DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cdep and farp2

DIOPT Version :9

Sequence 1:	NP_001097685.2	Gene:	Cdep / 40608	FlyBaseID:	FBgn0265082	Length:	4273	Species:	Drosophila melanogaster
Sequence 2:	XP_009300696.1	Gene:	farp2 / 567490	ZFINID:	ZDB-GENE-030131-2993	Length:	1051	Species:	Danio rerio

Alignment Length:	1026	Identity:	296/1026 - (28%)
Similarity:	453/1026 - (44%)	Gaps:	210/1026 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 PVGGGLPGGRMT--------HSLSTPSGVDGTPSTPRHRG-GKKLTVRIQMLDDSITMFQVQAKA 89
            |.|..|.|...|        .|||:..|..|       :| .|.|.:|:|.||::...:::::||
Zfish    14 PAGSRLGGQHNTGISTLEPGQSLSSAMGAGG-------KGHNKGLQIRVQGLDEAQEFYELESKA 71

  Fly    90 LGRVLFEQVCRQLNLLEADYFGLEYQEVSTHTKYWLDLEKPMNRQVGLSLIDPVLRFCIKFYTPD 154
            .|::|...|.|::||:|:||||||:|.:..:. .|||..|.:.:||...: :.:.|..:||:.||
Zfish    72 DGQLLLSDVFRRINLIESDYFGLEFQNLQMNW-VWLDPSKLIVKQVRRPM-NTLFRLSVKFFPPD 134

  Fly   155 PAQLEEEYTRYLFCLQIKRDLATGSLQCNDNTAALMASYIVQASCGDFVPEDYPDHTYLSSYRFV 219
            |.||:||:|||||.|||||||..|.|.|.:|||||:||::||:..||:  :|..|..:|...:.:
Zfish   135 PGQLQEEFTRYLFSLQIKRDLLDGRLSCTENTAALLASHLVQSEIGDY--DDLADREFLKMNKLL 197

  Fly   220 PNQDATMQRKIMENHKKHVGQSPAEADLNLLETARRCELYGMKMHPAKDVEGVPLNLAVAHMGIT 284
            |.|: .:|.||||.|::|.||:|||:|..:||.||:.|::|::.|||.|.||..:||||||||:.
Zfish   198 PCQE-HVQEKIMELHRRHTGQTPAESDFQVLEIARKLEMFGVRFHPAADREGTKINLAVAHMGLQ 261

  Fly   285 VFQNITRINTFSWAKIRKISFKRKRFLVKLHPEGYGYYKDTVEFFFEGRNECKNFWKKCVENHGF 349
            |||..|:||||:|:||||:||||||||:|||||.:|.::||:||....|::||.|||.|||:|.|
Zfish   262 VFQGHTKINTFNWSKIRKLSFKRKRFLIKLHPEVHGPHQDTLEFLMGSRDQCKIFWKNCVEHHSF 326

  Fly   350 FRCTAVQNTPRRKTRVLSRGSSFRYSGKTQKQIIEFVRENYVKRQNFQRSQSFRQGPLNASSRSQ 414
            ||... |..|:.|....||||||||||:||||::|:||::.::|..:||    |...:..|:||.
Zfish   327 FRLLD-QPQPKSKAIFFSRGSSFRYSGRTQKQLVEYVRDSGLRRTPYQR----RNSKIRMSTRSL 386

  Fly   415 SHTYVNSSISANPLLPIDTAAWDYRNQCSDSMTPSLTKKAADTLDRRRDNPIGHMRSQVTAAQVE 479
            :......::|.|..|.....        ..|:|.|.....|.::..|.:.|     :|:    :.
Zfish   387 ASDVPKQNLSFNDSLRTHIP--------PSSITASFQSLHAPSVSMRAETP-----NQL----LH 434

  Fly   480 IYQTKN--YAADSPTSQEEAECSAAGAERQHHSAVAMDKLNSNRSLSP---QGPQSWTSPSHSSH 539
            ::||::  ..|.||..|:..:.::. :......::|:|    :..|||   :||.. .|||....
Zfish   435 LHQTQHQPLRAPSPMKQDPIKTNSQ-STYAFPDSIAID----SPQLSPFNDKGPLC-LSPSFQMS 493

  Fly   540 HQQ---RGPDPARVHPGDHNTGLSHLSHLYSSSTPRRVSVGSQAFVPASPQLISINTPSSSTNHN 601
            ...   :.|.|.: .|..:..|.:.|..  .....|:.....:|:..|...|.:..|........
Zfish   494 TLSLPGQAPSPLQ-SPILNEVGTARLDE--DEEGRRKRYPTDKAYFIAKEILTTERTYLKDLEVI 555

  Fly   602 TMHSTSTVVRSVDLNSSMELEEEAEDPGTADTEEEEGEPVGEEEEEELVEEEVDSDLTASTINRE 666
            |:...|.|::           |.|...|.........:|:.|.....|  :|:|..|
Zfish   556 TVWFRSAVIK-----------ENAMPEGLMTLLFSNIDPIYEFHRGFL--KEIDQRL-------- 599

  Fly   667 TMGAASAAAASASALG-------------------SGLASAHRPQLRSQESQSLTATPVHYSSTN 712
               |.....::|...|                   :|....|...|...|..:.....:......
Zfish   600 ---ALWEGRSNAHVKGDYQRIGDVMLRNMCSLKEFTGYLQKHDEVLTELEKATKRVKKLETVYKE 661

  Fly   713 YSMSKQCMLNNANANSTETETDNIIYTDINDMGHYK-----YPDFHSSAHQEH------------ 760
            :.:.|.|.|          ..:..:...|..:.|||     ....:|..|:::
Zfish   662 FELQKVCYL----------PLNTFLLKPIQRLMHYKLILERLCKHYSPQHRDYDDCKEALKEVAE 716

  Fly   761 ----------KISNSEHLNLNERNDIYATVNRKA---------------KSKIREKHFSDEFIDQ 800
                      ::.|.:.|...:| |:....|..|               |..::::.|   |:..
Zfish   717 IATQLQSSLIRLENFQKLTELQR-DLIGIENLTAPGREFIREGCLYKLTKKGLQQRMF---FLFS 777

  Fly   801 SILQYTRAKQMGLSQVPVLLQQPSTSAYAAALQ---ERSYNSGSY-------------------- 842
            .:|.||.......:|..|..|.|........|.   |.|.|..|.
Zfish   778 DMLLYTSKGVTATNQFKVHGQLPLHGMILIVLDAPVEESENEWSVPHCFTIYSAQRTIVVAASSK 842

  Fly   843 ----QYHNDLNHPSESSSSSYFGTGFGTKRYGQSERTKLAQSENYLTPSLDSQSSRHTH--SLPR 901
                ::..|||...|.|....                  .:|:..|.|||..:|:|.:.  ||.:
Zfish   843 VEMNKWIEDLNMAIEMSKKCQ------------------EKSDVLLDPSLCDRSNRSSDEVSLEQ 889

  Fly   902 NSELSGVDSVDSYD--SHYITHHSVGILPPGHLSSSSEKLDFQLPSGNLYS 950
            .||.....|..|.|  ||:..:.::.:.  .|.::|....|..|...|..|
Zfish   890 ESEDDMNSSRCSLDKQSHHRANTTMHVC--WHRNTSVSMSDHSLAVENQLS 938

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cdep	NP_001097685.2	B41	70..264	CDD:214604	86/193 (45%)
		FERM_N	73..134	CDD:286467	23/60 (38%)
		FERM_B-lobe	163..256	CDD:271216	48/92 (52%)
		FERM_C_FARP1-like	251..372	CDD:270014	70/120 (58%)
		FA	364..406	CDD:285894	21/41 (51%)
farp2	XP_009300696.1	B41	53..241	CDD:214604	86/192 (45%)
		FERM_N	55..118	CDD:286467	25/63 (40%)
		FERM_M	138..241	CDD:278785	53/105 (50%)
		FERM_C_FARP1-like	228..348	CDD:270014	70/120 (58%)
		FA	341..382	CDD:285894	21/44 (48%)
		RhoGEF	537..720	CDD:279015	31/216 (14%)
		PH1_FARP1-like	747..861	CDD:269928	21/116 (18%)
		PH	755..857	CDD:278594	18/104 (17%)
		PH2_FARP1-like	933..1030	CDD:270055	2/6 (33%)
		PH	938..1031	CDD:278594	1/1 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	124	1.000	Domainoid score	I5462
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H8877
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm24630
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR45858
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5540
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	6.040