DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment opa and Zxdc

DIOPT Version :9

Sequence 1:	NP_001368991.1	Gene:	opa / 40605	FlyBaseID:	FBgn0003002	Length:	688	Species:	Drosophila melanogaster
Sequence 2:	NP_766590.1	Gene:	Zxdc / 80292	MGIID:	1933108	Length:	858	Species:	Mus musculus

Alignment Length:	502	Identity:	119/502 - (23%)
Similarity:	180/502 - (35%)	Gaps:	130/502 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 QQQQQQQQQQQQQDQESAAATAAAYQNSGYGHFNSYASRDFLLGRREAEYGVAGSAGQASAAADS 111
            |::.:........:|..|||..||...:...|     ::|.|:......:.:|.:...|:.:...
Mouse    89 QEEAEPDSGASPTEQVPAAAPGAALAGTVTIH-----NQDLLVRFDRGVFTLAAAPAPAAPSLHP 148

  Fly   112 MLFSGF-PAQAAELGSGFGQHPFHSHHHHHQMRMGMADAYAAGHPYNHHGNFPTAAV-----HHP 170
            ....|. |:.||                  ..|.|.. |.:||.| .:....|..|:     |..
Mouse   149 ATTPGLEPSSAA------------------ASRRGPV-AASAGSP-AYRCPEPQCALSFAKKHQL 193

  Fly   171 VVHHPSHHAMSAMHP-----AGAG-AFLRYMRHQPASSASSVKQEMQCLWIDPDQPGLVPPGGRK 229
            .||..:|.::....|     .|.| ||         :::..:|:.:|.  .|..:|...|.||
Mouse   194 KVHLLTHGSLQGRRPFKCPLDGCGWAF---------TTSYKLKRHLQS--HDKLRPFSCPVGG-- 245

  Fly   230 TCNKVFHSMHEIVTHLTVE--------HVGGPECTTHA-----------------CFWVGCSRNG 269
             |.|.|.:::.:..|:...        .|......|||                 |.:.||.:.
Mouse   246 -CGKKFTTVYNLKAHMKGHEQESLFKCEVCAERFPTHAKLNSHQRSHFEPERPYKCDFPGCEKT- 308

  Fly   270 RPFKAKYKLVNHIRVHTGEKP-FACPHPGCGKVFARSENLKIHKRTHTGEKPFKCEHEGCDRRFA 333
              |.....|.:|.|.|..|:. |:|..|||.|.:.::..||||.|:||||:||.|:.:.|...|.
Mouse   309 --FITVSALFSHNRAHFREQELFSCSFPGCNKQYDKACRLKIHLRSHTGERPFICDSDSCGWTFT 371

  Fly   334 NSSDRKKHSHVHTSDKPYNCRINGCDKSYTHPSSLRKHMKVHGNVDEKSPSHGYDSEGEESSSSS 398
            :.|...:|...|..|:.:.|.:.||.||:|.    .:|:|.|.
Mouse   372 SMSKLLRHKRKHDDDRRFTCPVEGCGKSFTR----AEHLKGHS---------------------- 410

  Fly   399 IITGGAQTPPSTRLDGSAGSSSGVSSLSGGSGIKSSPHSIKSEPNPMHSVHLGASSSGSSSTASS 463
             ||.....|....::|.....|..|||        ..||.|         ||....:..|....|
Mouse   411 -ITHLGTKPFECPVEGCCARFSARSSL--------YIHSKK---------HLQDVGTPKSRCPVS 457

  Fly   464 SASHLL--QHQQHQH--QQQQQQQQHQQQAQQQQQLTAHPSDPKSSP 506
            |.:.|.  :|....|  :|..::|....|.:....||  ||...|||
Mouse   458 SCNRLFTSKHSMKAHVVRQHSRRQDLVPQLEAPSSLT--PSSELSSP 502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
opa	NP_001368991.1	zf_ZIC	206..253	CDD:408166	12/54 (22%)
		C2H2 Zn finger	265..285	CDD:275368	5/19 (26%)
		SFP1	<287..373	CDD:227516	32/86 (37%)
		C2H2 Zn finger	293..315	CDD:275368	10/21 (48%)
		C2H2 Zn finger	323..345	CDD:275368	5/21 (24%)
		C2H2 Zn finger	353..375	CDD:275368	8/21 (38%)
Zxdc	NP_766590.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..73
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	85..108		3/18 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	142..175		11/52 (21%)
		C2H2 Zn finger	178..200	CDD:275368	5/21 (24%)
		zf-C2H2_aberr	209..354	CDD:293622	39/161 (24%)
		C2H2 Zn finger	211..233	CDD:275368	6/32 (19%)
		zf-H2C2_2	226..252	CDD:290200	10/30 (33%)
		C2H2 Zn finger	241..263	CDD:275368	7/24 (29%)
		C2H2 Zn finger	271..291	CDD:275368	4/19 (21%)
		C2H2 Zn finger	300..322	CDD:275368	7/24 (29%)
		C2H2 Zn finger	334..353	CDD:275368	9/18 (50%)
		C2H2 Zn finger	361..383	CDD:275368	5/21 (24%)
		zf-H2C2_2	376..402	CDD:290200	8/25 (32%)
		C2H2 Zn finger	391..413	CDD:275368	10/48 (21%)
		COG5048	392..>691	CDD:227381	37/157 (24%)
		C2H2 Zn finger	421..443	CDD:275368	8/38 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	624..652
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	671..714
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	727..751
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167847745
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930