Protein Alignment opa and Glis2

DIOPT Version :10

• Sequence 1: NP_001368991.1
• Gene: opa / 40605
• FlyBaseID: FBgn0003002
• Length: 688
• Species: Drosophila melanogaster
• Sequence 2: XP_036016078.1
• Gene: Glis2 / 83396
• MGIID: 1932535
• Length: 548
• Species: Mus musculus
• Alignment Length: 427
• Identity: 136/427 - (31%)
• Similarity: 190/427 - (44%)
• Gaps: 90/427 - (21%)

  Fly   163 PTAAVHHPVVH---HPSHHAMSAMHPAGAGAFLRYMRHQPASS------------ASSVKQEMQC 212
            |||....|:.:   .||  :.....|.|:|..|    |.||||            ...:.:::.|
Mouse   139 PTAVDFQPLRYLDGVPS--SFQFFLPLGSGGAL----HLPASSFLPPPKDKCLSPELPLAKQLVC 197

  Fly   213 LWIDPDQPGLVPPGGRKTCNKVFHSMHEIVTHLTVEHVGGPECTTHACFWVGCSRNGRPFKAKYK 277
            .|              ..||::|..:.::|.|:...||...:...:.|.|.||:|:||.|.|:||
Mouse   198 RW--------------AKCNQLFELLQDLVDHVNDHHVKPEQDARYCCHWEGCARHGRGFNARYK 248

  Fly   278 LVNHIRVHTGEKPFACPHPGCGKVFARSENLKIHKRTHTGEKPFKCEHEGCDRRFANSSDRKKHS 342
            ::.|||.||.|||..|  |.|.|.|:|.||||||.|:||||||:.|.:|||::|::|||||.||:
Mouse   249 MLIHIRTHTNEKPHRC--PTCNKSFSRLENLKIHNRSHTGEKPYVCPYEGCNKRYSNSSDRFKHT 311

  Fly   343 HVHTSDKPYNCRINGCDKSYTHPSSLRKHMKVHGNV-------------DEKSPSHGYDSEGEES 394
            ..|..||||.|::.||.|.||.|||||||:|.||:.             ..|.|....||....|
Mouse   312 RTHYVDKPYYCKMPGCHKRYTDPSSLRKHIKAHGHFVSHEQQELLQLRPPPKPPLPTPDSGSYVS 376

  Fly   395 SSSSIIT------GGAQTP------PSTRLDGSA-------GSSSGVSSLSGGSGIKSSPHSIKS 440
            .:..||.      ||...|      |...||.||       |...|:     |.|:..|...:..
Mouse   377 GAQIIIPNPAALFGGPSLPGLPLPLPPGPLDLSALACGNGGGGGGGI-----GPGLPGSVLPLNL 436

  Fly   441 EPNPMHSVHLGASSSGSS--STASSSASHLLQHQQHQHQQQQQ---QQQHQQQAQQQQQLTAHPS 500
            ..||:.....||...|..  |....||....:.::.:.....:   .:.|:...::.::..:.||
Mouse   437 AKNPLLPSPFGAGGLGLPVVSLLGGSAGSKAEGEKGRGSVPARVLGLEDHKTPLERTERSRSRPS 501

  Fly   501 DPKSSP-----ALQLMAASASAYLPPPLGP-----PP 527
             |...|     .|.|...:::|..|..|.|     ||
Mouse   502 -PDGLPLLPGTVLDLSTGNSAASSPEVLTPGWVVIPP 537

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
opa	NP_001368991.1	zf_ZIC	206..253	CDD:436441	9/46 (20%)
		C2H2 Zn finger	265..285	CDD:275368	11/19 (58%)
		SFP1	<287..373	CDD:227516	52/85 (61%)
		C2H2 Zn finger	293..315	CDD:275368	13/21 (62%)
		C2H2 Zn finger	323..345	CDD:275368	12/21 (57%)
		C2H2 Zn finger	353..375	CDD:275368	14/21 (67%)
Glis2	XP_036016078.1	C2H2 Zn finger	240..256	CDD:275368	9/15 (60%)
		COG5048	260..>354	CDD:227381	54/95 (57%)
		C2H2 Zn finger	264..284	CDD:275368	13/21 (62%)
		C2H2 Zn finger	292..314	CDD:275368	12/21 (57%)
		C2H2 Zn finger	322..344	CDD:275368	14/21 (67%)