DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gnf1 and Atad5

DIOPT Version :9

Sequence 1:	NP_001014605.1	Gene:	Gnf1 / 40607	FlyBaseID:	FBgn0004913	Length:	1008	Species:	Drosophila melanogaster
Sequence 2:	NP_001025027.1	Gene:	Atad5 / 237877	MGIID:	2442925	Length:	1826	Species:	Mus musculus

Alignment Length:	1208	Identity:	237/1208 - (19%)
Similarity:	412/1208 - (34%)	Gaps:	411/1208 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 PAKAKSAEAENGETPSKAPKRRKAVIISSDEDEV-------VSPPETKKRKASKTASSEDDVVAA 70
            |..|:::|..|..|       .:.:|:|||.:..       :|.|:..|:.:.|:.::|:::.:
Mouse   617 PKSARTSEKHNLYT-------AELIIVSSDSESPIRMKFTRISTPKKSKKSSKKSETTEEELTS- 673

  Fly    71 TPEPIAKKARNGQKPALSKLKRHVDPTELF---GGETKRVIVP-----KPKTKAVLEFENEDIDR 127
                 .||..|.....:||.|..::..:.|   |.:|:..:||     :.:.::..| ::.:||.
Mouse   674 -----QKKKANSTSKNISKAKELIEEAKAFQIGGSKTEETVVPLRRSSRHQARSAKE-KSPEIDD 732

  Fly   128 SLMEVDLD-ESIKEAAPEKKVHSITRSSPSPKRAKNSSPEPPKPKSTKSKATTPRVKKEKPAADL 191
            |::.:|.. .||:|  |||          |.|:.:|.:....| |..||....|...|..|....
Mouse   733 SVIVIDSSPTSIRE--PEK----------SQKKLQNLNDVLGK-KLNKSSKNVPGKMKIAPLFLA 784

  Fly   192 ESSVLTDEERHERKRASAVLYQKYKNRSSCLNPGSKEIPKGSPDC----LSGLTFVVTGVLESME 252
            :.:          |||:..::.        |:..|::..:.:.||    .:...|:::|:.:.::
Mouse   785 KRT----------KRAAIPVFD--------LDESSQDSSEQTQDCDVQFKAKRDFLMSGLPDLLK 831

  Fly   253 REEAE--SVIKEYGG------KVMTVVGKKLKYLV--VGEEAGPKKLAVAEELNIPI--LSE--- 302
            |:.|:  :.:..|..      :|:.|..|..:|.:  :...:.| .|...:|||..:  |||
Mouse   832 RQIAKKAAALDVYNAVSTSFQRVVHVQQKDDEYWLWHLKPPSCP-LLTEFKELNTKVTDLSEYVV 895

  Fly   303 -DGLFD-------------LIREKSGIAKQVK----EEKKSPKKEHSSEE--------------- 334
             .|.|.             ::|.:....|:|:    ||.|....|.|.|:
Mouse   896 AFGEFSTLNPNPRSNPAAVMMRTRKDFTKEVRNLLLEEIKCSNPEFSLEKYFPLLLKKRIEHQVL 960

  Fly   335 -KGKKEVKTSRRSSDKKEKEATKLKYGEKHDIAKHKVKEEHT-SPKETKDKLNDVPAVTLKVKKE 397
             :|..:..:.:...|..:||..:.:....:..:|.|.:.|:: ||:|.|.:..|:.      ::.
Mouse   961 CEGHGKQASPQLQPDVSQKETKRKQVATGNQKSKRKRQNEYSVSPEEMKGRSKDLD------ERI 1019

  Fly   398 PSSQKEHPPSPRTADLKTLDVVGMAWVDKHKPTSIKEIVGQAGAASNVTNHNLKLKAKQERVKVL 462
            .||.....||   .|..|.|   |.|.:|::|.:..|::|...|                 ||.|
Mouse  1020 SSSCTNLDPS---RDSGTED---MLWTEKYQPQNSNELIGNELA-----------------VKKL 1061

  Fly   463 HYFNFPRLMNWLSKWYVNHDGNKK----PQRPNPWAKND----------DGSFYKAA-------- 505
            |        :||..|       |:    .:|.|...|.|          |.:.:|.:
Mouse  1062 H--------SWLKDW-------KRRAELEERHNLKGKRDEKEEGILDLSDSTDFKGSSDDEENRL 1111

  Fly   506 ----LLSGPPGIGKTTTATLVVKELGFDAVEFNASDTRSKRLLKDEV------------------ 548
                |::||.|:|||.......:||||...|.|||..||.|.:..::
Mouse  1112 CNTVLITGPTGVGKTAAVYACAQELGFKIFEVNASSQRSGRQILSQLKEATQSHQVDKQGVNSQK 1176

  Fly   549 ---------------------------------------STLLSNKSLSGYF------------- 561
                                                   ...|..|:|:.||
Mouse  1177 PCFFNNYNIGKSPKKLNSPGKVVTSPRKLPPSSPKTSGQKRALLPKTLANYFKVSSKSKSNDDVG 1241

  Fly   562 -------------TGQGQAVSRK-------HV----------------LIMDEVDGMAGNEDRGG 590
                         ..|.|.:..|       |:                ::.:||| :..:||.|.
Mouse  1242 ALMGDDKGVKNSSLEQRQLIQTKSTNANNSHIKDVGAEESNRKKATSLILFEEVD-VIFDEDAGF 1305

  Fly   591 MQELIALIKDSSIPIICMCNDRNHPKIRSLVNYCY-DLRFQRPRLEQIKGKIMSICFKEKVKISP 654
            :..:...:..:..|:|...:|   |....:.:.|: ::.|..|.|..:...:..||..|..:...
Mouse  1306 LNAVKTFMATTKRPVILTTSD---PTFSLVFDGCFEEINFSIPSLLNVASYLQVICLVENFRTDF 1367

  Fly   655 AKVEEIIAATNNDIRQSINHIAL------------------------LSAKEDAS-------QKS 688
            .....::.|...|||:||.::..                        |...||.|       :..
Mouse  1368 KDFVTLLTANACDIRKSILYLQFWIRSGGGILEERPLSHCRENSRNTLVCSEDGSDANINSKKPK 1432

  Fly   689 GQQVATKDLKLGPWEVVRKVFTADEHKHMSFADKSDLFFHDYSLAPLFVQQNYLQVLPQGNKKDV 753
            ..:||......|..|.:..:      |:::...:..|....:.:......|..:|||.:.:.:::
Mouse  1433 RNRVALPRCDTGCAEALFGL------KNIASPSQDLLSLLKHKITTKEEWQKLIQVLTEFHVQNI 1491

  Fly   754 LAKVAATADALSLGDLVEKRIRANSAWSLLPTQAFFSSVLPGEHMCGHFTGQINFP--------- 809
                          ||:...:..     :||        || .|:.....|...||
Mouse  1492 --------------DLLHSNLEV-----ILP--------LP-VHVVPDVRGAYGFPVTTQASAPA 1528

  Fly   810 --GWLGKNSKSGKRARLAQELHDHTRVCTSGSRL-SVRLDY---------APFLL--DNIVR--- 857
              |.|.:.....:..|.:|:......|....|.| ...||:         ||.|.  |||.|
Mouse  1529 SMGHLTRKQSKDQPLRKSQKRKQKKMVILDDSDLFDTGLDFSGELPSLSPAPSLSVEDNIRRDSN 1593

  Fly   858 PLAKDGQEGV--------PAALDVMKDYHLLREDLDSLVE----------LTSWPGKKSPLDA-- 902
            |..|....|.        |..|...|...|:...|:||.|          |.:.||:::.|..
Mouse  1594 PEIKTQNSGFKPHSVPQPPKTLAEKKCCMLVSHCLNSLSEFMENMSFIDALLTDPGEQNELGRSA 1658

  Fly   903 ---VDGRVKAALTRSYNKEVMAYSYSAQAGIKKKKSEA 937
               .:||||:.|...::.|.........||..|..:||
Mouse  1659 FHWTNGRVKSGLCDEFSLENRDRWAPQSAGELKATAEA 1696

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gnf1	NP_001014605.1	COG5275	<151..358	CDD:227600	49/259 (19%)
		BRCT	232..309	CDD:278934	21/109 (19%)
		PRK04195	421..969	CDD:235250	137/730 (19%)
		AAA	506..633	CDD:278434	39/233 (17%)
		RFC1	764..917	CDD:285691	46/201 (23%)
Atad5	NP_001025027.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	170..254
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	282..311
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	323..367
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	398..572
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	588..623		2/5 (40%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	647..684		8/42 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	709..729		3/20 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	965..1034		16/77 (21%)
		P-loop_NTPase	1115..>1160	CDD:304359	18/44 (41%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1183..1216		0/32 (0%)
		LXCXE motif	1415..1419		1/3 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1527..1552		4/24 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1592..1611		3/18 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5275
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900