DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment opa and ZXDC

DIOPT Version :9

Sequence 1:	NP_001368991.1	Gene:	opa / 40605	FlyBaseID:	FBgn0003002	Length:	688	Species:	Drosophila melanogaster
Sequence 2:	NP_079388.3	Gene:	ZXDC / 79364	HGNCID:	28160	Length:	858	Species:	Homo sapiens

Alignment Length:	748	Identity:	162/748 - (21%)
Similarity:	220/748 - (29%)	Gaps:	265/748 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    81 SYASRDFLLGRREAEYGVAGSAGQASAAADSMLFSGFPAQAAELGSGF-----GQHPFHSHHHHH 140
            |.|.|..||.|...:.|.....|:||..:..      ||:....|..|     ..|
Human    34 SPARRRLLLVRGPEDGGPGARPGEASGPSPP------PAEDDSDGDSFLVLLEVPH--------- 83

  Fly   141 QMRMGMADAYAAGHPYNHHG---NFPTAAVHHPVVHHPSHHAMSAMHPAGA-------------- 188
                |.|.|.|||......|   |..:.....|  ..|:......:.||||
Human    84 ----GGAAAEAAGSQEAEPGSRVNLASRPEQGP--SGPAAPPGPGVAPAGAVTISSQDLLVRLDR 142

  Fly   189 GAFLRYMRHQPASSASSVKQEMQCLWIDPDQPGLVPPGGR---KTCNKVFHSMHEIVTHLTVEHV 250
            |.........||::.::..:..      |...|...||.|   ..|...|...|::..|| :.|.
Human   143 GVLALSAPPGPATAGAAAPRRA------PQASGPSTPGYRCPEPQCALAFAKKHQLKVHL-LTHG 200

  Fly   251 GGP-----ECTTHACFWVGCSRNGRPFKAKYKLVNHIRVHTGEKPFACPHPGCGKVFARSENLKI 310
            ||.     :|....|.|.        |...|||..|::.|...:||.||..||||.|....|||.
Human   201 GGQGRRPFKCPLEGCGWA--------FTTSYKLKRHLQSHDKLRPFGCPVGGCGKKFTTVYNLKA 257

  Fly   311 HKRTHTGEKPFKCEHEGCDRRFANSSDRKKHSHVH-TSDKPYNCRINGCDKSYTHPSSLRKHMKV 374
            |.:.|..|..|||  |.|..||...:....|...| ..::||.|...||:|::...|:|..|.:.
Human   258 HMKGHEQESLFKC--EVCAERFPTHAKLSSHQRSHFEPERPYKCDFPGCEKTFITVSALFSHNRA 320

  Fly   375 HGNVDE------KSPSHGYDS-----------EGEE-------------SSSSSIITGGAQTPPS 409
            |....|      ...|..||.           .||.             :|.|.::....:....
Human   321 HFREQELFSCSFPGCSKQYDKACRLKIHLRSHTGERPFICDSDSCGWTFTSMSKLLRHRRKHDDD 385

  Fly   410 TR----LDGSAGSSSGVSSLSGGSGIKSSPHSIKSEPNPMHSVHLG------------ASSSGSS 458
            .|    ::|...|.:....|.|        |||         .|||            |..|..|
Human   386 RRFTCPVEGCGKSFTRAEHLKG--------HSI---------THLGTKPFECPVEGCCARFSARS 433

  Fly   459 STASSSASHL--------------------LQHQQHQHQQQQQQQQHQQQAQQQQQLTAHPSDPK 503
            |....|..|:                    .:|....|..:|..::.....|.:...:..||...
Human   434 SLYIHSKKHVQDVGAPKSRCPVSTCNRLFTSKHSMKAHMVRQHSRRQDLLPQLEAPSSLTPSSEL 498

  Fly   504 SSPA------LQLMA--------ASASA-------------------------YLP---PPLGP- 525
            |||.      :.|.|        ||.||                         .||   ..|||
Human   499 SSPGQSELTNMDLAALFSDTPANASGSAGGSDEALNSGILTIDVTSVSSSLGGNLPANNSSLGPM 563

  Fly   526 -----------PPSHHHHPHHHQAAPSPGAAAASASMLHHN-----------------------H 556
                       |||          ..||.....:|::|...                       .
Human   564 EPLVLVAHSDIPPS----------LDSPLVLGTAATVLQQGSFSVDDVQTVSAGALGCLVALPMK 618

  Fly   557 HLLYHPAAQHHPPSDWYHTTAPSGSA---------EAMNPLNHFGHHHHHHHLMHPGA-----AT 607
            :|...|.|.....:...|.|.|:.|:         |.:.|:.           :.|.:     |.
Human   619 NLSDDPLALTSNSNLAAHITTPTSSSTPRENASVPELLAPIK-----------VEPDSPSRPGAV 672

  Fly   608 AYXEWENWWPEEA-PPPAAQPMATPTTIAGGTG 639
            .. |..:..|:.. |.||.|..|..|.::.|||
Human   673 GQQEGSHGLPQSTLPSPAEQHGAQDTELSAGTG 705

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
opa	NP_001368991.1	zf_ZIC	206..253	CDD:408166	12/49 (24%)
		C2H2 Zn finger	265..285	CDD:275368	5/19 (26%)
		SFP1	<287..373	CDD:227516	33/86 (38%)
		C2H2 Zn finger	293..315	CDD:275368	11/21 (52%)
		C2H2 Zn finger	323..345	CDD:275368	6/21 (29%)
		C2H2 Zn finger	353..375	CDD:275368	7/21 (33%)
ZXDC	NP_079388.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..127		26/113 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	151..174		4/28 (14%)
		C2H2 Zn finger	177..199	CDD:275368	5/22 (23%)
		zf-C2H2_aberr	208..353	CDD:293622	47/154 (31%)
		zf-C2H2	208..232	CDD:278523	8/31 (26%)
		C2H2 Zn finger	210..232	CDD:275368	8/29 (28%)
		C2H2 Zn finger	240..262	CDD:275368	11/21 (52%)
		C2H2 Zn finger	270..290	CDD:275368	6/21 (29%)
		COG5048	<284..443	CDD:227381	36/175 (21%)
		C2H2 Zn finger	299..321	CDD:275368	7/21 (33%)
		C2H2 Zn finger	333..352	CDD:275368	3/18 (17%)
		C2H2 Zn finger	360..382	CDD:275368	2/21 (10%)
		zf-H2C2_2	375..401	CDD:290200	3/25 (12%)
		C2H2 Zn finger	390..412	CDD:275368	7/38 (18%)
		COG5048	391..>584	CDD:227381	41/219 (19%)
		C2H2 Zn finger	420..442	CDD:275368	5/21 (24%)
		Required for transcriptional activation	579..688		17/119 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	660..696		8/46 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	726..756
		Interaction with CIITA	781..858
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	837..858
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157351
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930