Protein Alignment Cdep and epb41l3

DIOPT Version :10

• Sequence 1: NP_001097685.2
• Gene: Cdep / 40608
• FlyBaseID: FBgn0265082
• Length: 4273
• Species: Drosophila melanogaster
• Sequence 2: XP_017950527.2
• Gene: epb41l3 / 613048
• XenbaseID: XB-GENE-1006073
• Length: 1407
• Species: Xenopus tropicalis
• Alignment Length: 1630
• Identity: 363/1630 - (22%)
• Similarity: 574/1630 - (35%)
• Gaps: 509/1630 - (31%)

  Fly    48 LSTPSGVDGTPSTP--RHRGGKKLTVRIQMLDDSITMFQVQAKALGRVLFEQVCRQLNLLEADYF 110
            :|..||......:|  ..|..|.:..::.:||.|....:|:.::.|::|||:||..|||||.|||
 Frog    87 VSQKSGSSKLSKSPLKSARRPKNMQAKVMLLDGSEYSCEVEKRSKGQILFEKVCEHLNLLEKDYF 151

  Fly   111 GLEYQEVSTHTKYWLDLEKPMNRQVGLSLIDPVLRFCIKFYTPDPAQLEEEYTRYLFCLQIKRDL 175
            ||.|:: |.:.|.|||..|.:.:|.......  ..|.:|||.|||:||.|:.|||..|||::.|:
 Frog   152 GLVYRD-SENQKNWLDPAKEIKKQTRNGAWH--FSFNVKFYPPDPSQLSEDITRYYLCLQLRDDI 213

  Fly   176 ATGSLQCNDNTAALMASYIVQASCGDFVPEDYPDHTYLSSYRFVPNQDATMQRKIMENHKKHVGQ 240
            ..|.|.|:..|.||:.||.||:..||:.||:| ...|::.:||.|||...::.|::|.||.:.|.
 Frog   214 VCGRLPCSFVTLALLGSYSVQSELGDYDPEEY-GSDYVTEFRFAPNQTKELEDKVVELHKSYRGM 277

  Fly   241 SPAEADLNLLETARRCELYGMKMHPAKDVEGVPLNLAVAHMGITVFQNITRINTFSWAKIRKISF 305
            :||||:::.||.|::..:||:.:|.|||.|||.:.|.|...|:.::::..|||.|:|.|:.|||:
 Frog   278 TPAEAEMHFLENAKKLSMYGVDLHHAKDSEGVEIMLGVCASGLLIYRDRLRINRFAWPKVLKISY 342

  Fly   306 KRKRFLVKLHPEGYGYYKDTVEFFFEGRNECKNFWKKCVENHGFFRCTAVQNTPRRKTRVLSRGS 370
            ||..|.:|:.|..:..::.|:.|........|..||.|||:|.|||....:..|:   :.|:.||
 Frog   343 KRNNFYIKIRPGEFEQFESTIGFKLPNHRAAKRLWKVCVEHHTFFRLLMPEAPPK---KFLTLGS 404

  Fly   371 SFRYSGKTQKQIIEFVRENYVKRQN---------FQRSQSFR---QGPLNASSRSQSH-TYVNSS 422
            .|||||:||.|         .:|.:         |:||.|.|   ...|:.:|.:::| .|:..|
 Frog   405 KFRYSGRTQAQ---------TRRASALIDRPAPYFERSSSKRYTMSRSLDGASVNENHDLYMKDS 460

  Fly   423 ISANPL--LPIDTAAWDYRNQCSDSMTPSLTKKAADTLDRRRDNPIGHMRSQVTAAQVEIYQTKN 485
            :||..:  .|..||....:.....::||.  |||.:..|...:.          ..:|||..|..
 Frog   461 VSATEVGTGPYITAKGISQTNLITTVTPE--KKAEEERDEEEEK----------KKKVEIITTVT 513

  Fly   486 YAADSPTSQEEAECSAAGAERQHHSAVAMDKLNSNRSLSPQGPQSWTSPSHSSHHQQRGPDPARV 550
                  |.:.:.:.|....:..|               ||..|.|  |||.||...:|
 Frog   514 ------TIRHDTKPSCFDTDSFH---------------SPSHPHS--SPSASSTKLRR------- 548

  Fly   551 HPGDHNTGLSHLSHLYSSSTPRRVSVGSQAFVPASPQLISINTPSSSTNHNTMHSTSTVVRSVDL 615
                            ......|.:||.:.                               |.|:
 Frog   549 ----------------RCKENARKAVGREL-------------------------------SKDV 566

  Fly   616 NS-SMELEEEAEDPGTADTEEEEGEPVGEEEEEELVEEEVDSDLTASTINRETMGAASAAAASAS 679
            |. |.|.|.:::..||...||:|
 Frog   567 NEMSHEPERDSDCKGTLYPEEDE------------------------------------------ 589

  Fly   680 ALGSGLASAHRPQLRSQESQSLTATPVHYSSTNYSMSKQCMLNNANANSTETETDNIIYTDINDM 744
                 ||.:::.|  :....:|.:..:|...:..|:                         ::|.
 Frog   590 -----LAISYKQQ--AGRGGTLFSFSLHLPDSFPSL-------------------------LDDD 622

  Fly   745 GHYKYPDFHSSAHQEHKISNSEHLNLNERNDIYATVNRKAKSKIREKHFSDEFIDQSILQYTRAK 809
            |:..:|                  |::|.|                      |:.:|:..|...:
 Frog   623 GYLSFP------------------NISETN----------------------FLPESLQHYLPIR 647

  Fly   810 QMGLSQVP-------VLLQQPSTSAYAAALQ----------ERSYNSGSYQYHNDLNHPSESSSS 857
            ...|  ||       .||....:..||..|.          |....|.|....|||:..|:..:
 Frog   648 SPSL--VPCFLFIFFFLLSASFSVPYALTLSFPLAMCLCYLEPKAVSLSAALDNDLSDSSDDET- 709

  Fly   858 SYFGTGFGTKRYGQSERTKLAQSENYLTPSLDSQSSRHTHSLPRNSELSGVDSVDSYDSH----- 917
                         .||:|..|....  |.:.:|.....|::..:||.:..:...:.|..|
 Frog   710 -------------DSEQTDTAADGE--TTATESDQEEDTYAKTQNSLIKRIKGENVYVKHSNLML 759

  Fly   918 --------YITHHSVGI--LPPGHLSSSSEKLDFQLPSGNLYSTTQFVKP--------EDASAHY 964
                    .:..|...|  |....|.:|::     ..:|..:.......|        |......
 Frog   760 EEFDRNQEELMKHQTNISELKRTFLETSTD-----TTTGGEWEKRLSTSPVRLVMRHEEAPMIEP 819

  Fly   965 MEDEEEEEEDEGENIYDQVERDSWLKSSSCKDLFERYSSTYYDREHSKPMTAFDKEFLSSNRIDS 1029
            :..||.:||.|...|...:||                  |.|....|:|.....|  |...|..|
 Frog   820 LVPEETKEEREKREIQMSLER------------------TSYSMLESQPGDIVKK--LREARATS 864

  Fly  1030 PVTRYDDSRHSLYVAKNHSIDAHQGFSPLPQ------------SKV---------------YSSS 1067
            |            ||.:..|...:.....|:            :||               .||.
 Frog   865 P------------VATSQQIIMQKTIPTSPEGTEDWVIIDKVPTKVVDGETKTIVTYKVTTVSSD 917

  Fly  1068 YPGSTYNTQEHKRQ--HGHHMDYSGSQDDISQDSYELLEKYDIDFFGGRGRSEDHMRSCSLDSGN 1130
            .|..|:.|.....|  ....|:....::|.....|.|            |||.|.:      ||.
 Frog   918 MPAGTFKTSPLGGQSLDALKMELKSKEEDSKLKMYTL------------GRSYDTV------SGK 964

  Fly  1131 YIPSDDESVSEGHQQHKYRSEMDVKSKSAADIMNEI--------WDAEDP------RYLPREKLS 1181
            .:....:: .||.:: |..|..::..|...||...|        ::..:|      |.:| |...
 Frog   965 VVTMTSKA-KEGDKE-KTPSSFEIIQKLEKDIAETIKIAPGTGDYEILEPISDDKGRKVP-EGPP 1026

  Fly  1182 VKSDGNFYKKIQEALVRTSSLESQ--SEMFET-KISRSSDSSKKSRDSLYHTDSKKSRETTKSKT 1243
            ||      :::.|.|......:||  |.:.|| |..:..|:.|...:|:....:::.::....|.
 Frog  1027 VK------RRMSETLTPIKESDSQLASPVEETLKKVQDKDTEKNLIESVIFGKAEQFQDYDVIKA 1085

  Fly  1244 SVASSQDSKESLVGDCFGRNYEMPTTTGKKVKQFTKKELYEKFAQSSQESK---SDYYDAVETGL 1305
            .|.|.:|.|  |....:.|:......|...|.:.:..::..|  |||.|..   ||.|..:|
 Frog  1086 DVPSWKDKK--LSEWRYTRDQPFTIATAHYVTESSASKVVTK--QSSGEKTLEGSDIYSLLE--- 1143

  Fly  1306 EHTPEGLYSRPKVKSHDCLLSDTHSSTANSSFYDSRDTYSTFPSNKTHKTSKVHSISLQNVEIER 1370
                                    |:...|.|.....:.|...:.||..|::..|.|....:.|:
 Frog  1144 ------------------------STRKPSEFLGEVTSTSQSWAQKTETTTEWDSSSKGQEDAEQ 1184

  Fly  1371 NAKSFGSKSPESVSTPASGKRCREKDIQTGDSLDQMAPIKRGNSQSCKISAFRRRSDSENIFSFD 1435
            .||                    ||.:|...||::..           :.:.....|:..:..
 Frog  1185 KAK--------------------EKVVQGMVSLEESL-----------VGSVHASRDAAELAG-- 1216

  Fly  1436 QDRIECIQKYTKQWEGQQPKDEKSKQSPEYPLTPELVSEF-EKQQARLMAHQKITRK---EELIA 1496
                ..|....|..||...|.|     ||..|..:..:.: :::|.....|:.:..|   |..:.
 Frog  1217 ----TVIASSLKGDEGSTLKKE-----PEEDLAVDASACYAQEEQHGSKVHELLDGKPQVESPVV 1272

  Fly  1497 KTHFEEYNPIM-----------VP--------LNYSSHATVERTKSDPNSLANRARL-----GSN 1537
            ||....:..|.           ||        :.|.|.....||.:||..|.:...:     |:.
 Frog  1273 KTEIITFGTIADGEKPDISTKDVPVVHTETKTITYESSELGSRTDTDPGMLMSAQTITSETFGTT 1337

  Fly  1538 SRRHV 1542
            :..|:
 Frog  1338 TTTHI 1342

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cdep	NP_001097685.2	B41	70..264	CDD:214604	80/193 (41%)
		FERM_C_FARP1-like	251..372	CDD:270014	44/120 (37%)
		FA	364..404	CDD:462582	17/51 (33%)
		GAPT	<1240..1299	CDD:463345	16/61 (26%)
		PTZ00121	<2219..2716	CDD:173412
epb41l3	XP_017950527.2	B41	112..301	CDD:214604	80/192 (42%)
		FERM_C_4_1_family	296..389	CDD:270005	37/92 (40%)
		FA	398..441	CDD:462582	17/51 (33%)
		SAB	758..806	CDD:461285	7/52 (13%)
		4_1_CTD	1293..1399	CDD:461774	11/50 (22%)