVN-ENNHFRPFGFLSAVAESLVSAEIHQSLAAAIS 180
            :|.|.|.::.:::|......|||.|:...|:| ......|: .||.:..||....|..||
Mosquito     4 MTVLTLQSLMIDHLPTGIFLGLQSLKELNLLNLPLRQIDPY-VLSPMKYSLTRLTIESSL----- 62

  Fly   181 YSVCDFLGSRN------FPQLKYLDLSGTHLDKSLIKESFDNLPALEQLLLRNCGLGNIE---WE 236
                |.:|.:|      .|:|:.|.|.....|.:|.:.:|.|||:|..|.||:..:.::|   :.
Mosquito    63 ----DGIGPKNLTGSATLPRLEILSLEYNSFDDTLRQGTFANLPSLTSLYLRSSHITSLEVGVFH 123

  Fly   237 IVRPRLKLLH--------------------------------------YL--------------- 248
            .:...:|.:|                                      ||
Mosquito   124 DICSSVKQIHLIGNKLTSVSPGTFDCLRGTEAKIYLKDNAWYCDCSLQYLQELLVNSNLVLDQPV 188

  Fly   249 -----DLGGA------------------------------------------------------- 253
                 :|.|.
Mosquito   189 CDGPVELRGVLVRNAMLCPVSTSSIIPSGELTTETTTELFTTVAPNDGSSTSTSVSTTALQTTTE 253

  Fly   254 -------------------------QKTGNYEHQLDVSAF----------------------SPE 271
                                     |.||:.....|...:                      :||
Mosquito   254 EDTTAIATSSTDEETSSSYETTTEDQSTGDDSTTTDTIEYTTSSSSITTSVSDTTTELSTETTPE 318

  Fly   272 TTTNAE-----EIST-----ILAKRAMAPEVVGTTTLGPTTSIEISPPSTQS-----TTTPKEES 321
            .||:.|     |.:|     .....|..||...||....||:.|..|.:|:|     ||||:..:
Mosquito   319 LTTSTELTTSTESTTSTSTFTTTTEATTPETTSTTNAYETTTPETDPTTTESSPVTTTTTPEVTT 383

  Fly   322 TSMTE----TTILTT-----PSP---------KCE---EELCQDLECSRITTDTVASADLGK--- 362
            |..|.    ||..||     |.|         :||   ..|..::...:.....:.|.|.|.
Mosquito   384 TDSTSPEHTTTDATTSTTYHPVPTVLPNFVQLQCESTANPLSVEISSEKAQQRLIRSTDFGTISL 448

  Fly   363 -----------SSCQDGLLVEICEST---------------------------CTTPT------- 382
                       |..|:|::..:.:.|                           |.|.:
Mosquito   449 NVATRTKLFTISEAQEGVVELLFDKTTYGAVLWFHDTSTLASVFSTNIESSAHCQTLSSQQVRIV 513

  Fly   383 --------FFCVI-LGENFTSASNCCSHHTMRCVVSAQVSWF-EDHSGLVIGLGVGLLFIGSFLG 437
                    .||.. |.|...|..||..:..:  .|..|.:|. ||...::|.:.:..:.:....|
Mosquito   514 NLVPDKNYLFCAFSLHEVMVSPFNCLPYRLL--PVYGQRAWLVEDQKIMMISIIISSILVALLTG 576

  Fly   438 MLIVFGTLRLNPSWLRGNKRRESNTIGLIQGRFEKDPYEQVGGPIATIDNNEYVTAYHRYLEQAN 502
            :|:.:...: :.|..:.|.:|..:...:..||                   .||:|.
Mosquito   577 VLVTYCFFK-SMSLYQPNIQRSVSDTSIESGR-------------------SYVSAV-------- 613

  Fly   503 HRPTESNKYI--------RPPRDRAPSVPPSSDYPLPLP 533
             .||...:||        ||..:..|:.||    |.|||
Mosquito   614 -VPTTQFQYISWKMENRSRPSLEFYPNEPP----PPPLP 647

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14662	NP_649510.2	leucine-rich repeat	91..116	CDD:275380
		leucine-rich repeat	117..140	CDD:275380	6/22 (27%)
		leucine-rich repeat	162..194	CDD:275380	8/37 (22%)
		LRR_8	<190..230	CDD:290566	15/45 (33%)
		leucine-rich repeat	195..219	CDD:275380	8/23 (35%)
		leucine-rich repeat	220..244	CDD:275380	5/26 (19%)
AgaP_AGAP006180	XP_556882.3	leucine-rich repeat	5..27	CDD:275380	6/21 (29%)
		leucine-rich repeat	28..55	CDD:275380	8/27 (30%)
		leucine-rich repeat	56..78	CDD:275380	6/30 (20%)
		LRR_8	77..139	CDD:290566	17/61 (28%)
		leucine-rich repeat	79..103	CDD:275380	8/23 (35%)
		leucine-rich repeat	104..128	CDD:275380	5/23 (22%)
		leucine-rich repeat	129..150	CDD:275380	2/20 (10%)
		LRRCT	162..201	CDD:214507	4/38 (11%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	84	1.000	Inparanoid score	I7439
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.050