DRSC/TRiP Functional Genomics Resources

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Protein Alignment opa and ZXDA

DIOPT Version :10

Sequence 1:NP_001368991.1 Gene:opa / 40605 FlyBaseID:FBgn0003002 Length:688 Species:Drosophila melanogaster
Sequence 2:NP_009087.1 Gene:ZXDA / 7789 HGNCID:13198 Length:799 Species:Homo sapiens


Alignment Length:715 Identity:156/715 - (21%)
Similarity:240/715 - (33%) Gaps:235/715 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly    63 SAAATAAAYQNSGYGHFNSYASRDFLLGRREAEYGV---------AGSAGQASAAADSMLF---S 115
            ||...|||:..:...|     ::|.||   ..|.||         |...|.|.|.....|.   :
Human   153 SAPGPAAAFAGTVTIH-----NQDLLL---RFENGVLTLATPPPHAWEPGAAPAQQPRCLIAPQA 209

  Fly   116 GFPAQAAELGSGFGQHPFHSHHHHHQMRM-----------------GMADAYAAGHPYNHHGNFP 163
            ||| |||        ||.........:.:                 |:|   ||..|....|:.|
Human   210 GFP-QAA--------HPGDCPELRSDLLLAEPAEPAPAPAPQEEAEGLA---AALGPRGLLGSGP 262

  Fly   164 --------------TAAVHHPV-VHHPSHHAMSAMHP-----AGAG-AFLRYMRHQPASSASSVK 207
                          |.|..|.: :|..:|.:.....|     .|.| .|         :::..:|
Human   263 GVVLYLCPEALCGQTFAKKHQLKMHLLTHSSSQGQRPFKCPLGGCGWTF---------TTSYKLK 318

  Fly   208 QEMQCLWIDPDQPGLVPPGGRKTCNKVFHSMHEIVTHL-------------------TVEHVGG- 252
            :.:|.  .|..:|...|..|   |.|.|.:::.:..|:                   |...:|. 
Human   319 RHLQS--HDKLRPFGCPAEG---CGKSFTTVYNLKAHMKGHEQENSFKCEVCEESFPTQAKLGAH 378

  Fly   253 ------PECTTHACFWVGCSRNGRPFKAKYKLVNHIRVHTGEKP-FACPHPGCGKVFARSENLKI 310
                  || ..:.|.:.||.:.   |.....|.:|.|.|..|:. |:|..|||.|.:.::..|||
Human   379 QRSHFEPE-RPYQCAFSGCKKT---FITVSALFSHNRAHFREQELFSCSFPGCSKQYDKACRLKI 439

  Fly   311 HKRTHTGEKPFKCEHEGCDRRFANSSDRKKHSHVHTSDKPYNCRINGCDKSYTHPSSLRKHMKVH 375
            |.|:||||:||.|:.:||...|.:.|...:|...|..|:.:.|.:.||.||:|....|:.|...|
Human   440 HLRSHTGERPFLCDFDGCGWNFTSMSKLLRHKRKHDDDRRFMCPVEGCGKSFTRAEHLKGHSITH 504

  Fly   376 -GNVDEKSPSHGYDSEGEESSS---------SSIITGGAQTPPSTRLDGSAGSSSGVSSLSGGSG 430
             |......|..|..:.....||         ..:.|..::.|                 :|..:.
Human   505 LGTKPFVCPVAGCCARFSARSSLYIHSKKHLQDVDTWKSRCP-----------------ISSCNK 552

  Fly   431 IKSSPHSIKSEPNPMHSVH---LGASSSGSSSTASSSASHLLQHQQHQHQQQQQQQQHQQQAQQQ 492
            :.:|.||:|:.....|.|.   |....:.:|.|.||..:                .|.|......
Human   553 LFTSKHSMKTHMVKRHKVGQDLLAQLEAANSLTPSSELT----------------SQRQNDLSDA 601

  Fly   493 QQLTAHPSDPKSSPA------------LQLMAASASAYLPPPLGPPPSHHHHPHHHQAAPSPGAA 545
            :.::.....|.|:.|            |.:..||.|:.|   .|..|:::::        |.|.|
Human   602 EIVSLFSDVPDSTSAALLDTALVNSGILTIDVASVSSTL---AGHLPANNNN--------SVGQA 655

  Fly   546 AASASMLHHNHHLLYHPAAQHHPP----SDWYHTTAPSG-----------SAEAMNPLNHFGHHH 595
            ....|::           |...||    :..:..||.:|           |:.::.||       
Human   656 VDPPSLM-----------ATSDPPQSLDTSLFFGTAATGFQQSSLNMDEVSSVSVGPL------- 702

  Fly   596 HHHHLMHPGAATAYXEWENWWPEEAPPPAAQPMATPTTIAGGTGPAQGSVEESASSL------DW 654
                    |:..:.  .:|..||   |.|..|.:..|.......|:....|.|.|.|      :|
Human   703 --------GSLDSLA-MKNSSPE---PQALTPSSKLTVDTDTLTPSSTLCENSVSELLTPAKAEW 755

  Fly   655  654
            Human   756  755

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
opaNP_001368991.1 zf_ZIC 206..253 CDD:436441 12/72 (17%)
C2H2 Zn finger 265..285 CDD:275368 5/19 (26%)
SFP1 <287..373 CDD:227516 34/86 (40%)
C2H2 Zn finger 293..315 CDD:275368 10/21 (48%)
C2H2 Zn finger 323..345 CDD:275368 6/21 (29%)
C2H2 Zn finger 353..375 CDD:275368 8/21 (38%)
ZXDANP_009087.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..89
Required for interaction with ZXDC. /evidence=ECO:0000269|PubMed:17493635 267..573 80/340 (24%)
C2H2 Zn finger 269..291 CDD:275368 4/21 (19%)
zf-C2H2 300..324 CDD:395048 5/34 (15%)
C2H2 Zn finger 302..324 CDD:275368 5/32 (16%)
C2H2 Zn finger 332..354 CDD:275368 6/24 (25%)
COG5048 <340..535 CDD:227381 54/198 (27%)
C2H2 Zn finger 362..382 CDD:275368 2/19 (11%)
C2H2 Zn finger 391..413 CDD:275368 7/24 (29%)
C2H2 Zn finger 425..444 CDD:275368 9/18 (50%)
C2H2 Zn finger 452..474 CDD:275368 6/21 (29%)
COG5048 462..>743 CDD:227381 67/354 (19%)
C2H2 Zn finger 482..504 CDD:275368 8/21 (38%)
C2H2 Zn finger 512..534 CDD:275370 4/21 (19%)
Required for transcriptional activation 572..699 28/164 (17%)
Blue background indicates that the domain is not in the aligned region.

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