Protein Alignment Cdep and Epb41

DIOPT Version :10

• Sequence 1: NP_001097685.2
• Gene: Cdep / 40608
• FlyBaseID: FBgn0265082
• Length: 4273
• Species: Drosophila melanogaster
• Sequence 2: XP_006538970.1
• Gene: Epb41 / 269587
• MGIID: 95401
• Length: 1025
• Species: Mus musculus
• Alignment Length: 779
• Identity: 221/779 - (28%)
• Similarity: 334/779 - (42%)
• Gaps: 167/779 - (21%)

  Fly    62 RHRGGKKLTVRIQMLDDSITMFQVQAKALGRVLFEQVCRQLNLLEADYFGLEYQEVSTHTKYWLD 126
            |||   .:..::.:|||::....|:..|.|:.|.::||..|||||.|||||...:.:| :|.|||
Mouse   207 RHR---NMHCKVSLLDDTVYECVVEKHAKGQDLLKRVCEHLNLLEEDYFGLALWDSAT-SKTWLD 267

  Fly   127 LEKPMNRQV-GLSLIDPVLRFCIKFYTPDPAQLEEEYTRYLFCLQIKRDLATGSLQCNDNTAALM 190
            ..|.:.:|| |   :.....|.:|||.||||||.|:.|||..|||:::|:..|.|.|:..|.||:
Mouse   268 SAKEIKKQVRG---VPWNFTFNVKFYPPDPAQLTEDITRYYLCLQLRQDIVAGRLPCSFATLALL 329

  Fly   191 ASYIVQASCGDFVPEDYPDHTYLSSYRFVPNQDATMQRKIMENHKKHVGQSPAEADLNLLETARR 255
            .||.:|:..||:.||.: ...|:|.::..|||...::.|:||.||.:...:||:|||..||.|::
Mouse   330 GSYTIQSELGDYDPELH-GMDYVSDFKLAPNQTKELEEKVMELHKSYRSMTPAQADLEFLENAKK 393

  Fly   256 CELYGMKMHPAKDVEGVPLNLAVAHMGITVFQNITRINTFSWAKIRKISFKRKRFLVKLHPEGYG 320
            ..:||:.:|.|||:|||.:.|.|...|:.|:::..|||.|.|.|:.|||:||..|.:|:.|....
Mouse   394 LSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRINRFPWPKVLKISYKRSSFFIKIRPGEQE 458

  Fly   321 YYKDTVEFFFEGRNECKNFWKKCVENHGFFRCTAVQNTPRRKTRVLSRGSSFRYSGKTQKQIIEF 385
            :|:.|:.|........|..||.|||:|.|||.|:....|  |::.|:.||.|||||:||.|
Mouse   459 HYESTIGFKLPSYRAAKKLWKVCVEHHTFFRLTSTDTIP--KSKFLALGSKFRYSGRTQAQ---- 517

  Fly   386 VRENYVKRQ----------NFQRSQSFR-----QGPLNASSRSQS------HTYVNSSISANPLL 429
                  .||          :|:|:.|.|     .|...|.|..:|      .....|.::..|..
Mouse   518 ------TRQASALIDRPAPHFERTASKRASRSLDGAAAAESTDRSPRPTSAPAIAQSQVTEGPGA 576

  Fly   430 PI-------------------------DTAAWDYRNQCSDSMTPS--------LTKKAADTLDRR 461
            ||                         .|.||......::...|:        |..|..|.:..|
Mouse   577 PIKKTPKEAVKVEEKRGEEPAEPAEPEPTEAWKVEKTHTEVTVPTSNGDQTQKLAGKGEDLIRMR 641

  Fly   462 RDNPIGHMRSQVTAAQVEIYQTKNYAADSPTSQEEAECSAAGAERQHHSAVAMDKLNSNRSLSPQ 526
            :..     |.::....:.|..:.....|...||||.        ::||::::..|.|...|:...
Mouse   642 KKK-----RERLDGENIYIRHSNLMLEDLDKSQEEI--------KKHHASISELKKNFMESVPEP 693

  Fly   527 GPQSWTS--PSHS------------------------SHHQQRGPDPARVHPGDHNTGLSHLSHL 565
            .|..|..  .:||                        |..:..||:.......:....::.....
Mouse   694 RPSEWDKRLSTHSPFRTLNINGQVPTGDGVKKTSILPSGRKVGGPESVNGIRTEEVATVTKGPST 758

  Fly   566 YSSS---TPRRVSVGSQAFV---PASPQLISINTPSSSTNHNTMHSTSTVVRSVDLNSSMELEEE 624
            |.:|   .|::..|.||:.:   |||||.....                   |:.:||....|:|
Mouse   759 YPASEWECPKQSVVPSQSLMTTPPASPQSFGSG-------------------SLSINSKEAEEKE 804

  Fly   625 AEDPGTADTEE----EEGEPVGEEEEE--------------ELVEEEVDSDLTASTINRETMGAA 671
            ....|..|.||    ..||.:|.||:.              :|..|:.||.        |.:|||
Mouse   805 QGAAGYLDAEEMPTGPSGECLGVEEQASAFSFPVTPASCQLQLGGEKADSS--------EELGAA 861

  Fly   672 SAA--AASASALGSGLASAHRPQLRSQESQSLTATPVHYSSTNYSMSKQCMLNNANANSTETET 733
            :..  ..|.|.|.|.:.:.....:||.:...:....|..|.|..::..:....:.....|||:|
Mouse   862 AETLETQSGSFLDSPVGNQFPTLIRSFQPPLVKTQTVTISDTANAVKSEIPTKDVPIVHTETKT 925

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cdep	NP_001097685.2	B41	70..264	CDD:214604	79/194 (41%)
		FERM_C_FARP1-like	251..372	CDD:270014	48/120 (40%)
		FA	364..404	CDD:462582	17/54 (31%)
		GAPT	<1240..1299	CDD:463345
		PTZ00121	<2219..2716	CDD:173412
Epb41	XP_006538970.1	B41	212..402	CDD:214604	79/194 (41%)
		FERM_C_4_1_family	397..490	CDD:270005	39/92 (42%)
		FA	500..543	CDD:462582	17/52 (33%)
		SAB	661..709	CDD:461285	14/55 (25%)
		4_1_CTD	914..1021	CDD:461774	4/12 (33%)