DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment opa and ZXDA

DIOPT Version :9

Sequence 1:	NP_001368991.1	Gene:	opa / 40605	FlyBaseID:	FBgn0003002	Length:	688	Species:	Drosophila melanogaster
Sequence 2:	NP_009087.1	Gene:	ZXDA / 7789	HGNCID:	13198	Length:	799	Species:	Homo sapiens

Alignment Length:	715	Identity:	156/715 - (21%)
Similarity:	240/715 - (33%)	Gaps:	235/715 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 SAAATAAAYQNSGYGHFNSYASRDFLLGRREAEYGV---------AGSAGQASAAADSMLF---S 115
            ||...|||:..:...|     ::|.||   ..|.||         |...|.|.|.....|.   :
Human   153 SAPGPAAAFAGTVTIH-----NQDLLL---RFENGVLTLATPPPHAWEPGAAPAQQPRCLIAPQA 209

  Fly   116 GFPAQAAELGSGFGQHPFHSHHHHHQMRM-----------------GMADAYAAGHPYNHHGNFP 163
            ||| |||        ||.........:.:                 |:|   ||..|....|:.|
Human   210 GFP-QAA--------HPGDCPELRSDLLLAEPAEPAPAPAPQEEAEGLA---AALGPRGLLGSGP 262

  Fly   164 --------------TAAVHHPV-VHHPSHHAMSAMHP-----AGAG-AFLRYMRHQPASSASSVK 207
                          |.|..|.: :|..:|.:.....|     .|.| .|         :::..:|
Human   263 GVVLYLCPEALCGQTFAKKHQLKMHLLTHSSSQGQRPFKCPLGGCGWTF---------TTSYKLK 318

  Fly   208 QEMQCLWIDPDQPGLVPPGGRKTCNKVFHSMHEIVTHL-------------------TVEHVGG- 252
            :.:|.  .|..:|...|..|   |.|.|.:::.:..|:                   |...:|.
Human   319 RHLQS--HDKLRPFGCPAEG---CGKSFTTVYNLKAHMKGHEQENSFKCEVCEESFPTQAKLGAH 378

  Fly   253 ------PECTTHACFWVGCSRNGRPFKAKYKLVNHIRVHTGEKP-FACPHPGCGKVFARSENLKI 310
                  || ..:.|.:.||.:.   |.....|.:|.|.|..|:. |:|..|||.|.:.::..|||
Human   379 QRSHFEPE-RPYQCAFSGCKKT---FITVSALFSHNRAHFREQELFSCSFPGCSKQYDKACRLKI 439

  Fly   311 HKRTHTGEKPFKCEHEGCDRRFANSSDRKKHSHVHTSDKPYNCRINGCDKSYTHPSSLRKHMKVH 375
            |.|:||||:||.|:.:||...|.:.|...:|...|..|:.:.|.:.||.||:|....|:.|...|
Human   440 HLRSHTGERPFLCDFDGCGWNFTSMSKLLRHKRKHDDDRRFMCPVEGCGKSFTRAEHLKGHSITH 504

  Fly   376 -GNVDEKSPSHGYDSEGEESSS---------SSIITGGAQTPPSTRLDGSAGSSSGVSSLSGGSG 430
             |......|..|..:.....||         ..:.|..::.|                 :|..:.
Human   505 LGTKPFVCPVAGCCARFSARSSLYIHSKKHLQDVDTWKSRCP-----------------ISSCNK 552

  Fly   431 IKSSPHSIKSEPNPMHSVH---LGASSSGSSSTASSSASHLLQHQQHQHQQQQQQQQHQQQAQQQ 492
            :.:|.||:|:.....|.|.   |....:.:|.|.||..:                .|.|......
Human   553 LFTSKHSMKTHMVKRHKVGQDLLAQLEAANSLTPSSELT----------------SQRQNDLSDA 601

  Fly   493 QQLTAHPSDPKSSPA------------LQLMAASASAYLPPPLGPPPSHHHHPHHHQAAPSPGAA 545
            :.::.....|.|:.|            |.:..||.|:.|   .|..|:::::        |.|.|
Human   602 EIVSLFSDVPDSTSAALLDTALVNSGILTIDVASVSSTL---AGHLPANNNN--------SVGQA 655

  Fly   546 AASASMLHHNHHLLYHPAAQHHPP----SDWYHTTAPSG-----------SAEAMNPLNHFGHHH 595
            ....|::           |...||    :..:..||.:|           |:.::.||
Human   656 VDPPSLM-----------ATSDPPQSLDTSLFFGTAATGFQQSSLNMDEVSSVSVGPL------- 702

  Fly   596 HHHHLMHPGAATAYXEWENWWPEEAPPPAAQPMATPTTIAGGTGPAQGSVEESASSL------DW 654
                    |:..:.  .:|..||   |.|..|.:..|.......|:....|.|.|.|      :|
Human   703 --------GSLDSLA-MKNSSPE---PQALTPSSKLTVDTDTLTPSSTLCENSVSELLTPAKAEW 755

Fly 655 654
Human 756 755

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
opa	NP_001368991.1	zf_ZIC	206..253	CDD:408166	12/72 (17%)
		C2H2 Zn finger	265..285	CDD:275368	5/19 (26%)
		SFP1	<287..373	CDD:227516	34/86 (40%)
		C2H2 Zn finger	293..315	CDD:275368	10/21 (48%)
		C2H2 Zn finger	323..345	CDD:275368	6/21 (29%)
		C2H2 Zn finger	353..375	CDD:275368	8/21 (38%)
ZXDA	NP_009087.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..89
		Required for interaction with ZXDC. /evidence=ECO:0000269\|PubMed:17493635	267..573		80/340 (24%)
		C2H2 Zn finger	269..291	CDD:275368	4/21 (19%)
		zf-C2H2_aberr	300..445	CDD:293622	37/162 (23%)
		zf-C2H2	300..324	CDD:278523	5/34 (15%)
		C2H2 Zn finger	302..324	CDD:275368	5/32 (16%)
		C2H2 Zn finger	332..354	CDD:275368	6/24 (25%)
		zf-H2C2_2	346..369	CDD:290200	1/22 (5%)
		C2H2 Zn finger	362..382	CDD:275368	2/19 (11%)
		C2H2 Zn finger	391..413	CDD:275368	7/24 (29%)
		C2H2 Zn finger	425..444	CDD:275368	9/18 (50%)
		COG5048	<437..568	CDD:227381	40/147 (27%)
		C2H2 Zn finger	452..474	CDD:275368	6/21 (29%)
		zf-H2C2_2	467..493	CDD:290200	8/25 (32%)
		C2H2 Zn finger	482..504	CDD:275368	8/21 (38%)
		C2H2 Zn finger	512..534	CDD:275370	4/21 (19%)
		Required for transcriptional activation	572..699		28/164 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157350
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930