DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cdep and Farp1

DIOPT Version :9

Sequence 1:	NP_001097685.2	Gene:	Cdep / 40608	FlyBaseID:	FBgn0265082	Length:	4273	Species:	Drosophila melanogaster
Sequence 2:	NP_598843.3	Gene:	Farp1 / 223254	MGIID:	2446173	Length:	1048	Species:	Mus musculus

Alignment Length:	1291	Identity:	354/1291 - (27%)
Similarity:	537/1291 - (41%)	Gaps:	353/1291 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 PGGRM----THSLSTPSGVDGTPSTPRHRGGKKLTVRIQMLDDSITMFQVQAKALGRVLFEQVCR 100
            |..|:    ...:||.......|.||   .||.:||:||||||:...|:|..:|.|:|||:.||.
Mouse    10 PASRLGAPENSGISTLERGQKPPPTP---SGKLMTVKIQMLDDTQEAFEVPQRAPGKVLFDAVCN 71

  Fly   101 QLNLLEADYFGLEYQEVSTHTK--YWLDLEKPMNRQVGLSLIDP---VLRFCIKFYTPDPAQLEE 160
            .|||:|.||||||:.:   |.|  .||||.||:.:|:.    .|   |::|.:||:.||..||:|
Mouse    72 HLNLVEGDYFGLEFPD---HRKIVVWLDLLKPIVKQIR----RPKHVVVKFVVKFFPPDHTQLQE 129

  Fly   161 EYTRYLFCLQIKRDLATGSLQCNDNTAALMASYIVQASCGDFVPEDYPDHTYLSSYRFVPNQDAT 225
            |.|||||.||:|:|||.|.|.|||.:|||:.|:|||:..|||  ::..|..:|:..::||.|||
Mouse   130 ELTRYLFALQVKQDLAQGRLTCNDTSAALLISHIVQSEIGDF--DEALDREHLAKNKYVPQQDA- 191

  Fly   226 MQRKIMENHKKHVGQSPAEADLNLLETARRCELYGMKMHPAKDVEGVPLNLAVAHMGITVFQNIT 290
            ::.:|||.|..||||:|||:|..|||.|||.|:||:::|||||.||..:|||||:.||.|||..|
Mouse   192 LEDRIMEFHHSHVGQTPAESDFQLLEVARRLEMYGIRLHPAKDREGTKINLAVANTGILVFQGFT 256

  Fly   291 RINTFSWAKIRKISFKRKRFLVKLHPEGYGYYKDTVEFFFEGRNECKNFWKKCVENHGFFRCTAV 355
            :||.|:|||:||:||||||||:||.|:....|:||:||...||:.||:|||.|||:|.|||...
Mouse   257 KINAFNWAKVRKLSFKRKRFLIKLRPDVNSSYQDTLEFLMAGRDFCKSFWKICVEHHAFFRLFE- 320

  Fly   356 QNTPRRKTRVLSRGSSFRYSGKTQKQIIEFVRENYVKRQNFQRSQSFRQGPLNASSRSQSHTYVN 420
            :..|:.|..:.|||||||:||:||||::::|:|...|:..|:|                .|:.::
Mouse   321 EPKPKPKPVLFSRGSSFRFSGRTQKQVLDYVKEGGHKKVQFER----------------KHSKIH 369

  Fly   421 S--SISANPLLPIDTAAWDYRNQCSDSMTPSLTKKAAD-TLDRRRDNPIGHMRSQVTAAQVEIYQ 482
            |  |:.:.|..|             :|..|..:.::|. |.....::|.|.
Mouse   370 STRSLVSQPTAP-------------NSEVPKQSPQSASLTFGEGTESPGGQ-------------- 407

  Fly   483 TKNYAADSPTSQEEAECSAAGAERQHHSAVAMDKLNSNRSLSPQGPQ----SWTSPSHSSHHQQR 543
                     :.|:..|..|...|...|.:.|:.|       ||.|.:    :...|......::.
Mouse   408 ---------SCQQAKETKACTLELGPHQSPALPK-------SPPGSKAADGTTVVPPEEEEEEEG 456

  Fly   544 GPD---PARVHPGDHN----TGLSHLSHLYSSSTPRRVSVGSQAFVPASPQLISINTPSSSTNHN 601
            |.|   |:...|...:    ||..|||.|         |:.||.  .|:|..::::...|..|..
Mouse   457 GKDGIRPSNPQPPQPSTGSLTGSPHLSEL---------SINSQG--GAAPANVTLSPNLSPDNKQ 510

  Fly   602 TMHSTSTVVRSVDLNSSMELEEEAEDPGTADTEEEEG--------------EPVGEEEEEELVEE 652
            .....|.:           |.::| .|.|.|  ||||              :.|...|...|.:.
Mouse   511 ASPLISPL-----------LNDQA-CPRTDD--EEEGRRKRFPTDKAYYIAKEVSTTERTYLKDL 561

  Fly   653 EVDSDLTASTINRETMGAASAAAASASALGSGLASAHRPQLRSQESQSLTATPVHYSSTNYSMSK 717
            ||.:....||:::|            .::...|.|...|...          |:|...||:....
Mouse   562 EVIASWFQSTVSKE------------DSMPEALKSLIFPNFE----------PLHKFHTNFLKEI 604

  Fly   718 QCML------NNANANSTETETDNIIYTDINDMGHYKYPDFHSSAHQEHKISNSEHLNLNERNDI 776
            :..|      :||:.........:::..:|..|.|.       :||            |.:.::.
Mouse   605 EQRLALWEGRSNAHVRGDYQRIGDVMLKNIQGMKHL-------AAH------------LWKHSEA 650

  Fly   777 YATVNRKAKSKIREKHFSDEFIDQSILQYTRAKQMGLSQVPVLLQQPSTSAYAAALQERSYNSGS 841
            ...:....|...|.:||..:|..|.:. |.......|..:..|:.      |...|:...
Mouse   651 LEALETSIKGSRRLEHFCRDFELQKVC-YLPLNTFLLRPLHRLMH------YKHVLERLC----- 703

  Fly   842 YQYHNDLNHPSESSSSSYFGTGFGTKRYGQSERTKL-AQSENYLTPSLDSQSSRHTHSLPRNSEL 905
              .|:..||           ..|...|...:|.|:: ||....:   :..::.:..|.|.:  :|
Mouse   704 --KHHPPNH-----------ADFRDCRAALAEITEMVAQLHGTM---IKMENFQKLHELKK--DL 750

  Fly   906 SGVDSVDSYDSHYITHHSVGILPPGHLSSSSEKLDFQL------PSGNLYSTTQFVKPEDASAHY 964
            .|:|::.:....:|...|:..|....|   .:::.|..      .|..|.::.||........:.
Mouse   751 IGIDNLVTPGREFIRLGSLSKLSGKGL---QQRMFFLFNDVLLYTSRGLTASNQFKVHGQLPLYG 812

  Fly   965 MEDEEEEEE----------DEGENIY----DQVERDSWLKS-SSCKDLFER--------YSSTYY 1006
            |..||.|||          .:.::|.    .:.|.:.|::. ....||.|:        .:|:..
Mouse   813 MTIEESEEEWGVPHCLTLRGQRQSIIVAASSRSEMEKWMEDIQMAIDLAEKSNGPTPELLASSPP 877

  Fly  1007 DREHSKPMTAFDKEFLSSNRIDSPVTRYDDSRHSLYVAKNHSIDAHQGFSPLPQSKVYSSSYPGS 1071
            |.:.....||.|:|    :..|...:|....|.:          .|:|
Mouse   878 DNKSPDEATAADQE----SEDDLSASRTSLERQA----------PHRG----------------- 911

  Fly  1072 TYNTQEHKRQHGHHMDYSGSQDDIS-----QDSYELLEKY--------------DIDFFGGRGRS 1117
              ||..|.   ..|...|.|..|.|     |.|..||.|:              :...|..:...
Mouse   912 --NTMVHV---CWHRSTSVSMVDFSIAVENQLSGNLLRKFKNSNGWQKLWVVFTNFCLFFYKSHQ 971

  Fly  1118 EDHMRSCSLDSGNY---IPSDDESVSEGHQQHKYRSEMDVKSKSAADIMNEIWDAEDPRYLPREK 1179
            :.|..: ||....|   |||:.|::   |:.:.:                              |
Mouse   972 DSHPLA-SLPLLGYSLTIPSESENI---HKDYVF------------------------------K 1002

  Fly  1180 LSVKSDGNFYKKIQEALVRTSSLESQSE-MFE--TKISRSSDSSKKSRDSLYHTDS 1232
            |..||...:::             ::|| .||  .::.||:.||......|.|.:|
Mouse  1003 LHFKSHVYYFR-------------AESEYTFERWMEVIRSATSSASRAHILSHKES 1045

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cdep	NP_001097685.2	B41	70..264	CDD:214604	101/198 (51%)
		FERM_N	73..134	CDD:286467	33/62 (53%)
		FERM_B-lobe	163..256	CDD:271216	50/92 (54%)
		FERM_C_FARP1-like	251..372	CDD:270014	69/120 (58%)
		FA	364..406	CDD:285894	18/41 (44%)
Farp1	NP_598843.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..37		7/29 (24%)
		B41	41..230	CDD:214604	101/198 (51%)
		FERM_C_FARP1-like	217..337	CDD:270014	69/120 (58%)
		FA	329..371	CDD:370090	19/57 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	361..536		51/258 (20%)
		RhoGEF	544..731	CDD:238091	44/252 (17%)
		PH1_FARP1-like	756..864	CDD:269928	21/110 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	865..907		9/45 (20%)
		PH2_FARP1-like	934..1031	CDD:270055	25/143 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	128	1.000	Domainoid score	I5289
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm43331
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45858
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5540
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.040