DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gnf1 and rfc1

DIOPT Version :9

Sequence 1:	NP_001014605.1	Gene:	Gnf1 / 40607	FlyBaseID:	FBgn0004913	Length:	1008	Species:	Drosophila melanogaster
Sequence 2:	NP_596607.1	Gene:	rfc1 / 2540426	PomBaseID:	SPBC23E6.07c	Length:	934	Species:	Schizosaccharomyces pombe

Alignment Length:	1090	Identity:	332/1090 - (30%)
Similarity:	498/1090 - (45%)	Gaps:	251/1090 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 IDSFFKRLPAKAKSAEAENGETPSKAPKR---RKAVIISSDEDEVV--SPPETKKRKASKTASSE 64
            |.|||....|:.|...:....:|.  |||   :|.:::|.|||..:  |.....|.|..|...||
pombe     6 IRSFFGGGNAQKKPKVSPTPTSPK--PKRSLKKKRIVLSDDEDGTIENSKVPASKSKVQKRNESE 68

  Fly    65 D------------------DVVAATPEPI--AKKARNGQKPALSKLKRHVDPTELFGGETKRVIV 109
            |                  |.|:.||:..  .:..|:..||.:...|...         |.:.:|
pombe    69 DISHSLPSIVHEDDKLVGSDGVSTTPDEYFEQQSTRSRSKPRIISNKETT---------TSKDVV 124

  Fly   110 PKPKTKAVLEFENEDIDRSLMEVDLDESIKEAAPEKKVHSITRSSPSPKRAKNSSPEPPKPKSTK 174
            ...||:   .|.|          |||.:    :..|.|...||::..|.:.|.......|.||..
pombe   125 HPVKTE---NFAN----------DLDTT----SDSKPVVHQTRATRKPAQPKAEKSTTSKSKSHT 172

  Fly   175 SKATT-----------PRVK-------KEKPAADLESSVLTDEERHERKRASAVLYQKYKNRSSC 221
            :.|||           ||..       |..|..|::|..:         .|....|::   .::.
pombe   173 TTATTHTSRSSKSKGLPRFSDEVSQALKNVPLIDVDSMGV---------MAPGTFYER---AATT 225

  Fly   222 LNPGSKEIPKGSPDCLSGLTFVVTGVLESMEREEAESVIKEYGGKVMTVVGKKLKYLVVGEEAGP 286
            ..||||.:|:|:.|||||::||:||:||::.|:||..:||:|||||......:..::::||.|||
pombe   226 QTPGSKPVPEGNSDCLSGISFVITGILETLTRQEATDLIKQYGGKVTGAPSVRTDFILLGENAGP 290

  Fly   287 KKLAVAEELNIPILSEDGLFDLIRE-----KSGIAKQVKEEKKSPKKEHSSEEKGKKEVKTSRRS 346
            :|:...::..||.::|||||.||..     .:|.|.|..::||        |::.||.::|..|.
pombe   291 RKVETIKQHKIPAINEDGLFYLITHLPASGGTGAAAQAAQQKK--------EQEEKKILETVARM 347

  Fly   347 SDKKEKEATKLKYGEKHDIAKHKVKEEHTSPKETKDKLNDVPAVTLKVKKEPSSQKEHPPSPRTA 411
            .|                                                  |::||..||
pombe   348 DD--------------------------------------------------SNKKESQPS---- 358

  Fly   412 DLKTLDVVGMAWVDKHKPTSIKEIVGQAGAASNVTNHNLKLKAKQERVKVLHYFNFPRLMNWLSK 476
                     ..|..|:.|||:|:|.|..|...                         :|..||..
pombe   359 ---------QIWTSKYAPTSLKDICGNKGVVQ-------------------------KLQKWLQD 389

  Fly   477 WYVNHDGNKKPQRPNPWAKNDDG-SFYKAALLSGPPGIGKTTTATLVVKELGFDAVEFNASDTRS 540
            ::.|...|.  .:|.|     || ..|||.||||||||||||.|.||.|..|:|.:|.|||||||
pombe   390 YHKNRKSNF--NKPGP-----DGLGLYKAVLLSGPPGIGKTTAAHLVAKLEGYDVLELNASDTRS 447

  Fly   541 KRLLKDEVSTLLSNKSLSGYFTGQGQAV---SRKHVLIMDEVDGMAGNEDRGGMQELIALIKDSS 602
            ||||.:::..:..::||:|||..:...|   ..:.||||||:|||:.. ||||:.:|..:||.|.
pombe   448 KRLLDEQLFGVTDSQSLAGYFGTKANPVDMAKSRLVLIMDEIDGMSSG-DRGGVGQLNMIIKKSM 511

  Fly   603 IPIICMCNDRNHPKIRSLVNYCYDLRFQRPRLEQIKGKIMSICFKEKVKISPAKVEEIIAATNND 667
            |||||:||||.|||:|.|....:||||:||....::.:||||.::|.:|:||..|::::..|.:|
pombe   512 IPIICICNDRAHPKLRPLDRTTFDLRFRRPDANSMRSRIMSIAYREGLKLSPQAVDQLVQGTQSD 576

  Fly   668 IRQSINHIAL--LSAKEDASQKSGQQV--ATKDLKLGPWEVVRKVFTADEHKHM-------SFAD 721
            :||.||.::.  ||..|...|.|...:  :.|.:.:.||::..:..    |..|       :..|
pombe   577 MRQIINLLSTYKLSCSEMTPQNSQAVIKNSEKHIVMKPWDICSRYL----HGGMFHPSSKSTIND 637

  Fly   722 KSDLFFHDYSLAPLFVQQNYLQVLPQGNKKDV--------LAKVAATADALSLGDLVEKRIRA-N 777
            |.:|:|:|:..:.|.||:|||...|...:::.        |..:::.|::.|..|||:..|.. .
pombe   638 KLELYFNDHEFSYLMVQENYLNTTPDRIRQEPPKMSHLKHLELISSAANSFSDSDLVDSMIHGPQ 702

  Fly   778 SAWSLLPTQAFFSSVLPGEHMCGHFTGQINFPGWLGKNSKSGKRARLAQELHDHTRVCTSGSRLS 842
            ..|||:||.|..|.|.|...:.|..:.||.|..|||.|||:.|..|:.:|:..|.|:..|.::|.
pombe   703 QHWSLMPTHALMSCVRPASFVAGSGSRQIRFTNWLGNNSKTNKLYRMLREIQVHMRLKVSANKLD 767

  Fly   843 VRLDYAPFLLDNIVRPLAKDGQEGVPAALDVMKDYHLLREDLDSLVELTSWPGKKSPLDA----- 902
            :|..|.|.|.:::...|:....:.||..:::|.:|:|.|||.||:.||.      .|.||
pombe   768 LRQHYIPILYESLPVKLSTGHSDVVPEIIELMDEYYLNREDFDSITELV------LPADAGEKLM 826

  Fly   903 --VDGRVKAALTRSYN-----------KEVMAYSYSAQAGIKKKKSEAAGADDDYLDEGPGEEDG 954
              :....|:|.||.||           .:|:....|||..:...: :|..|:|:.|:|....|
pombe   827 KTIPTAAKSAFTRKYNSSSHPIAFFGSSDVLPMKGSAQREVPDVE-DAIEAEDEMLEEASDSE-- 888

  Fly   955 AGGHLSSEEDEDKDNLELDSLIKAKKRTTTSKASGGSKKATSSTASKSKA 1004
                .::|||.|....:..|:.|..|:.|.:||...|..:||..:.|..|
pombe   889 ----AANEEDIDLSKDKFISVPKKPKKRTKAKAEASSSSSTSRRSRKKTA 934

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gnf1	NP_001014605.1	COG5275	<151..358	CDD:227600	71/229 (31%)
		BRCT	232..309	CDD:278934	35/76 (46%)
		PRK04195	421..969	CDD:235250	204/589 (35%)
		AAA	506..633	CDD:278434	72/129 (56%)
		RFC1	764..917	CDD:285691	57/171 (33%)
rfc1	NP_596607.1	COG5275	78..360	CDD:227600	95/390 (24%)
		BRCT	243..313	CDD:237994	30/69 (43%)
		AAA	409..539	CDD:99707	73/130 (56%)
		AAA	412..542	CDD:214640	72/130 (55%)
		HolB	506..>590	CDD:223546	38/83 (46%)
		SAGA-Tad1	<541..581	CDD:289533	14/39 (36%)
		RFC1	689..843	CDD:285691	56/159 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	114	1.000	Domainoid score	I1545
eggNOG	1	0.900	-	-		E1_COG5275
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2187
Inparanoid	1	1.050	428	1.000	Inparanoid score	I330
OMA	1	1.010	-	-		QHG52880
OrthoFinder	1	1.000	-	-		FOG0003699
OrthoInspector	1	1.000	-	-		oto102066
orthoMCL	1	0.900	-	-		OOG6_101059
Panther	1	1.100	-	-	LDO	PTHR23389
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1087
SonicParanoid	1	1.000	-	-		X3601
TreeFam	1	0.960	-	-
	14	13.860