Protein Alignment opa and Zic5

DIOPT Version :10

• Sequence 1: NP_001368991.1
• Gene: opa / 40605
• FlyBaseID: FBgn0003002
• Length: 688
• Species: Drosophila melanogaster
• Sequence 2: NP_075363.1
• Gene: Zic5 / 65100
• MGIID: 1929518
• Length: 622
• Species: Mus musculus
• Alignment Length: 497
• Identity: 205/497 - (41%)
• Similarity: 249/497 - (50%)
• Gaps: 143/497 - (28%)

  Fly    65 AATAAAYQNSGYGHFNSYASRDFLLGRRE--------AEYGVAGSAGQASAAAD----------- 110
            |..:....:||.||     ||||:| ||:        |.:|......|.|.::.
Mouse   157 ATNSGGGSSSGKGH-----SRDFVL-RRDLSATAPAAAMHGAPLGGEQRSGSSSPQHPTPPPHPA 215

  Fly   111 SMLFSGFPAQAAELGSGF-------------GQHPFHSHHHHHQMRMGMADAYAAG--------- 153
            .|..|.....|...|.|.             |.||.:.     |||:|:|.|.||.
Mouse   216 GMFISASGTYAGRDGGGSALFPALHDSPGAPGGHPLNG-----QMRLGLAAAAAAAAELYGRAEP 275

  Fly   154 ----------------------HPY---NHHGNFPTAAV------------HH-----------P 170
                                  |.|   |.:.|...||.            ||           |
Mouse   276 PFAPRSGDAHYGAVAAAAAAALHGYGAVNLNLNLAAAAAAAAAAGPGPHLQHHAPPPAPPPAPAP 340

  Fly   171 VVHHPSHHAMSAMHPAGAGAFLRYMRHQPASSASSVKQEMQCLWIDPDQ---PGLVPPGGRKTCN 232
            ..|||  |.     |..||||||||| ||      :|:|:.|.|:||::   |......|.|.|:
Mouse   341 HPHHP--HL-----PGAAGAFLRYMR-QP------IKRELICKWLDPEELAGPPASADSGVKPCS 391

  Fly   233 KVFHSMHEIVTHLTVEHVGGPECTTHACFWVGCSRNGRPFKAKYKLVNHIRVHTGEKPFACPHPG 297
            |.|.:|||:|.|:|||||||||.::|.|||..|.|.|:||||||||:||||||||||||.||.||
Mouse   392 KTFGTMHELVNHVTVEHVGGPEQSSHVCFWEDCPREGKPFKAKYKLINHIRVHTGEKPFPCPFPG 456

  Fly   298 CGKVFARSENLKIHKRTHTGEKPFKCEHEGCDRRFANSSDRKKHSHVHTSDKPYNCRINGCDKSY 362
            |||||||||||||||||||||||||||.:||||:||||||||||||||||||||.|:|.||||||
Mouse   457 CGKVFARSENLKIHKRTHTGEKPFKCEFDGCDRKFANSSDRKKHSHVHTSDKPYYCKIRGCDKSY 521

  Fly   363 THPSSLRKHMKVHGNVDEKSP-SHGYDSEG-------------EESSSSSIITGGAQTPPSTRLD 413
            |||||||||||:|......|| :.||.|.|             ..|.||::      :|..|.|:
Mouse   522 THPSSLRKHMKIHCKSPPPSPGALGYSSVGTPVGDPLSPVLDPTRSRSSTL------SPQVTNLN 580

  Fly   414 -----GSAGSSSGV-SSLSGGSGIKSSPHSIKSEPNPMHSVH 449
                 .::|:.|.: :..|.|:..:|....:...|..|.::|
Mouse   581 EWYVCQASGAPSHLHTPSSNGTTSESEDEEMYGNPEVMRTIH 622

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
opa	NP_001368991.1	zf_ZIC	206..253	CDD:436441	23/49 (47%)
		C2H2 Zn finger	265..285	CDD:275368	15/19 (79%)
		SFP1	<287..373	CDD:227516	77/85 (91%)
		C2H2 Zn finger	293..315	CDD:275368	20/21 (95%)
		C2H2 Zn finger	323..345	CDD:275368	18/21 (86%)
		C2H2 Zn finger	353..375	CDD:275368	19/21 (90%)
Zic5	NP_075363.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	50..171		5/18 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	190..223		5/32 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	232..251		3/18 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	321..349		7/34 (21%)
		zf_ZIC	360..412	CDD:436441	25/57 (44%)
		COG5048	<388..550	CDD:227381	124/161 (77%)
		C2H2 Zn finger	424..444	CDD:275368	15/19 (79%)
		C2H2 Zn finger	452..474	CDD:275368	20/21 (95%)
		C2H2 Zn finger	482..504	CDD:275368	18/21 (86%)
		C2H2 Zn finger	512..534	CDD:275368	19/21 (90%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	531..573		12/47 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	590..622		6/31 (19%)