DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cdep and frmd7

DIOPT Version :9

Sequence 1:	NP_001097685.2	Gene:	Cdep / 40608	FlyBaseID:	FBgn0265082	Length:	4273	Species:	Drosophila melanogaster
Sequence 2:	XP_017952463.2	Gene:	frmd7 / 779686	XenbaseID:	XB-GENE-6041331	Length:	710	Species:	Xenopus tropicalis

Alignment Length:	789	Identity:	239/789 - (30%)
Similarity:	354/789 - (44%)	Gaps:	156/789 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 LTVRIQMLDDSITMFQVQAKALGRVLFEQVCRQLNLLEADYFGLEYQEVSTHT--KYWLDLEKPM 131
            |.:::|.||||...|.|..||.|:.||...|..|||.|.:|||||::   .|.  :.||.|.||:
Frog     2 LHLKVQFLDDSQKTFVVDQKAPGKELFNMSCSHLNLTEKEYFGLEFR---NHAGCQMWLGLLKPI 63

  Fly   132 NRQVGLSLIDPVLRFCIKFYTPDPAQLEEEYTRYLFCLQIKRDLATGSLQCNDNTAALMASYIVQ 196
            .:||.... :.:.:|.:||:..||..|:.|.|||||.||||::||:|.|.||||:|||||||::|
Frog    64 TKQVKHPK-ETIFKFMVKFFLVDPGLLKGELTRYLFALQIKKNLASGKLPCNDNSAALMASYVLQ 127

  Fly   197 ASCGDFVPEDYPDHTYLSSYRFVPNQDATMQRKIMENHKKHVGQSPAEADLNLLETARRCELYGM 261
            :..|||  |:.....:|...:::|||: .:..||::.:::|||:||||:|:.||:.||:.:.||:
Frog   128 SELGDF--EEDTARKHLEQNQYLPNQE-YLDNKILKYYQRHVGKSPAESDMQLLDIARKLDTYGI 189

  Fly   262 KMHPAKDVEGVPLNLAVAHMGITVFQNITRINTFSWAKIRKISFKRKRFLVKLHPEGYGYYKDTV 326
            :.|.|.|.||:.:||||||||:.|.:..|:||||:||.|||:|||||.||:||||......|||:
Frog   190 RPHAASDGEGMQINLAVAHMGVLVLRGNTKINTFNWANIRKLSFKRKHFLIKLHPHIDTLCKDTL 254

  Fly   327 EFFFEGRNECKNFWKKCVENHGFFRCTAVQNTPRRKTR--VLSRGSSFRYSGKTQKQIIEFVREN 389
            .|..|.|:.||.|||.|||.|.|||   :...|:||.:  :.|:||:|||||:|||||.:...:.
Frog   255 VFTMESRDACKAFWKSCVEYHAFFR---LSEEPKRKPKPFLCSKGSNFRYSGRTQKQIFDSWTKG 316

  Fly   390 YVKRQNFQRSQSFRQGPLNASSRSQSHTYVNSSISANPLLPIDTAAWDYRNQCSDSMTPS-LTKK 453
            ..|...|:|                .|...|.                :..||..|  |. ||:.
Frog   317 NSKNLPFER----------------RHLLANL----------------HERQCRSS--PDLLTEV 347

  Fly   454 AADTLD----------RRRDNPIG-----HMRSQVTAAQVEIYQTKNYAADSPTSQEEAE----- 498
            |....|          .|..|.:|     |...:.:|.::      .::||...|:...|
Frog   348 AKQPNDFKLIYTSRPCSRSANSVGWDPPMHKNRRKSATEI------IFSADLERSKPNEEPTILQ 406

  Fly   499 -----CSAAG---------AERQHHSAVAMDKLNSNRSLS------PQGPQSWTSPSHSSHHQQR 543
                 ||..|         |.|..::...:.....::..|      .:|.....:|..|:.:..|
Frog   407 LSKSSCSFPGCSYLDIKDNAPRTGYNKRPLSYYEDSKYFSGNFKSMSEGCMRDAAPLPSAIYTDR 471

  Fly   544 GPDPARVHP--GDHNTGLSHLSHLYSSSTPRRVSVGSQAFVPASPQLISINTPSSSTNHNTMHST 606
            .|.|...|.  .|....|.:..||  ||.|::.|...:..|..:      |.||:....:...|.
Frog   472 VPLPHSSHQLNSDSVDYLCYSDHL--SSIPQQTSAIVEEIVRLT------NKPSTFLEKSANRSP 528

  Fly   607 ST---------VVRSVDLNSSMELEEEAEDPGTADTEEEEGEPVGEEEEEELVEEEVDSDLTAST 662
            |.         |.......||:.:..:.|...|.....::..|     :..|...::.|......
Frog   529 SARRIKEYHQPVYPRTSCRSSISMVPKRESQVTHVEYTQDPYP-----KRSLSHSDMKSSWFPCG 588

  Fly   663 INRETMGAASAAAASASALGSGLASAH---------------RPQLRSQESQSLTATPVHYSSTN 712
            .....:|.....:.::|.....|...|               .|.|...|::.:..|...|
Frog   589 SEFRPLGPCPILSKTSSISTRPLVPQHLPIPHQLPPPPPPPPAPPLPLTETKKVPRTTERY---- 649

  Fly   713 YSMSKQCMLNNANANSTETETDNIIYTDINDMGHYKYPDFHSSAHQEHKISN-SEHLNLNERNDI 776
                   :.:...::.:|||..|..|        |.....|.|.....::|: |..|:..|.|.|
Frog   650 -------VYSGTESSDSETEIINPYY--------YALFGKHRSPLTRIRLSSGSLQLDEEENNAI 699

  Fly   777 --YATVNRK 783
              ::..|||
Frog   700 NWHSRENRK 708

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cdep	NP_001097685.2	B41	70..264	CDD:214604	86/195 (44%)
		FERM_N	73..134	CDD:286467	28/62 (45%)
		FERM_B-lobe	163..256	CDD:271216	47/92 (51%)
		FERM_C_FARP1-like	251..372	CDD:270014	63/122 (52%)
		FA	364..406	CDD:285894	16/43 (37%)
frmd7	XP_017952463.2	FERM_F1_FRMD7	1..86	CDD:340708	34/87 (39%)
		FERM_B-lobe	94..184	CDD:271216	47/92 (51%)
		FERM_C_FARP1-like	179..299	CDD:270014	63/122 (52%)
		FA	294..327	CDD:400882	16/48 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	120	1.000	Domainoid score	I5678
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm48480
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.910