Protein Alignment Cdep and Farp1

DIOPT Version :10

• Sequence 1: NP_001097685.2
• Gene: Cdep / 40608
• FlyBaseID: FBgn0265082
• Length: 4273
• Species: Drosophila melanogaster
• Sequence 2: NP_001412704.1
• Gene: Farp1 / 223254
• MGIID: 2446173
• Length: 1278
• Species: Mus musculus
• Alignment Length: 1642
• Identity: 412/1642 - (25%)
• Similarity: 623/1642 - (37%)
• Gaps: 509/1642 - (30%)

  Fly    40 PGGRM----THSLSTPSGVDGTPSTPRHRGGKKLTVRIQMLDDSITMFQVQAKALGRVLFEQVCR 100
            |..|:    ...:||.......|.||   .||.:||:||||||:...|:|..:|.|:|||:.||.
Mouse    10 PASRLGAPENSGISTLERGQKPPPTP---SGKLMTVKIQMLDDTQEAFEVPQRAPGKVLFDAVCN 71

  Fly   101 QLNLLEADYFGLEYQEVSTHTK--YWLDLEKPMNRQVGLSLIDP---VLRFCIKFYTPDPAQLEE 160
            .|||:|.||||||:.:   |.|  .||||.||:.:|:.    .|   |::|.:||:.||..||:|
Mouse    72 HLNLVEGDYFGLEFPD---HRKIVVWLDLLKPIVKQIR----RPKHVVVKFVVKFFPPDHTQLQE 129

  Fly   161 EYTRYLFCLQIKRDLATGSLQCNDNTAALMASYIVQASCGDFVPEDYPDHTYLSSYRFVPNQDAT 225
            |.|||||.||:|:|||.|.|.|||.:|||:.|:|||:..|||  ::..|..:|:..::||.|||
Mouse   130 ELTRYLFALQVKQDLAQGRLTCNDTSAALLISHIVQSEIGDF--DEALDREHLAKNKYVPQQDA- 191

  Fly   226 MQRKIMENHKKHVGQSPAEADLNLLETARRCELYGMKMHPAKDVEGVPLNLAVAHMGITVFQNIT 290
            ::.:|||.|..||||:|||:|..|||.|||.|:||:::|||||.||..:|||||:.||.|||..|
Mouse   192 LEDRIMEFHHSHVGQTPAESDFQLLEVARRLEMYGIRLHPAKDREGTKINLAVANTGILVFQGFT 256

  Fly   291 RINTFSWAKIRKISFKRKRFLVKLHPEGYGYYKDTVEFFFEGRNECKNFWKKCVENHGFFRCTAV 355
            :||.|:|||:||:||||||||:||.|:....|:||:||...||:.||:|||.|||:|.|||...
Mouse   257 KINAFNWAKVRKLSFKRKRFLIKLRPDVNSSYQDTLEFLMAGRDFCKSFWKICVEHHAFFRLFE- 320

  Fly   356 QNTPRRKTRVLSRGSSFRYSGKTQKQIIEFVRENYVKRQNFQRSQSFRQGPLNASSRSQSHTYVN 420
            :..|:.|..:.|||||||:||:||||::::|:|...|:..|:|                .|:.::
Mouse   321 EPKPKPKPVLFSRGSSFRFSGRTQKQVLDYVKEGGHKKVQFER----------------KHSKIH 369

  Fly   421 S--SISANPLLPIDTAAWDYRNQCSDSMTPSLTKKAAD-TLDRRRDNPIGHMRSQVTAAQVEIYQ 482
            |  |:.:.|..|             :|..|..:.::|. |.....::|.|.
Mouse   370 STRSLVSQPTAP-------------NSEVPKQSPQSASLTFGEGTESPGGQ-------------- 407

  Fly   483 TKNYAADSPTSQEEAECSAAGAERQHHSAVAMDKLNSNRSLSPQGPQ----SWTSPSHSSHHQQR 543
                     :.|:..|..|...|...|.:.|:.|       ||.|.:    :...|......::.
Mouse   408 ---------SCQQAKETKACTLELGPHQSPALPK-------SPPGSKAADGTTVVPPEEEEEEEG 456

  Fly   544 GPD---PARVHPGDHNTGLSHLSHLYSSSTPRRVSVGSQAFVPASPQLISINTPSSSTNHNTMHS 605
            |.|   |:...|...:||           ...|.:.||...:|      .|:.....:.::.:..
Mouse   457 GKDGIRPSNPQPPQPSTG-----------PASRAAGGSSNSIP------FIDCSDVDSEYDLLRE 504

  Fly   606 TSTVVRSV-------DLNSSM----------ELEEEAEDPGTADTEEEEGEPVGEEEEEELVEEE 653
            ..:..||.       ||.|.:          |....|..|.|..:....||.:.::      ..:
Mouse   505 PGSQSRSQTNDNYEGDLTSGVYLLSGDERRAETRHRASPPSTKPSRPPSGEFLDDD------SAD 563

  Fly   654 VDSDLTASTINRETMGAASAAAASASALGSGL---ASAHRPQLRSQESQSLTATPVHYSSTNYSM 715
            :..||:.|                     .||   :|......|:....|..|||:...|.:.|
Mouse   564 ITFDLSGS---------------------PGLPRHSSLIDDMFRASTGHSPLATPLSPCSRSSS- 606

  Fly   716 SKQCMLNNANANSTETETDNIIYTDINDMGHYKYPDFH-SSAHQEHKISNSEHLNLNERNDIYAT 779
                                              ||.. .....:..:|.:.| :|.|
Mouse   607 ----------------------------------PDMSWDRTRSQGYVSENGH-DLQE------- 629

  Fly   780 VNRKAKSKIREKHFSDEFIDQSILQYTRAKQMGLSQVPVLLQQPSTSAYAAALQERSYNSGSYQY 844
                                         |.||...||  .|.|                   .|
Mouse   630 -----------------------------KSMGEDTVP--KQGP-------------------PY 644

  Fly   845 HN---DLNHPSESSSSSYFGTGFGTKRYGQSERTKLAQSENYLTPS----LDSQSSRH---THSL 899
            .|   ||..|...:..|         ||.:||...|..|:...||.    .|.|....   ||..
Mouse   645 ENCSPDLPRPYLRNLPS---------RYNKSETDPLILSQAAPTPEAVERFDDQEEEEEGLTHMA 700

  Fly   900 PRNSELSGVDSVDSYDSHYITHHSVGILPPGHLSSSSEKLDFQLPSGNLYSTTQFVKP------E 958
            .....|:|...:..     ::.:|.|...|.:::.|.          ||....:...|      .
Mouse   701 TPQGSLTGSPHLSE-----LSINSQGGAAPANVTLSP----------NLSPDNKQASPLISPLLN 750

  Fly   959 DASAHYMEDEEEEEE-----DEGENIYDQV---ERD---------SWLKSSSCKD--LFERYSST 1004
            |.:....:||||...     |:...|..:|   ||.         ||.:|:..|:  :.|...|.
Mouse   751 DQACPRTDDEEEGRRKRFPTDKAYYIAKEVSTTERTYLKDLEVIASWFQSTVSKEDSMPEALKSL 815

  Fly  1005 YYDREHSKPMTAFDKEFLSSNRIDSPVTRYDDSRHSLYVAKNHSIDAHQGFSPLPQSKVYSSSYP 1069
            .:  .:.:|:..|...||          :..:.|.:|:..:                   |:::.
Mouse   816 IF--PNFEPLHKFHTNFL----------KEIEQRLALWEGR-------------------SNAHV 849

  Fly  1070 GSTY---------NTQEHKRQHGHHMDYSGSQDDISQDSYELLEKYDIDFFGGRGRSEDHMRSCS 1125
            ...|         |.|..|....|...:|           |.||..:....|.| |.|...|...
Mouse   850 RGDYQRIGDVMLKNIQGMKHLAAHLWKHS-----------EALEALETSIKGSR-RLEHFCRDFE 902

  Fly  1126 LDSGNYIPSDDESVSEGHQQHKYRSEMDVKSK----SAADI------MNEIWDAEDPRYLPREKL 1180
            |....|:|.:...:...|:...|:..::...|    :.||.      :.||.:.....:....|:
Mouse   903 LQKVCYLPLNTFLLRPLHRLMHYKHVLERLCKHHPPNHADFRDCRAALAEITEMVAQLHGTMIKM 967

  Fly  1181 SVKSDGNFYK--KIQEALVRTSSLESQSEMFETKISRSSDSSKKSRDSLYHTDSKKSRETTKSKT 1243
            .     ||.|  ::::.|:...:|.:....|....|.|..|.|..:..::...:.....|::..|
Mouse   968 E-----NFQKLHELKKDLIGIDNLVTPGREFIRLGSLSKLSGKGLQQRMFFLFNDVLLYTSRGLT 1027

  Fly  1244 SVASSQDSKESLVGDCFGRNYEMPTTTGKKVKQFTKKELYEKFAQSSQESKSDYYDAVETGLEHT 1308
              ||:|          |..:.::|              ||....:.|:|         |.|:.|
Mouse  1028 --ASNQ----------FKVHGQLP--------------LYGMTIEESEE---------EWGVPH- 1056

  Fly  1309 PEGLYSRPKVKSHDCLLSDTHSSTANSSFYDSRDTYSTFPSNKTHKTSKVHSISLQNVEIERNAK 1373
                          ||           :....|.:.....|:::.....:..|.:   .|:...|
Mouse  1057 --------------CL-----------TLRGQRQSIIVAASSRSEMEKWMEDIQM---AIDLAEK 1093

  Fly  1374 SFG------------SKSPESVSTPASGKRCREKDIQTG-DSLDQMAPIKRGNSQSCKISAFRRR 1425
            |.|            :|||:. :|.|..:  .|.|:... .||::.|| .|||:.   :.....|
Mouse  1094 SNGPTPELLASSPPDNKSPDE-ATAADQE--SEDDLSASRTSLERQAP-HRGNTM---VHVCWHR 1151

  Fly  1426 SDSENIFSF-----DQDRIECIQKYTKQWEGQQPK----------DEKSKQSPE---------YP 1466
            |.|.::..|     :|.....::|: |...|.|..          ..||.|...         |.
Mouse  1152 STSVSMVDFSIAVENQLSGNLLRKF-KNSNGWQKLWVVFTNFCLFFYKSHQDSHPLASLPLLGYS 1215

  Fly  1467 LTPELVSEFEKQQARLMAHQKITRKEELIAKTHFEEYNPIMVPLNYSSHATVERTKSDPNSLANR 1531
            ||  :.||.|.      .|      ::.:.|.||:.:   :......|..|.||...     ..|
Mouse  1216 LT--IPSESEN------IH------KDYVFKLHFKSH---VYYFRAESEYTFERWME-----VIR 1258

  Fly  1532 ARLGSNSRRHVLMHQKS 1548
            :...|.||.|:|.|::|
Mouse  1259 SATSSASRAHILSHKES 1275

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cdep	NP_001097685.2	B41	70..264	CDD:214604	101/198 (51%)
		FERM_C_FARP1-like	251..372	CDD:270014	69/120 (58%)
		FA	364..404	CDD:462582	18/39 (46%)
		GAPT	<1240..1299	CDD:463345	10/58 (17%)
		PTZ00121	<2219..2716	CDD:173412
Farp1	NP_001412704.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..37		7/29 (24%)
		B41	41..230	CDD:214604	101/198 (51%)
		FERM_C_FARP1-like	217..337	CDD:270014	69/120 (58%)
		FA	329..372	CDD:462582	20/58 (34%)
		RhoGEF	774..961	CDD:238091	41/229 (18%)
		PH1_FARP1-like	986..1094	CDD:269928	26/171 (15%)
		PH2_FARP1-like	1164..1261	CDD:270055	23/119 (19%)