DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gnf1 and Crlf3

DIOPT Version :9

Sequence 1:	NP_001014605.1	Gene:	Gnf1 / 40607	FlyBaseID:	FBgn0004913	Length:	1008	Species:	Drosophila melanogaster
Sequence 2:	NP_061246.1	Gene:	Crlf3 / 54394	MGIID:	1860086	Length:	442	Species:	Mus musculus

Alignment Length:	306	Identity:	63/306 - (20%)
Similarity:	113/306 - (36%)	Gaps:	90/306 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   317 KQVKEEKKSPK---KEHSSEEKGK-------------KEVKTSRRSSDKKEKEATKL-KYG--EK 362
            :|:||.....:   |:|.|:.||.             :||.|..:.:.|...:..|| ::|  ..
Mouse    42 RQIKESASQTRDVLKQHFSDLKGTLGKLLDERLVTLLQEVDTIEQETIKPLDDCQKLIEHGVNTA 106

  Fly   363 HDIAKH-------KVKEE-----HTSPKETKDKLNDVPAVTLKVKKEPSSQKEHPPSPRTADLKT 415
            .|:.:.       .::||     :.:.|.:..:|:.:|.|.|.|        :.|......|...
Mouse   107 DDLVREGEIAILGGIEEESDKLWNFTKKASHIQLDSLPEVPLLV--------DVPCLSAQLDDSI 163

  Fly   416 LDVVGMAWVDKH------KPTSIKEIVGQAGAA--------SNVTNHNLKLKAKQ------ERVK 460
            |::| ...:.||      .|..|:|::.:.|..        .:.|..:.:|:.::      |.|.
Mouse   164 LNIV-KDHIFKHGTVASRPPVQIEELIEKPGGIIVRWCKVDDDFTAQDYRLQFRKCTANHFEDVY 227

  Fly   461 VLHYFNFPRL-----MNWLSKWYVNHDGNKKPQRPNPWAKNDDGSFYKAALLSGPPGIGKTTTAT 520
            |.....|..|     :::..:.....||.   |..:||:                  :.:|..:|
Mouse   228 VGSETEFIVLHIDPNVDYQFRVCARGDGR---QEWSPWS------------------VPQTGHST 271

  Fly   521 LVVKE--LGFDAVEFNASDTRSKRLLKDEVSTLLSNKSLSGYFTGQ 564
            ||..|  .||:.  ::.|..|:..|..|..|:.:...|...||.||
Mouse   272 LVPHEWTTGFEG--YSLSSRRNIALRNDAESSGVLYSSAPTYFCGQ 315

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gnf1	NP_001014605.1	COG5275	<151..358	CDD:227600	14/57 (25%)
		BRCT	232..309	CDD:278934
		PRK04195	421..969	CDD:235250	35/171 (20%)
		AAA	506..633	CDD:278434	17/61 (28%)
		RFC1	764..917	CDD:285691
Crlf3	NP_061246.1	iSH2_PI3K_IA_R	17..113	CDD:304922	16/70 (23%)
Crlf3	NP_061246.1	FN3	181..267	CDD:238020	16/106 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23389
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100