Protein Alignment opa and ZIC3

DIOPT Version :10

• Sequence 1: NP_001368991.1
• Gene: opa / 40605
• FlyBaseID: FBgn0003002
• Length: 688
• Species: Drosophila melanogaster
• Sequence 2: NP_003404.1
• Gene: ZIC3 / 7547
• HGNCID: 12874
• Length: 467
• Species: Homo sapiens
• Alignment Length: 482
• Identity: 195/482 - (40%)
• Similarity: 237/482 - (49%)
• Gaps: 148/482 - (30%)

  Fly    75 GYGHFNSYASRDFLLGRRE-AEYGV---AGSAGQASAAADSMLFSGFPAQAAELGSG-------- 127
            |.|.|.  |.|...:..|| |..|:   ..|...|:|||.:..|...||.|.:|.||
Human    15 GVGSFG--APRHHEMPNREPAGMGLNPFGDSTHAAAAAAAAAAFKLSPAAAHDLSSGQSSAFTPQ 77

  Fly   128 -------FGQHPFHSHHHHH------------------------QMRMGMADAYAAGHPYNHHGN 161
                   .|.|..|.|||||                        |...|:::|.:.|   ..||.
Human    78 GSGYANALGHHHHHHHHHHHTSQVPSYGGAASAAFNSTREFLFRQRSSGLSEAASGG---GQHGL 139

  Fly   162 FPTAA--VHHP--VVHHPSH------HAMSAMHPA------------------------------ 186
            |..:|  :|.|  :...||:      |...|.||:
Human   140 FAGSASSLHAPAGIPEPPSYLLFPGLHEQGAGHPSPTGHVDNNQVHLGLRGELFGRADPYRPVAS 204

  Fly   187 ------------------------------GAGAFLRYMRHQPASSASSVKQEMQCLWIDPDQPG 221
                                          |.|||.|||| ||      :|||:.|.|||..|
Human   205 PRTDPYAAGAQFPNYSPMNMNMGVNVAAHHGPGAFFRYMR-QP------IKQELSCKWIDEAQ-- 260

  Fly   222 LVPPGGRKTCNKVFHSMHEIVTHLTVEHVGGPECTTHACFWVGCSRNGRPFKAKYKLVNHIRVHT 286
            |..|  :|:|::.|.:|||:|||:|:|||||||...|.|:|..|.|.|:.|||||||||||||||
Human   261 LSRP--KKSCDRTFSTMHELVTHVTMEHVGGPEQNNHVCYWEECPREGKSFKAKYKLVNHIRVHT 323

  Fly   287 GEKPFACPHPGCGKVFARSENLKIHKRTHTGEKPFKCEHEGCDRRFANSSDRKKHSHVHTSDKPY 351
            |||||.||.|||||:|||||||||||||||||||||||.||||||||||||||||.|||||||||
Human   324 GEKPFPCPFPGCGKIFARSENLKIHKRTHTGEKPFKCEFEGCDRRFANSSDRKKHMHVHTSDKPY 388

  Fly   352 NCRINGCDKSYTHPSSLRKHMKVHGNVDEKSPSHGYDSEGEESSSSSIITGGAQTPPSTRLDGSA 416
            .|::  ||||||||||||||||||            :|:|.:||.::.....:.|||:.....|.
Human   389 ICKV--CDKSYTHPSSLRKHMKVH------------ESQGSDSSPAASSGYESSTPPAIASANSK 439

  Fly   417 GSSSGVSSLSGGSGIKSSPHSIKSEPN 443
            .::...|::.     .|:.|:....||
Human   440 DTTKTPSAVQ-----TSTSHNPGLPPN 461

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
opa	NP_001368991.1	zf_ZIC	206..253	CDD:436441	24/46 (52%)
		C2H2 Zn finger	265..285	CDD:275368	15/19 (79%)
		SFP1	<287..373	CDD:227516	75/85 (88%)
		C2H2 Zn finger	293..315	CDD:275368	19/21 (90%)
		C2H2 Zn finger	323..345	CDD:275368	19/21 (90%)
		C2H2 Zn finger	353..375	CDD:275368	17/21 (81%)
ZIC3	NP_003404.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	66..107		11/40 (28%)
		zf_ZIC	245..290	CDD:436441	26/54 (48%)
		Nuclear localization signal	297..322		17/24 (71%)
		C2H2 Zn finger	302..322	CDD:275368	15/19 (79%)
		SFP1	<324..408	CDD:227516	75/85 (88%)
		C2H2 Zn finger	330..352	CDD:275368	19/21 (90%)
		Nuclear localization signal	330..352		19/21 (90%)
		C2H2 Zn finger	360..382	CDD:275368	19/21 (90%)
		C2H2 Zn finger	390..410	CDD:275368	17/21 (81%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	404..467		20/75 (27%)