DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gnf1 and CRLF3

DIOPT Version :9

Sequence 1:	NP_001014605.1	Gene:	Gnf1 / 40607	FlyBaseID:	FBgn0004913	Length:	1008	Species:	Drosophila melanogaster
Sequence 2:	NP_057070.3	Gene:	CRLF3 / 51379	HGNCID:	17177	Length:	442	Species:	Homo sapiens

Alignment Length:	306	Identity:	64/306 - (20%)
Similarity:	111/306 - (36%)	Gaps:	90/306 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   317 KQVKEEKKSPK---KEHSSEEKGK-------------KEVKTSRRSSDKKEKEATKL-KYG--EK 362
            :|:||.....:   |:|.::.||.             :||.|..:.:.|...:..|| ::|  ..
Human    42 RQIKESASQTRDVLKQHFNDLKGTLGKLLDERLVTLLQEVDTIEQETIKPLDDCQKLIEHGVNTA 106

  Fly   363 HDIAKH-------KVKEEHT-----SPKETKDKLNDVPAVTLKVKKEPSSQKEHPPSPRTADLKT 415
            .|:.:.       .|.||:.     :.|.:..:|:.:|.|.|.|        :.|......|...
Human   107 EDLVREGEIAMLGGVGEENEKLWSFTKKASHIQLDSLPEVPLLV--------DVPCLSAQLDDSI 163

  Fly   416 LDVVGMAWVDKH------KPTSIKEIVGQAGAA--------SNVTNHNLKLKAKQ------ERVK 460
            |::| ...:.||      .|..|:|::.:.|..        .:.|..:.:|:.::      |.|.
Human   164 LNIV-KDHIFKHGTVASRPPVQIEELIEKPGGIIVRWCKVDDDFTAQDYRLQFRKCTSNHFEDVY 227

  Fly   461 VLHYFNFPRL-----MNWLSKWYVNHDGNKKPQRPNPWAKNDDGSFYKAALLSGPPGIGKTTTAT 520
            |.....|..|     :::..:.....||.   |..:||:               .|.||.   :|
Human   228 VGSETEFIVLHIDPNVDYQFRVCARGDGR---QEWSPWS---------------VPQIGH---ST 271

  Fly   521 LVVKE--LGFDAVEFNASDTRSKRLLKDEVSTLLSNKSLSGYFTGQ 564
            ||..|  .||:.  ::.|..|:..|..|..|:.:.......||.||
Human   272 LVPHEWTAGFEG--YSLSSRRNIALRNDSESSGVLYSRAPTYFCGQ 315

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gnf1	NP_001014605.1	COG5275	<151..358	CDD:227600	13/57 (23%)
		BRCT	232..309	CDD:278934
		PRK04195	421..969	CDD:235250	36/171 (21%)
		AAA	506..633	CDD:278434	18/61 (30%)
		RFC1	764..917	CDD:285691
CRLF3	NP_057070.3	FN3	181..265	CDD:238020	16/101 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23389
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100