DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cdep and FRMD7

DIOPT Version :9

Sequence 1:	NP_001097685.2	Gene:	Cdep / 40608	FlyBaseID:	FBgn0265082	Length:	4273	Species:	Drosophila melanogaster
Sequence 2:	NP_919253.1	Gene:	FRMD7 / 90167	HGNCID:	8079	Length:	714	Species:	Homo sapiens

Alignment Length:	729	Identity:	229/729 - (31%)
Similarity:	334/729 - (45%)	Gaps:	154/729 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 LTVRIQMLDDSITMFQVQAKALGRVLFEQVCRQLNLLEADYFGLEYQEVSTHT--KYWLDLEKPM 131
            |.:::|.||||..:|.|..|:.|:.||...|..|||.|.:|||||:   .:|:  ..||:|.||:
Human     2 LHLKVQFLDDSQKIFVVDQKSSGKALFNLSCSHLNLAEKEYFGLEF---CSHSGNNVWLELLKPI 63

  Fly   132 NRQVGLSLIDP---VLRFCIKFYTPDPAQLEEEYTRYLFCLQIKRDLATGSLQCNDNTAALMASY 193
            .:||.    :|   |.:|.:||:..||..|.||.|||||.||||:|||.|.|.|:||..|||.|:
Human    64 TKQVK----NPKEIVFKFMVKFFPVDPGHLREELTRYLFTLQIKKDLALGRLPCSDNCTALMVSH 124

  Fly   194 IVQASCGDFVPEDYPDHTYLSSYRFVPNQDATMQRKIMENHKKHVGQSPAEADLNLLETARRCEL 258
            |:|:..|||..|  .|..:|:..|::||||. ::.|||..|:||:|:||||:|:.||:.||:.::
Human   125 ILQSELGDFHEE--TDRKHLAQTRYLPNQDC-LEGKIMHFHQKHIGRSPAESDILLLDIARKLDM 186

  Fly   259 YGMKMHPAKDVEGVPLNLAVAHMGITVFQNITRINTFSWAKIRKISFKRKRFLVKLHPEGYGYYK 323
            ||::.|||.|.||:.::|||||||:.|.:..|:||||:||||||:|||||.||:|||.......|
Human   187 YGIRPHPASDGEGMQIHLAVAHMGVLVLRGNTKINTFNWAKIRKLSFKRKHFLIKLHANILVLCK 251

  Fly   324 DTVEFFFEGRNECKNFWKKCVENHGFFRCTAVQNTPRRKTRVL--SRGSSFRYSGKTQKQIIEFV 386
            ||:||....|:.||.|||.|||.|.|||   :...|:.|.:.|  |:||||||||:||:|::|:.
Human   252 DTLEFTMASRDACKAFWKTCVEYHAFFR---LSEEPKSKPKTLLCSKGSSFRYSGRTQRQLLEYG 313

  Fly   387 RENYVKRQNFQRSQSFRQGPLNASSRSQSHTYVNSSISANPLLPIDTAAWDYRNQCSDSMTPSLT 451
            |:..:|...|:|    :..|      ||.|                      ..||..|  |.|.
Human   314 RKGRLKSLPFER----KHYP------SQYH----------------------ERQCRSS--PDLL 344

  Fly   452 KKAADTLDRRRDNPIGHMRSQVTAAQVEIYQTKN-YAADSPTSQEEAECSAA----GAERQHHSA 511
            ...:..::..|           .|.....||..| ..|..|..:.....||.    ..|.:|...
Human   345 SDVSKQVEDLR-----------LAYGGGYYQNVNGVHASEPVLESRRRNSALEVTFATELEHSKP 398

  Fly   512 VAMDKLNSNRSLSPQGPQSWTSPSHSSHHQQRGPDPARVHPGDHNTGLS-----------HLSHL 565
            .|...|......|...|..:..|..:: .....|||..:.  ...:.||           |:| :
Human   399 EADPTLLHQSQSSSSFPFIYMDPVFNT-EPNPNPDPRDIF--SERSSLSSFQTSCKFSGNHMS-I 459

  Fly   566 YSSST-----PRRVSVGSQAFVPASPQLISINTP---------------------SSSTNHNTMH 604
            ||..|     .::::.....::|.:.|.:.|..|                     ..::.|:.:.
Human   460 YSGLTSKVRPAKQLTYTDVPYIPCTGQQVGIMPPQVFFYVDKPPQVPRWSPIRAEERTSPHSYVE 524

  Fly   605 STSTV--------VRSVDLNSSMELEEEAEDPGTADTEEEEGEPVGEEEEEELVEEEVDSDLTAS 661
            .|:..        :|.......:::.:||    .|.|.......||.|||:..:|:....::...
Human   525 PTAMKPAERSPRNIRMKSFQQDLQVLQEA----IARTSGRSNINVGLEEEDPNLEDAFVCNIQEQ 585

  Fly   662 TINR------------------ETMGAASAAAASASALGSGLASAHRPQL-------------RS 695
            |..|                  ..:|...|.:..|.......|....|.:             .|
Human   586 TPKRSQSQSDMKTIRFPFGSEFRPLGPCPALSHKADLFTDMFAEQELPAVLMDQSTAERYVASES 650

  Fly   696 QESQSLTATPVHYS 709
            .:|:|....|.:|:
Human   651 SDSESEILKPDYYA 664

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cdep	NP_001097685.2	B41	70..264	CDD:214604	91/198 (46%)
		FERM_N	73..134	CDD:286467	27/62 (44%)
		FERM_B-lobe	163..256	CDD:271216	50/92 (54%)
		FERM_C_FARP1-like	251..372	CDD:270014	63/122 (52%)
		FA	364..406	CDD:285894	18/43 (42%)
FRMD7	NP_919253.1	B41	3..192	CDD:214604	91/198 (46%)
		FERM_N	6..69	CDD:286467	29/69 (42%)
		FERM_M	88..192	CDD:278785	55/106 (52%)
		FERM_C_FARP1-like	179..299	CDD:270014	63/122 (52%)
		FA	294..327	CDD:285894	17/36 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	125	1.000	Domainoid score	I5483
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm41275
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45858
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	4.010