DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cdep and frmd7

DIOPT Version :9

Sequence 1:	NP_001097685.2	Gene:	Cdep / 40608	FlyBaseID:	FBgn0265082	Length:	4273	Species:	Drosophila melanogaster
Sequence 2:	XP_005173955.2	Gene:	frmd7 / 751637	ZFINID:	ZDB-GENE-060825-67	Length:	722	Species:	Danio rerio

Alignment Length:	747	Identity:	236/747 - (31%)
Similarity:	334/747 - (44%)	Gaps:	182/747 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 GLPGGRMTHSLSTPSGVDGTPSTPRHRGGKK-----------------------------LTVRI 73
            |...|.:...:...:|.|.| .|..|.|.:|                             .::|:
Zfish    10 GRSDGELQFDIPHLTGEDKT-GTNSHHGIRKTLCVHEGDMNMSDRKKHVKTSENTRKDSLFSLRV 73

  Fly    74 QMLDDSITMFQVQAKALGRVLFEQVCRQLNLLEADYFGLEYQEVSTH--TKYWLDLEKPMNRQVG 136
            ..||||..:||::.:.||:..|..||..|.|:|.:|||||::.   |  :..||:|.||:.:|:
Zfish    74 IFLDDSEHVFQMEQRVLGKDFFNSVCGHLKLVEKEYFGLEFRH---HCGSYVWLELLKPLAKQI- 134

  Fly   137 LSLIDPVLRFCIKFYTPDPAQLEEEYTRYLFCLQIKRDLATGSLQCNDNTAALMASYIVQASCGD 201
            ....|.:.||.:||:.|||.:|:.|.|||||.||||:||:.|||.|:||:|||:.||::||..||
Zfish   135 KRRNDLIFRFIVKFFPPDPGELQREVTRYLFALQIKQDLSNGSLTCSDNSAALLVSYLLQAEIGD 199

  Fly   202 FVPEDYPDHTYLSSYRFVPNQDATMQRKIMENHKKHVGQSPAEADLNLLETARRCELYGMKMHPA 266
            |:.|  .|..:|.:.|::|||| .:.:|||..||:|.||||||||..|||.:|:.::||::.|.|
Zfish   200 FIEE--LDKQHLENKRYIPNQD-VLHKKIMRFHKRHRGQSPAEADHQLLEVSRKLDMYGIRPHAA 261

  Fly   267 KDVEGVPLNLAVAHMGITVFQNITRINTFSWAKIRKISFKRKRFLVKLHPEGYGYYKDTVEFFFE 331
            .|.|.:.:||||.|.|:.|||..|:|||||||.:||:|||||.||:|||.......||||||...
Zfish   262 TDGENMRINLAVTHCGVLVFQGNTKINTFSWANVRKLSFKRKHFLIKLHTTIVASCKDTVEFTMA 326

  Fly   332 GRNECKNFWKKCVENHGFFRCTAVQNTPRRKTRVL--SRGSSFRYSGKTQKQIIEFVRENYVK-R 393
            .|:.||.|||.|||.|.|||   :...|:.|.:.|  ||||.|||||:||||:::|.:::..| .
Zfish   327 NRDVCKAFWKMCVEYHTFFR---LSQEPKSKQKSLLYSRGSCFRYSGRTQKQLLDFTKKSEEKIN 388

  Fly   394 QNFQRSQSFRQGPLNASSRSQSHTYVNSSISANPLLPIDTAAWDYRNQCSDSMTPSLTKK---AA 455
            ..|.|...             ...|......::|.|..|.:...|...|  ...|...|:   |.
Zfish   389 LPFMRKYC-------------KDYYDTRQCRSSPDLLTDVSKQAYEQSC--GFPPPSGKRCQSAV 438

  Fly   456 DTLDRR--RDNP--IGHMRSQVTAAQVEIYQTKNYAADSPTSQEEAECSAAGAERQH-------- 508
            :.|:..  :|.|  :.|..|:.|.|..::.:...:       ...|.|....|. ||
Zfish   439 EVLNTSEFQDPPSSLQHFYSEATQASPDVQRVHRH-------DRRAGCRCCCAP-QHGRLNKQNL 495

  Fly   509 --------------HSAVAMDKLN----------------------------SNRSLSPQGPQSW 531
                          |..:.:..:|                            :.||.|..| .|:
Zfish   496 VFLYPNHPHPGLHLHPFLPVCPINAAFALGHPCAPVLLPCHSFSPPACFPDDATRSYSFSG-SSY 559

  Fly   532 TSPSHSSHHQQRGPDPARVHPG--------DHNTGLSHLSH--LYSSSTPRRVSVGS-------- 578
            .|||..::.:...|......||        .|...|.|.|.  .|.:..|||....|
Zfish   560 VSPSILNYQRYCWPTAFGPMPGFYVAGSFEGHREDLGHFSDDCSYQTGLPRRSYSQSDLKTLCHP 624

  Fly   579 QAFVPAS--PQL-------------ISINTPSSSTNHNTMHSTS--------------TVVRSVD 614
            ..|.|..  |.|             :..:.|...:.....||.|              .:|||..
Zfish   625 DEFRPLGHYPHLSRRQGLVRPTYLPLRSSLPPEGSRSELSHSDSDSDATCSFYCPGLGRLVRSAP 689

  Fly   615 L------NSSMELEEEA---EDPGTADTEEEE 637
            |      :.|::|:||.   ||..||..::.:
Zfish   690 LARMRISSGSLQLDEEGDSNEDAATAKRDKRK 721

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cdep	NP_001097685.2	B41	70..264	CDD:214604	92/195 (47%)
		FERM_N	73..134	CDD:286467	25/62 (40%)
		FERM_B-lobe	163..256	CDD:271216	53/92 (58%)
		FERM_C_FARP1-like	251..372	CDD:270014	63/122 (52%)
		FA	364..406	CDD:285894	18/44 (41%)
frmd7	XP_005173955.2	B41	71..259	CDD:214604	92/194 (47%)
		FERM_C_FARP1-like	246..366	CDD:270014	63/122 (52%)
		FA	359..394	CDD:312314	16/34 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	123	1.000	Domainoid score	I5523
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910