DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cdep and frm-3

DIOPT Version :9

Sequence 1:	NP_001097685.2	Gene:	Cdep / 40608	FlyBaseID:	FBgn0265082	Length:	4273	Species:	Drosophila melanogaster
Sequence 2:	NP_001361874.1	Gene:	frm-3 / 186110	WormBaseID:	WBGene00001490	Length:	1091	Species:	Caenorhabditis elegans

Alignment Length:	1339	Identity:	370/1339 - (27%)
Similarity:	550/1339 - (41%)	Gaps:	384/1339 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 PSGVDGTPSTP---RHRGGKKLTVRIQMLDDSITMFQVQAKALGRVLFEQVCRQLNLLEADYFGL 112
            |.|| |.|..|   ..:.|:.:.::::||||::.:|.:..||:|:.|.::|||.|||||.|||||
Worm     5 PRGV-GAPPPPGMNSSKRGRLVCIKVRMLDDTVAVFHLGHKAIGQTLLDEVCRHLNLLECDYFGL 68

  Fly   113 EYQEVS-THTKYWLDLEKPMNRQVGLSLIDPVLRFCIKFYTPDPAQLEEEYTRYLFCLQIKRDLA 176
            .:.::: .|.  |||.||.:.||:.....|....|.:|||||:|..||||||||||.:|||||||
Worm    69 SFIDINGNHC--WLDREKTILRQITNGSTDAKFYFVVKFYTPNPIDLEEEYTRYLFTMQIKRDLA 131

  Fly   177 TGSLQCNDNTAALMASYIVQASCGDFVPEDYPDHTYLSSYRFVPNQDATMQRKIMENHKKHVGQS 241
            .|.|.|:||||:|:::|:||:.||||..|||||.||||..||||||....|:|:|:||:..:|.:
Worm   132 LGELHCSDNTASLLSAYLVQSECGDFSSEDYPDATYLSHTRFVPNQTLEFQKKVMDNHRNFIGMT 196

  Fly   242 PAEADLNLLETARRCELYGMKMHPAKDVEGVPLNLAVAHMGITVFQNITRINTFSWAKIRKISFK 306
            |.|:||.:||.||||:.||:|:|.|||::|....|:|.|:||.||:.:....|||||:|||:|||
Worm   197 PGESDLAMLEVARRCDFYGVKLHAAKDIDGNDAALSVMHLGIKVFRQLQLDTTFSWARIRKLSFK 261

  Fly   307 RKRFLVKLHPEGYGYYKDTVEFFFEGRNECKNFWKKCVENHGFFRCTAVQNTPRRKTR-VLSRGS 370
            ||:.||||||:.|.|.|:||||.||.|:|||||||||||:|.||||...:. |:::|| .:|:||
Worm   262 RKKLLVKLHPDSYQYLKETVEFSFETRDECKNFWKKCVEHHAFFRCVQAEE-PKKETRFFISKGS 325

  Fly   371 SFRYSGKTQKQIIEFVRENYVKRQNFQRSQSFRQGPLNASSRSQSHTYVNSSISANPLLPIDTAA 435
            ||||.|:||||:|::|||::.:|:.|.|       ||.:::.::..||
Worm   326 SFRYHGRTQKQLIDYVREHHKRREPFTR-------PLRSAASTRKGTY----------------- 366

  Fly   436 WDYRNQCSDSMTPSLTKKAADTLDRRRDNPIGHMRSQVTAAQVEIYQTKNYAADSPTSQEEAECS 500
                     |.|..|.          .|.|..|....|    .|..||..|.....|
Worm   367 ---------SSTYGLV----------TDRPTKHRNGSV----YEPNQTDPYNKHQNT-------- 400

  Fly   501 AAGAERQHHSAVAMDKLNSNRSLSPQGPQSWTSPSHSSHHQQRGPDPARVHPG---DHNTGLSH- 561
                    ||::               |......|..:.|...|...|||...   |.:|.::.
Worm   401 --------HSSM---------------PHIAHISSQPADHSFSGTLDARVGKSVTRDPSTSVTQH 442

  Fly   562 -----------LSHLYSSSTPRRVSVGSQAFVPASPQLISINTPSSSTNHNTMHSTSTV-VRSVD 614
                       :|.:.:...|:|.|        ..|...:||..|:|:......|.|.. |.|.|
Worm   443 RLRQLKRSERCISDVDTVERPQRSS--------CRPVSHAINISSTSSKEQPDLSVSLPNVLSDD 499

  Fly   615 LNS-SMELEEEAEDPGTA---------------DTEEEEGEPVGEEEEEELVEEEVDSDLTASTI 663
            |.. ..|:|.|..||..:               |...|:...:.:.|.....|..|.|...|:||
Worm   500 LQMVCKEIEIEQNDPPKSVSGDNFQQRRSSRDYDNVSEDSYRLSDHERSTRSEVGVGSKFAAATI 564

  Fly   664 NRETMGAASAAAASASALGSGLASAHRPQLRSQESQSLTATPVHYSSTNYSMSKQCMLNNANANS 728
            ...|..|                       |...|..:.....|..||              .||
Worm   565 FNSTFVA-----------------------RKPGSNVVKRVVAHTKST--------------PNS 592

  Fly   729 TETETDNIIYTDINDMGHYKYPDFHSSAHQEHKISNSEHLNLNERNDIYATVNRKAKSKIREKHF 793
            |:.|.           |..|              |.||          |.|.          :|
Worm   593 TDDEE-----------GALK--------------SASE----------YQTF----------RH- 611

  Fly   794 SDEFIDQSILQYTRAKQMGLSQVPVLLQQPSTSAYAAALQERSYNSGSYQYHNDLNHPSESSSSS 858
                    |.:|..|:...:  ||:.:..|:....|    .||              |:.::::
Worm   612 --------IKEYPFARNANI--VPIEIDGPNVDLSA----RRS--------------PAATTTT- 647

  Fly   859 YFGTGFGTKRYGQSERTKLAQSENYLTP-----------SLDSQSSRHTHSLPRNSELSGVDSVD 912
                   |:.|..: .|.:..:...||.           |.|.:.|..|||...:.|.....::.
Worm   648 -------TRTYANT-TTTVTTTSKVLTSSGAVLMKPKVISNDHEPSSGTHSSRVSPESGTYGALG 704

  Fly   913 SYDSHYITHHSVGILPPGHLSSSSE-----KLDFQLPSGNLYSTTQFV---KPEDASAHYM---- 965
            ......||..::.|.|.|.....::     |..|  |...::|.|:.|   |.|.||:|.:
Worm   705 PLPGRVITKENMMITPEGFKEKKAKPNPPPKPSF--PVQAVHSETEVVREIKTERASSHPLVHMQ 767

  Fly   966 ------------EDEEEEEEDEGENIYDQVERDSWLKSSSCKDLFER---YSSTYYDREH--SKP 1013
                        ||::|.:..........|:.:.......| .||..   |:.|..:.|:  |.|
Worm   768 EEIPFSRAPLKFEDKKERKSSLSRPALISVQSEDNPDVQKC-HLFNSDIPYTLTMRNVENTQSLP 831

  Fly  1014 MTAF------DKEFLSSNRIDSPVTRYDDSRHSLYVAKNHSIDAHQGFSPLPQSKVYSSSYPGST 1072
            .::|      .|:...||.:..             |:|:......:....:|:.::.|   ||:
Worm   832 YSSFKDVSTAKKQGYESNSLKR-------------VSKSPEFKRRKSLDLVPRKRLPS---PGN- 879

  Fly  1073 YNTQEHKRQHGHHMDYSGSQDDISQDSYELLEKY---DIDFFGGRGRSEDHMRS----------- 1123
            ::.|:|        ..|.:..|.....|.|..:.   |......:.:..|..|.
Worm   880 FSAQDH--------TISPTTPDSDVLEYLLRRRSLLGDKSVIKTKSKRTDPRRQTQPVRFDLPPS 936

  Fly  1124 -CSLDSGNYIP-----SD---DESVSEGHQQHKYRSEMD---VKSKSAADIMNE--IWDAEDPRY 1174
             ||..:|...|     :|   ||.|||....|:....:|   ..::|.:..|::  ..|:||...
Worm   937 PCSPTAGGSTPFISILNDDLFDECVSESRSLHEDMDRLDKTTPHNQSISSFMSQKSRRDSEDSDV 1001

  Fly  1175 LPREKLSVKSDGNFYKKIQEALVRTS----------SLESQSEMFETKISRSSDSSKKSRDSLYH 1229
            :|.....:         :.:|::.:|          ||.:..::.|.|.:.:.        .:|:
Worm  1002 MPPPPEEI---------LNKAMISSSRPAPPPPPPKSLAAAVKVAEMKAAAAG--------KIYY 1049

  Fly  1230 TDSKKSRETTKS--------KTSVASSQDSKESLVGDCF 1260
            :.|.::.:.|.|        |.|.||...|..|...:||
Worm  1050 SGSSRTGKITDSPPFIDDSPKNSSASDAPSVPSPQKNCF 1088

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cdep	NP_001097685.2	B41	70..264	CDD:214604	104/194 (54%)
		FERM_N	73..134	CDD:286467	28/61 (46%)
		FERM_B-lobe	163..256	CDD:271216	56/92 (61%)
		FERM_C_FARP1-like	251..372	CDD:270014	71/121 (59%)
		FA	364..406	CDD:285894	20/42 (48%)
frm-3	NP_001361874.1	B41	26..219	CDD:214604	104/194 (54%)
		FERM_C_FARP1-like	206..327	CDD:270014	71/121 (59%)
		FA	320..>353	CDD:370090	18/32 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	154	1.000	Domainoid score	I2609
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		oto18951
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR45858
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5540
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	6.040