DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment opa and zic4

DIOPT Version :9

Sequence 1:	NP_001368991.1	Gene:	opa / 40605	FlyBaseID:	FBgn0003002	Length:	688	Species:	Drosophila melanogaster
Sequence 2:	XP_005162576.1	Gene:	zic4 / 767673	ZFINID:	ZDB-GENE-040622-4	Length:	494	Species:	Danio rerio

Alignment Length:	436	Identity:	202/436 - (46%)
Similarity:	242/436 - (55%)	Gaps:	95/436 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    76 YGHFNSYASRDFLLGRREAEYGVAGSAGQASAAADSMLFSGFPAQAAELGS---GFGQHPFHSHH 137
            |.|.:.:.:. .:.|..|......|:.|...||......| ..|||...||   .:|.||...:|
Zfish    95 YPHHHHHHNH-HIAGHSEVVSSQTGAFGPVQAATVPYSMS-HTAQALSAGSYPGHYGHHPDPGNH 157

  Fly   138 ------HHH--------------QMRMGM------------------ADAYAAGHPYNHHG---N 161
                  ||.              |:|:|:                  ||.:||...:.:.|   |
Zfish   158 TLFPGLHHDQPSTGAPGGQALNGQIRLGIPAEMYVRSDHLSQVASSRADPFAASPLHGYGGLNLN 222

  Fly   162 FPTAAVHHPVVHHPSHHAMSAMHPAGAGAFLRYMRHQPASSASSVKQEMQCLWIDPDQPGLVPPG 226
            ...:|      ||  ||        |||||.|||| ||      :|||:.|.|::|:.      .
Zfish   223 MNLSA------HH--HH--------GAGAFFRYMR-QP------IKQELICKWLEPEH------S 258

  Fly   227 GRKTCNKVFHSMHEIVTHLTVEHVGGPECTTHACFWVGCSRNGRPFKAKYKLVNHIRVHTGEKPF 291
            .:|.|:|.:.:|||:|||:|||||||||...|.|||..|.|.|:|||||||||||||||||||||
Zfish   259 AKKLCSKTYSTMHELVTHVTVEHVGGPEQANHICFWEECPREGKPFKAKYKLVNHIRVHTGEKPF 323

  Fly   292 ACPHPGCGKVFARSENLKIHKRTHTGEKPFKCEHEGCDRRFANSSDRKKHSHVHTSDKPYNCRIN 356
            .||.|||||||||||||||||||||||||||||.:|||||||||||||||||||||||||||::.
Zfish   324 PCPFPGCGKVFARSENLKIHKRTHTGEKPFKCEFDGCDRRFANSSDRKKHSHVHTSDKPYNCKVR 388

  Fly   357 GCDKSYTHPSSLRKHMKVHGNVDEKSPSHGYDSEGEESSSSSIITGGAQTPPSTRLDGSAGSSSG 421
            |||||||||||||||||||.    |||.   .|.|.|||:.|:::      ||:.|    |....
Zfish   389 GCDKSYTHPSSLRKHMKVHC----KSPP---PSSGYESSTPSLVS------PSSDL----GREPA 436

  Fly   422 VSSLSGGSGIKSSPHSIKSEPNPMHSVHLGASSSGSSSTASSSASH 467
            .|:||......|.|.:: ||....||  .|||...:..:.||:..|
Zfish   437 PSALSEPLSSSSQPANL-SEWYVCHS--SGASGPQTPPSGSSTPGH 479

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
opa	NP_001368991.1	zf_ZIC	206..253	CDD:408166	21/46 (46%)
		C2H2 Zn finger	265..285	CDD:275368	16/19 (84%)
		SFP1	<287..373	CDD:227516	78/85 (92%)
		C2H2 Zn finger	293..315	CDD:275368	20/21 (95%)
		C2H2 Zn finger	323..345	CDD:275368	19/21 (90%)
		C2H2 Zn finger	353..375	CDD:275368	18/21 (86%)
zic4	XP_005162576.1	COG5048	<260..407	CDD:227381	121/146 (83%)
		C2H2 Zn finger	297..317	CDD:275368	16/19 (84%)
		zf-H2C2_2	310..336	CDD:290200	23/25 (92%)
		C2H2 Zn finger	325..347	CDD:275368	20/21 (95%)
		zf-H2C2_2	339..366	CDD:290200	24/26 (92%)
		C2H2 Zn finger	355..377	CDD:275368	19/21 (90%)
		C2H2 Zn finger	385..407	CDD:275368	18/21 (86%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	77	1.000	Domainoid score	I8803
eggNOG	1	0.900	-	-		E33208_3BCH8
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	338	1.000	Inparanoid score	I2344
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D268347at33208
OrthoFinder	1	1.000	-	-		FOG0000467
OrthoInspector	1	1.000	-	-		otm24928
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR19818
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4702
SonicParanoid	1	1.000	-	-		X217
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	10.090