DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cdep and farp1

DIOPT Version :9

Sequence 1:	NP_001097685.2	Gene:	Cdep / 40608	FlyBaseID:	FBgn0265082	Length:	4273	Species:	Drosophila melanogaster
Sequence 2:	XP_002935691.2	Gene:	farp1 / 100486945	XenbaseID:	XB-GENE-486840	Length:	1040	Species:	Xenopus tropicalis

Alignment Length:	1228	Identity:	332/1228 - (27%)
Similarity:	511/1228 - (41%)	Gaps:	326/1228 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 PSTPRHRGGKKLTVRIQMLDDSITMFQVQAKALGRVLFEQVCRQLNLLEADYFGLEYQEVSTHTK 122
            |.:|:   ||....::||||:::...:|..:|.|:.|.:.||..|||:|.||||||:|:   |.|
Frog    32 PLSPQ---GKIYPFKVQMLDETLETVEVPIRAPGKALLDAVCSHLNLVEGDYFGLEFQD---HRK 90

  Fly   123 --YWLDLEKPMNRQVGLSLIDPVLRFCIKFYTPDPAQLEEEYTRYLFCLQIKRDLATGSLQCNDN 185
              .||||.||:.:|:.... :.||:|.:||:.||..||:||.|||||.||:|:||..|.|.||::
Frog    91 IMVWLDLLKPIVKQIRRPK-NVVLKFVVKFFPPDHTQLQEELTRYLFALQVKQDLVQGKLTCNES 154

  Fly   186 TAALMASYIVQASCGDFVPEDYPDHTYLSSYRFVPNQDATMQRKIMENHKKHVGQSPAEADLNLL 250
            :|||:.|:|||:..|||  ::..|..:|...:::|.|: .::.||||.|:.|.||:|||:|..||
Frog   155 SAALLISHIVQSEIGDF--DEAGDQDHLQKNKYMPQQE-PLEEKIMELHRNHFGQTPAESDFQLL 216

  Fly   251 ETARRCELYGMKMHPAKDVEGVPLNLAVAHMGITVFQNITRINTFSWAKIRKISFKRKRFLVKLH 315
            |.|||.|:||:::|||||.||..:|||||:.||.|||..|:||.|:|||:||:||||||||:||.
Frog   217 EIARRLEMYGVRLHPAKDREGTKINLAVANTGILVFQGHTKINAFNWAKVRKLSFKRKRFLIKLR 281

  Fly   316 PEGYGYYKDTVEFFFEGRNECKNFWKKCVENHGFFRCTAVQNTPRRKTRVLSRGSSFRYSGKTQK 380
            |:....|:||:||....|:.||:|||.|||.|.|||... :..|:.|..:.|||||||:||:|||
Frog   282 PDANSSYQDTLEFMMASRDFCKSFWKICVEYHAFFRLFE-EPKPKPKPVLFSRGSSFRFSGRTQK 345

  Fly   381 QIIEFVRENYVKRQNFQRSQSFRQGPLNASSRSQSHTYVNSSISANPLLPI----DTAAWDYRNQ 441
            |::::|||...|:..|:|..|     ...|.|||      ||....|||.:    ....::..:|
Frog   346 QVLDYVREGGHKKVQFERKHS-----KICSIRSQ------SSHHPEPLLEVPKQSSKITFEQISQ 399

  Fly   442 CSDSMTPSLTKKAADTLDRR-RDNPIGHMRSQVTAAQVEIYQTKNYAADSPTSQEEAECSAAGAE 505
            ..:..|....::     |:| .|.|:.|.......:.|           :..::|:.:.:|.|.:
Frog   400 PDEIQTLQQVRE-----DKRVIDVPVQHRSPSPKKSPV-----------ARRAKEDTDVTADGED 448

  Fly   506 RQHHSAVAMDKLNSNRSLSPQGPQSWTSPSHSSHHQQRGPDPARVHPGDHNTGLSHLSHLYSSST 570
                  .|.|  ::.:||.            ::|....|          ..||..|||.|
Frog   449 ------AAKD--HAQKSLK------------NTHQPSTG----------SLTGSPHLSEL----- 478

  Fly   571 PRRVSVGSQAFVPASPQLISINTPSSSTNHNTMHSTSTVVRSVDLNSSMELEEEAEDPG--TADT 633
                |:.||.      .:|.:| ||.|.|.:.....|:.:.|..||          :|.  ..|.
Frog   479 ----SINSQG------GMIGLN-PSLSPNLSPDGKPSSPLISPLLN----------EPACIRTDD 522

  Fly   634 EEEEGEPVGEEEEEELVEEEVDS-------DLTASTINRETMGAASAAAASASALGSGLASAHRP 691
            |||..:.....::...:.:||.:       ||...|...:.      |.....|:...|.:...|
Frog   523 EEESRKKKCPTDKAYFIAKEVSTTECTYLKDLEVITKWFQN------AVGKDDAMPESLRNLIFP 581

  Fly   692 QLRSQESQSLTATPVHYSSTNYSMSKQCML------NNANANSTETETDNIIYTDINDMGHYKYP 750
            ..          .|:|...|::.......|      :|::..:...:..:::..:|..|   |..
Frog   582 NF----------DPLHKFHTSFLKEIDQRLSFWEGRSNSHMKADNQKIGDVMLKNIQGM---KQL 633

  Fly   751 DFHSSAHQEHKISNSEHLNLNERNDIYATVNRKAKSKIREKHFSDEFIDQSILQYTRAKQMGLSQ 815
            ..|...|.|..|...:.:.          .:||.:|..||              :.:.|...|..
Frog   634 TTHLQKHYEALIELEKAIK----------GSRKLESLCRE--------------FEQEKVCYLPL 674

  Fly   816 VPVLLQQPSTSAYAAALQERSYNSGSYQYHNDLNHPSESSS-----------SSYFGTGFGTKRY 869
            ....||......:...:.||...      |...||.....|           :...||....:.:
Frog   675 NTFFLQPLHRLMHYKQIMERLCK------HYPPNHVDFRDSRAALAEITELVAQLHGTMIKMENF 733

  Fly   870 G--QSERTKLAQSENYLTPSLDSQSSRHTHSLPRNSELSG----------VDSVDSYDSHYITHH 922
            .  |..|..|...:|.:||      .|....|...|:|||          .:.|..|.|..:|
Frog   734 QKLQELRKDLTGMDNLVTP------GREFIRLGSLSKLSGKGLQQRMFFLFNDVMIYTSRGLT-- 790

  Fly   923 SVGILPPGHLSSSSEKLDFQLPSGNLYSTTQFVKPEDASAHYMEDEEEEEEDE---GENIYDQVE 984
                      ||:..|:..|||   |::.|                .||.|||   ...:..:.:
Frog   791 ----------SSNQFKVHGQLP---LFNMT----------------IEESEDEWGVPHCLTLRSQ 826

  Fly   985 RDSWLKSSSCKDLFERYSSTYYDREHSKPMTAFDKEFLSSNRIDSPVTRYDDSRHSLYVAKNHSI 1049
            ..:.:.::|.:...|::|                                :|.:.::.:|:..|
Frog   827 NQAIIVAASARPEMEKWS--------------------------------EDIQMAIDLAEKSS- 858

  Fly  1050 DAHQGFSPLPQSKVYSSSYP-------GSTYNTQEH---------KRQHGH----------HMDY 1088
                  .|:|:  :.:||.|       |.|....|.         :||..|          |.:.
Frog   859 ------GPVPE--LLASSPPDGKTPEEGPTDQESEDDLSASRTSLERQSPHRGNTTVHVCWHRNT 915

  Fly  1089 SGSQDDIS-----QDSYELLEKY--------------DIDFFGGRGRSEDHMRSCSLDSGNY--- 1131
            |.|..|.|     |.|..||.|:              :...|..:...:.|..: ||....|
Frog   916 SVSMIDFSFAVENQFSGNLLRKFKNSNGWQKLWVVFTNFCLFFYKSHQDSHPLA-SLPLLGYSLT 979

  Fly  1132 IPSDDESVSEGH------QQHKY--RSEMDVKSKSAADIMNEIWDAEDPRYLPREKLS 1181
            |||:.|::.:.:      :.|.|  |:|.:.......:::....|:....:|...|.|
Frog   980 IPSESENIHKDYVFKLHFKSHVYYFRAENEYTFDRWMEVIRSATDSASRSHLLSRKES 1037

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cdep	NP_001097685.2	B41	70..264	CDD:214604	90/195 (46%)
		FERM_N	73..134	CDD:286467	29/62 (47%)
		FERM_B-lobe	163..256	CDD:271216	45/92 (49%)
		FERM_C_FARP1-like	251..372	CDD:270014	68/120 (57%)
		FA	364..406	CDD:285894	20/41 (49%)
farp1	XP_002935691.2	FERM_F1_FARP1	40..124	CDD:340709	36/87 (41%)
		FERM_M	127..230	CDD:395297	52/105 (50%)
		FERM_C_FARP1-like	217..337	CDD:270014	68/120 (57%)
		FA	329..367	CDD:400882	20/42 (48%)
		RhoGEF	537..724	CDD:238091	36/235 (15%)
		PH1_FARP1-like	749..857	CDD:269928	30/176 (17%)
		PH2_FARP1-like	926..1023	CDD:270055	18/97 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	120	1.000	Domainoid score	I5678
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm48480
Panther	1	1.100	-	-	O	PTHR45858
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.010