DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gnf1 and elg1

DIOPT Version :9

Sequence 1:	NP_001014605.1	Gene:	Gnf1 / 40607	FlyBaseID:	FBgn0004913	Length:	1008	Species:	Drosophila melanogaster
Sequence 2:	NP_595265.1	Gene:	elg1 / 2541276	PomBaseID:	SPBC947.11c	Length:	920	Species:	Schizosaccharomyces pombe

Alignment Length:	985	Identity:	187/985 - (18%)
Similarity:	341/985 - (34%)	Gaps:	270/985 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 ISSDEDEVVSPPETKKRKASKTASSEDDVVAATPEPIAKKARNGQKPALSKLKRHVDPTELFGGE 103
            :|:|..   |.|:.|         ||::  |...:||.::......||.|: .::...:.|.|..
pombe     7 LSADSQ---SNPDLK---------SENE--AKEEKPIGRRHTMSPVPATSE-NKYFGKSPLSGSR 56

  Fly   104 TKRVIVPKPKTKAVLEFENEDIDRSLMEVDLDESIKEAAPEKKVHSITRSSPS----------PK 158
                   ||:....|..|...: |...::|::|| |:...::.:....:.|.|          ||
pombe    57 -------KPRRSRSLHKERSYM-RKFFDMDMEES-KDFENDQSLLVTLKVSTSLGQKIENILHPK 112

  Fly   159 RAK--NSSPEPPKPKSTKSKATTPRVKKEKPAADLESSVLTDEERHERKRASAVLYQKYKNRSSC 221
            .:.  ||:..||...|.::..|...|:.......:.||.|..|..:.....|.   ...:|..:.
pombe   113 LSNDTNSTAFPPAKSSGEASDTNILVENINSQETVNSSPLVSELHYSNLADSP---SNLRNTVTS 174

  Fly   222 LNP--GSKEIPKGSPDCLSGLTFVVTGVLESMEREEAESVIKEYGGKVMTVVGKKLKYLVVGEEA 284
            ::|  .||.:.|.|                                        ::|:  |.||.
pombe   175 MHPFFMSKSVKKNS----------------------------------------EIKF--VSEER 197

  Fly   285 GPKKLAVAEELNIPILSEDGLFDLIREKSGIAKQVKEEKKSPKKEHSSEEKGK---KEVKTSRRS 346
            |..|   .|.|..|:........::.....|...|....|...:|...||...   |||.:|..:
pombe   198 GGTK---PERLLDPLWPTPDSQSMLEYAGSIEPSVFWFPKKHLEEAILEETSHLSFKEVLSSTTA 259

  Fly   347 ------SDKKEKEATKLKYGEKHDIAKHKVKEEHTSPKETKDKLNDVPAVTLKVKKEPSSQK--- 402
                  ::|.:.|..::                      |..||:.....:|.....|..||
pombe   260 NMITPLAEKNKTEVLQV----------------------TPSKLHTFALESLCFSPAPFIQKVLS 302

  Fly   403 ---------EHPPSPRTADLKTLDVVGMAWVDKHKPTSIKEIVGQAGAASNVTN--HNLKLKAKQ 456
                     |.|..|:..: |.|      ||.|:.|:..::....:...|.:.:  .:.:|...:
pombe   303 RLLPSDPNVEMPMIPQILE-KGL------WVSKYAPSKTQDCCAFSQCLSKIADWLRSCRLTKPE 360

  Fly   457 ----------ERVKVLHYFNFPRLMNWLSKWYVNHDG-NKKPQRPNPWAKNDD------------ 498
                      .|...:|.....:.         |.|. ::....|:...:.||
pombe   361 SSSVPPSSSISRSSTIHSCTSSKR---------NEDSLSESDFEPDIIEEEDDSDEFNPSVSRKK 416

  Fly   499 -----GSFYKAALLSGPPGIGKTTTATLVVKELGFDAVEFNASDTRSKRLLKDEVSTLLSNKSLS 558
                 ..|....|::|..|||||:....:.:||.|:.||.:....||.:.|.:.:..|.
pombe   417 AKLTSSQFSNWMLVTGVTGIGKTSCLYAICRELNFEVVEIHPGMRRSGKELLERIGELT------ 475

  Fly   559 GYFTGQGQAVSRKH-------VLIMDEVDGMAGNEDRGGMQELIALIKDSSIPIICMCNDRNH-P 615
                 |...|.:..       :::::||| :...:|||..|.:..||:.|..|::..||:.:. |
pombe   476 -----QSHIVDKSRLNNTPDILILLEEVD-ILFQDDRGFWQAVSTLIEKSKRPVVMTCNETDFLP 534

  Fly   616 KIRSLVNYCYDLRFQRPRLEQIKGKIMSICFKEKVKISPAKVEEIIAATNNDIR---QSINHIAL 677
            .  :.:...:.::||......:...|.|:.:.::..||...||.|.....:|:|   ..:|..:|
pombe   535 S--AFLQEDHIVQFQSISSALLTDYISSVLYADRCIISRNVVESISYRYGSDLRGILMQLNFWSL 597

  Fly   678 LS-------AKEDASQKSGQQVATKDLKLGPWEVVRKVFTADE----HKHMSFADKSDLFFHDYS 731
            ::       .|:|.|.:...:........|......::.|:::    :......|...||.
pombe   598 VNFPSLPSKDKQDDSHEPFIEATISAFDEGVGVYNPRIQTSEDLLQTYSEEQMGDIGLLFM---- 658

  Fly   732 LAPLFVQQNYLQV-LPQG---NKKDVLAKVAAT---ADALSLGDLVEKRIRAN----SAWSLLPT 785
              |..|  |:.:| :|:.   .|:.::.|:..:   ||:||   .|:.|..:.    ..:.|:..
pombe   659 --PNLV--NWRKVCVPKSEMEEKEAIMEKLIYSHQYADSLS---YVDYRFSSQPTIYETYELMND 716

  Fly   786 QAFFSSV-LPGEHMCGHFTGQINFPGWLGKNSKSGKRARLAQELHDHTRVCTSGSRLSVRLDYAP 849
            .|.|..: |.....|.: ..|.|..|:  ....:...|....|.|:            ::|.|..
pombe   717 SASFEDMSLECRDNCAN-AFQDNLVGF--PTISNPFHANAPPEPHE------------LKLQYHS 766

  Fly   850 FLL----------------DNIVRPLAKDGQEGVPAALDVMKDYHLLREDLDSLVELTSWPGKK- 897
            |..                |:|| |.|.:.:|...:||.....|.|..:|:.:::...|:...:
pombe   767 FCFINNLFSKSSLKAISSNDSIV-PKALNNRELQLSALASTIGYKLDPDDVYNILSFLSFANSQV 830

  Fly   898 ---SPLDAVD 904
               :|.:::|
pombe   831 TSYTPPNSID 840

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gnf1	NP_001014605.1	COG5275	<151..358	CDD:227600	43/229 (19%)
		BRCT	232..309	CDD:278934	10/76 (13%)
		PRK04195	421..969	CDD:235250	108/568 (19%)
		AAA	506..633	CDD:278434	34/134 (25%)
		RFC1	764..917	CDD:285691	32/166 (19%)
elg1	NP_595265.1	P-loop_NTPase	428..538	CDD:304359	32/123 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5275
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23389
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.000