Protein Alignment opa and ZIC4

DIOPT Version :10

• Sequence 1: NP_001368991.1
• Gene: opa / 40605
• FlyBaseID: FBgn0003002
• Length: 688
• Species: Drosophila melanogaster
• Sequence 2: NP_001161850.1
• Gene: ZIC4 / 84107
• HGNCID: 20393
• Length: 384
• Species: Homo sapiens
• Alignment Length: 349
• Identity: 174/349 - (49%)
• Similarity: 212/349 - (60%)
• Gaps: 60/349 - (17%)

  Fly    99 AGSAG----QASAAADSMLFSGF---PAQAAELGSGFGQHPFHSHHHHHQMRMGM-ADAYAAGHP 155
            :.|:|    |.:||:...:|.|.   |.||:.      ..|.:.     .:|:|: .|.||...|
Human    74 SSSSGHHGPQLTAASSPSVFPGLHEEPPQASP------SRPLNG-----LLRLGLPGDMYARPEP 127

  Fly   156 YNHHGNFPTAAVHHPVVHHPSHHAMSAMH-------------PAGAGAFLRYMRHQPASSASSVK 207
                  ||..    |.....:..|.:|:|             |.|.|||.|||| ||      :|
Human   128 ------FPPG----PAARSDALAAAAALHGYGGMNLTVNLAAPHGPGAFFRYMR-QP------IK 175

  Fly   208 QEMQCLWIDPDQPGLVPPGGRKTCNKVFHSMHEIVTHLTVEHVGGPECTTHACFWVGCSRNGRPF 272
            ||:.|.|:..|  |...|   ..|:|.|.:|||:|||:|||||||||...|.|||..|.|.|:||
Human   176 QELICKWLAAD--GTATP---SLCSKTFSTMHELVTHVTVEHVGGPEQANHICFWEECPRQGKPF 235

  Fly   273 KAKYKLVNHIRVHTGEKPFACPHPGCGKVFARSENLKIHKRTHTGEKPFKCEHEGCDRRFANSSD 337
            |||||||||||||||||||.||.||||||||||||||||||||||||||:||.|||:||||||||
Human   236 KAKYKLVNHIRVHTGEKPFPCPFPGCGKVFARSENLKIHKRTHTGEKPFRCEFEGCERRFANSSD 300

  Fly   338 RKKHSHVHTSDKPYNCRINGCDKSYTHPSSLRKHMKVHGNVDEKSPSHGYDSEGEESSSSSIITG 402
            ||||||||||||||.|::.||||.|||||||||||||||.  ...||.||||    ::.|::::.
Human   301 RKKHSHVHTSDKPYTCKVRGCDKCYTHPSSLRKHMKVHGR--SPPPSSGYDS----ATPSALVSP 359

  Fly   403 GAQTPPSTRLDGSAGSSSGVSSLS 426
            .:.....:::..||..::..:.||
Human   360 SSDCGHKSQVASSAAVAARTADLS 383

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
opa	NP_001368991.1	zf_ZIC	206..253	CDD:436441	23/46 (50%)
		C2H2 Zn finger	265..285	CDD:275368	16/19 (84%)
		SFP1	<287..373	CDD:227516	75/85 (88%)
		C2H2 Zn finger	293..315	CDD:275368	20/21 (95%)
		C2H2 Zn finger	323..345	CDD:275368	19/21 (90%)
		C2H2 Zn finger	353..375	CDD:275368	17/21 (81%)
ZIC4	NP_001161850.1	zf_ZIC	172..216	CDD:436441	25/54 (46%)
		COG5048	<192..338	CDD:227381	118/145 (81%)
		C2H2 Zn finger	228..248	CDD:275368	16/19 (84%)
		C2H2 Zn finger	256..278	CDD:275368	20/21 (95%)
		C2H2 Zn finger	286..308	CDD:275368	19/21 (90%)
		C2H2 Zn finger	316..338	CDD:275368	17/21 (81%)