DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gnf1 and atad5a

DIOPT Version :9

Sequence 1:	NP_001014605.1	Gene:	Gnf1 / 40607	FlyBaseID:	FBgn0004913	Length:	1008	Species:	Drosophila melanogaster
Sequence 2:	XP_003198157.2	Gene:	atad5a / 560591	ZFINID:	ZDB-GENE-070912-20	Length:	1778	Species:	Danio rerio

Alignment Length:	1017	Identity:	174/1017 - (17%)
Similarity:	309/1017 - (30%)	Gaps:	407/1017 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 KAKSAEAENGETPSKAPKRRKAVIISSDED----EVVSPPETKKRKASKTASSEDDVVAATPEPI 75
            ::..||.:|.|.|.:..:|       |..|    :..:.|: ||.|...|.  :||....||.|.
Zfish   479 ESSPAEKDNTEEPVRELRR-------STRDLSRRQTAAAPQ-KKEKQENTV--KDDETQNTPSPS 533

  Fly    76 AKKARNGQKPALSKLKRHVDPTELF------GGETKRVIVPKPKTKAVL--EFENEDIDRSLMEV 132
            .......|:|     ||.:...|:.      |...:..|...|.|.|..  :||   |...|...
Zfish   534 LASTPKVQRP-----KRGIYRAEILCPPYTKGSPIRMRISRMPPTSATKAGDFE---ISSPLSAQ 590

  Fly   133 DLDESIKEAAPEK---KVHSITRSSPSPKRAKNSSPEPPKPKSTKSKATT------------PRV 182
            :|:.:.|....:|   |..::.::....|:.|.:     ..:||:||.::            ...
Zfish   591 ELNAAKKRKQAKKLVQKAKALQQNKKDTKKEKET-----VRRSTRSKESSINYCEDEDSIVFLEA 650

  Fly   183 KKEKPAADLESSVLTDEERH----------------------------ERK--RASAVLYQKYKN 217
            .|..|.:..||..:..:.|.                            |:|  |.|||:
Zfish   651 SKSNPVSSQESEKINKKLRSLNEVLGKNASQNKTSKTPAGSKLAPLFVEKKAQRPSAVI------ 709

  Fly   218 RSSCLNPGSKEIPKGSPD---CLSGLTFVVTGVLESMEREEAE---------------------- 257
              |..:..|:|..:.|.|   ..:...|:.:|:.||.:::.|:
Zfish   710 --SIFDDSSREASENSQDDEQFRAKREFLKSGLPESFKKQIAKTAANREAYSQACASFQTVVHVQ 772

  Fly   258 -------------------SVIKEYGG-------------KVMTVVGKKLKYLVVG----EEAGP 286
                               |.:||:..             ...||..|:.....|.    |.:.|
Zfish   773 QKTPDCSVWSLQWPTDPLLSCLKEFCNIPSVPLMCLEKSLGCTTVPAKRTFCKQVSCQKTEFSEP 837

  Fly   287 KKLAVAEELNI--PILSEDGLF--------DLIREKSGIAKQVKEEKKSPKKEHSSEEKGKKEVK 341
            .:..:.|::.|  |.......|        |.|.:.|  |..:::|.|......||:..|:|..:
Zfish   838 IRQCLLEKMRISNPSFPHQRFFTRFIKRREDYILQAS--AADLEDESKESCHAGSSDAVGRKRKR 900

  Fly   342 TSRRSSDKKEKEATKLKY------------------------GEKHDIAKHKVKEEHTSPKETKD 382
            .....:..|..:.||..:                        |.:....:.|.||| :.|::...
Zfish   901 VDEGEATGKIGKKTKSSHTDDDVIVIEVSPPSRGEAAQPSGRGRRGRSLRQKQKEE-SKPEDQTS 964

  Fly   383 KLND-----VPAVTLKVKKEPSSQKEHPPSPRTADLKTLDVVGMAWVDKHKPTSIKEIVGQAGAA 442
            .:||     .|||:.....|...:::                 :.|.:|::|....||:|
Zfish   965 PVNDDVMIVEPAVSRNTSTEDGIKED-----------------VLWTEKYQPQHSSEIIG----- 1007

  Fly   443 SNVTNHNLKLKAKQERVKVLHYFNFPRLMNWLSKWYVNHDGNKKPQRP---------NPWAKNDD 498
                        ..|.|:.||        :||.:|.:..|..::.::.         :.|..::|
Zfish  1008 ------------NMESVRRLH--------SWLKEWKLRADREERRKQQEKKHEEDSNDSWLMSED 1052

  Fly   499 -----GSFYKAALLSGPPGIGKTTTATLVVKELGFDAVEFNASDTRSKRLLKDEV---------- 548
                 .......|::||.|:|||.......:||||...|.|:|..||.|.:..::
Zfish  1053 LDETEDFLCNTLLITGPTGVGKTAAVYACAQELGFKVFEVNSSSQRSGRQILSQLKEATQSHQVD 1117

  Fly   549 ------------STLLSNK------------------------------------------SLSG 559
                        |...||.                                          ||:.
Zfish  1118 IQGVNAHKPSYFSNYSSNSATVKPGTSPRKLNSPRRVVSSPRKPPQSPRSASSRRGGLAPTSLTS 1182

  Fly   560 YFTGQGQAVSRK--------------------------------------------------HVL 574
            :|...|::..::                                                  .::
Zfish  1183 FFKAGGRSSGKEVNNQDKKTQPACPKKSAKAKEADDKSKVCPSGTSVGSKISSEDQAKRTATSLI 1247

  Fly   575 IMDEVDGMAGNEDRGGMQELIALIKDSSIPIICMCNDRNHPKIRSLVNYCYD-----LRFQRPRL 634
            :.:||| :..::|.|.:..:...:..:..|:|...:|       |.....:|     :.|:.|.:
Zfish  1248 LFEEVD-IVFDDDLGFLAAIKTFMTTTKRPVILTTSD-------STFGAMFDGQFEEIHFKSPSV 1304

  Fly   635 EQIKGKIMSICFKEKVKISPAKVEEIIAATNNDIRQSINHI--------------ALLSAKEDAS 685
            ..:...:..:|..|.::.....|..::.....|||||:..:              .|.|::....
Zfish  1305 ADVSSYVRLLCLAENLRTDSKDVSCLLEWNGCDIRQSLLQLQFWACSGGVQQIQRPLPSSESKGK 1369

  Fly   686 QKSG---QQVATKDLKLGPWEVVRKVFTADE---HKHMSFAD 721
            .|||   |.|..:|:|             :|   |.|.:|.:
Zfish  1370 PKSGTDLQPVKAEDVK-------------EENLPHCHTAFTE 1398

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gnf1	NP_001014605.1	COG5275	<151..358	CDD:227600	53/319 (17%)
		BRCT	232..309	CDD:278934	21/147 (14%)
		PRK04195	421..969	CDD:235250	73/454 (16%)
		AAA	506..633	CDD:278434	35/245 (14%)
		RFC1	764..917	CDD:285691
atad5a	XP_003198157.2	P-loop_NTPase	1064..>1109	CDD:304359	17/44 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5275
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900