DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment opa and Zxdb

DIOPT Version :9

Sequence 1:	NP_001368991.1	Gene:	opa / 40605	FlyBaseID:	FBgn0003002	Length:	688	Species:	Drosophila melanogaster
Sequence 2:	NP_001074942.1	Gene:	Zxdb / 668166	MGIID:	3694898	Length:	873	Species:	Mus musculus

Alignment Length:	716	Identity:	156/716 - (21%)
Similarity:	225/716 - (31%)	Gaps:	256/716 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 SAAATAAAYQNSGYGHFNSYASRDFLLGRREA------------EYGVA-----------GS--A 102
            :|||.|||:..:...|     ::|.||.....            |.|||           |:  |
Mouse   201 AAAAAAAAFAGTITIH-----NQDLLLRFENGVLTLTTPPLPAWEPGVAPFPQPQPPPQPGALIA 260

  Fly   103 GQASAAADSMLFSGFP------AQAAELGSGFGQHPFHSHHHHHQMRMGM-----ADAYAAGHPY 156
            .||:||       |||      |.||..|:..|..|        ::...:     |:..|...|.
Mouse   261 PQAAAA-------GFPPAAAAAAAAAAAGAQLGDCP--------ELPPDLLLAEPAEPAACPAPP 310

  Fly   157 NHHGNFPTAAVHHPVVHHPSHHAMSAMHPAGAG---AFLRYM------------RHQ-----PAS 201
            ......|.||.           |.|...|||.|   ..:.|:            :||     ...
Mouse   311 EEEAEAPAAAA-----------AQSPRGPAGPGPGPGVVLYLCPEAQCGQTFAKKHQLKVHLLTH 364

  Fly   202 SASSVKQEMQCL-----WI--------------DPDQPGLVPPGGRKTCNKVFHSMHEIVTHLT- 246
            |:|..::..:|.     |.              |..:|...|..|   |.|.|.:::.:..|:.
Mouse   365 SSSQGQRPFKCPLSGCGWTFTTSYKLKRHLQSHDKLRPFGCPVQG---CGKSFTTVYNLKAHMKG 426

  Fly   247 VEHVGGPEC-------------TTH-----------ACFWVGCSRNGRPFKAKYKLVNHIRVHTG 287
            .|.....:|             :||           .|.:.||.:.   |.....|.:|.|.|..
Mouse   427 HEQENSFKCEVCEESFPTQAKLSTHQRSHFEPERPYQCAFSGCKKT---FITVSALFSHNRAHFR 488

  Fly   288 EKP-FACPHPGCGKVFARSENLKIHKRTHTGEKPFKCEHEGCDRRFANSSDRKKHSHVHTSDKPY 351
            |:. |||..|||.|.:.::..||||.|:||||:||.|:.:||...|.:.|...:|...|..|:.:
Mouse   489 EQELFACSFPGCSKQYDKACRLKIHLRSHTGERPFLCDFDGCGWNFTSMSKLLRHKRKHEDDRRF 553

  Fly   352 NCRINGCDKSYTHPSSLRKHMKVH-GNVDEKSPSHGYDSEGEESSSSSI---------------- 399
            .|.:.||.||:|....|:.|...| |......|..|..:.....||..|
Mouse   554 TCPVEGCGKSFTRAEHLKGHSITHLGTKPFVCPVEGCCARFSARSSLYIHSKKHLQDVGAWKSRC 618

  Fly   400 --------------------------------ITGGAQTPPSTRLDGSAGSSSGVSSLSG----- 427
                                            :.......||:.|     :|.|.|.|||
Mouse   619 PVPTCNKLFTSKHSMKTHMTKRHNLSQDLLAQLEAANSLTPSSEL-----TSPGQSDLSGAELVS 678

  Fly   428 --------GSGIKSSPHSIKSEPNPMHSVHLGASSSGSSSTASSSASHLLQHQQHQHQQQQQQQQ 484
                    ||........:.|....:....:.:|.:||....::|.:|.|
Mouse   679 LFSDVPGHGSAAVLDTALVNSGILTIDVASVNSSLAGSLPADNNSNNHSL--------------- 728

  Fly   485 HQQQAQQQQQLTAHPSD-PKSSPALQLMAASASAYLPPPL-------------GPPPSHHHHPHH 535
              .||.:.:.|...||| |:|.........|.:.|...||             |.....:.....
Mouse   729 --GQAAEPRALRGAPSDLPQSLDTSLFFGTSVAGYQHSPLDMDDVSAGNVGLFGSLALKNSSLEP 791

  Fly   536 HQAAPS------PGAAAASASMLHHNHHLLYHPAAQH---HPPSDWY-----------HTTAPSG 580
            ....||      ..|...|:::..::...|..||...   ||.||::           |.|...|
Mouse   792 QALTPSNKLTVDTEALTPSSTLCENSVSELLTPAKAEWNVHPESDFFGHEEETQFGFSHPTGSHG 856

  Fly   581 S 581
            |
Mouse   857 S 857

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
opa	NP_001368991.1	zf_ZIC	206..253	CDD:408166	11/66 (17%)
		C2H2 Zn finger	265..285	CDD:275368	5/19 (26%)
		SFP1	<287..373	CDD:227516	35/86 (41%)
		C2H2 Zn finger	293..315	CDD:275368	10/21 (48%)
		C2H2 Zn finger	323..345	CDD:275368	6/21 (29%)
		C2H2 Zn finger	353..375	CDD:275368	8/21 (38%)
Zxdb	NP_001074942.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..23
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	48..120
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	138..184
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	240..259		5/18 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	301..330		9/39 (23%)
		Required for interaction with ZXDC. /evidence=ECO:0000250	340..646		69/311 (22%)
		C2H2 Zn finger	342..364	CDD:275368	2/21 (10%)
		zf-C2H2_aberr	373..518	CDD:293622	35/150 (23%)
		C2H2 Zn finger	375..397	CDD:275368	2/21 (10%)
		C2H2 Zn finger	405..427	CDD:275368	6/24 (25%)
		zf-H2C2_2	419..442	CDD:290200	3/22 (14%)
		C2H2 Zn finger	435..455	CDD:275368	3/19 (16%)
		C2H2 Zn finger	464..486	CDD:275368	7/24 (29%)
		C2H2 Zn finger	498..517	CDD:275368	9/18 (50%)
		COG5048	<510..642	CDD:227381	34/131 (26%)
		C2H2 Zn finger	525..547	CDD:275368	6/21 (29%)
		C2H2 Zn finger	555..577	CDD:275368	8/21 (38%)
		C2H2 Zn finger	585..607	CDD:275370	5/21 (24%)
		Required for transcriptional activation. /evidence=ECO:0000250	645..776		30/152 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167847746
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930