DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment opa and Zic5

DIOPT Version :9

Sequence 1:	NP_001368991.1	Gene:	opa / 40605	FlyBaseID:	FBgn0003002	Length:	688	Species:	Drosophila melanogaster
Sequence 2:	NP_075363.1	Gene:	Zic5 / 65100	MGIID:	1929518	Length:	622	Species:	Mus musculus

Alignment Length:	498	Identity:	205/498 - (41%)
Similarity:	249/498 - (50%)	Gaps:	145/498 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 AATAAAYQNSGYGHFNSYASRDFLLGRRE--------AEYGVAGSAGQASAAAD----------- 110
            |..:....:||.||     ||||:| ||:        |.:|......|.|.::.
Mouse   157 ATNSGGGSSSGKGH-----SRDFVL-RRDLSATAPAAAMHGAPLGGEQRSGSSSPQHPTPPPHPA 215

  Fly   111 SMLFSGFPAQAAELGSGF-------------GQHPFHSHHHHHQMRMGMADAYAAG--------- 153
            .|..|.....|...|.|.             |.||.:.     |||:|:|.|.||.
Mouse   216 GMFISASGTYAGRDGGGSALFPALHDSPGAPGGHPLNG-----QMRLGLAAAAAAAAELYGRAEP 275

  Fly   154 ----------------------HPY---NHHGNFPTAAV------------HH-----------P 170
                                  |.|   |.:.|...||.            ||           |
Mouse   276 PFAPRSGDAHYGAVAAAAAAALHGYGAVNLNLNLAAAAAAAAAAGPGPHLQHHAPPPAPPPAPAP 340

  Fly   171 VVHHPSHHAMSAMH-PAGAGAFLRYMRHQPASSASSVKQEMQCLWIDPDQ---PGLVPPGGRKTC 231
            ..|||        | |..||||||||| ||      :|:|:.|.|:||::   |......|.|.|
Mouse   341 HPHHP--------HLPGAAGAFLRYMR-QP------IKRELICKWLDPEELAGPPASADSGVKPC 390

  Fly   232 NKVFHSMHEIVTHLTVEHVGGPECTTHACFWVGCSRNGRPFKAKYKLVNHIRVHTGEKPFACPHP 296
            :|.|.:|||:|.|:|||||||||.::|.|||..|.|.|:||||||||:||||||||||||.||.|
Mouse   391 SKTFGTMHELVNHVTVEHVGGPEQSSHVCFWEDCPREGKPFKAKYKLINHIRVHTGEKPFPCPFP 455

  Fly   297 GCGKVFARSENLKIHKRTHTGEKPFKCEHEGCDRRFANSSDRKKHSHVHTSDKPYNCRINGCDKS 361
            ||||||||||||||||||||||||||||.:||||:||||||||||||||||||||.|:|.|||||
Mouse   456 GCGKVFARSENLKIHKRTHTGEKPFKCEFDGCDRKFANSSDRKKHSHVHTSDKPYYCKIRGCDKS 520

  Fly   362 YTHPSSLRKHMKVHGNVDEKSP-SHGYDSEG-------------EESSSSSIITGGAQTPPSTRL 412
            ||||||||||||:|......|| :.||.|.|             ..|.||::      :|..|.|
Mouse   521 YTHPSSLRKHMKIHCKSPPPSPGALGYSSVGTPVGDPLSPVLDPTRSRSSTL------SPQVTNL 579

  Fly   413 D-----GSAGSSSGV-SSLSGGSGIKSSPHSIKSEPNPMHSVH 449
            :     .::|:.|.: :..|.|:..:|....:...|..|.::|
Mouse   580 NEWYVCQASGAPSHLHTPSSNGTTSESEDEEMYGNPEVMRTIH 622

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
opa	NP_001368991.1	zf_ZIC	206..253	CDD:408166	23/49 (47%)
		C2H2 Zn finger	265..285	CDD:275368	15/19 (79%)
		SFP1	<287..373	CDD:227516	77/85 (91%)
		C2H2 Zn finger	293..315	CDD:275368	20/21 (95%)
		C2H2 Zn finger	323..345	CDD:275368	18/21 (86%)
		C2H2 Zn finger	353..375	CDD:275368	19/21 (90%)
Zic5	NP_075363.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	50..171		5/18 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	190..223		5/32 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	232..251		3/18 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	321..349		7/35 (20%)
		COG5048	<388..550	CDD:227381	124/161 (77%)
		C2H2 Zn finger	424..444	CDD:275368	15/19 (79%)
		zf-H2C2_2	437..463	CDD:290200	22/25 (88%)
		C2H2 Zn finger	452..474	CDD:275368	20/21 (95%)
		zf-H2C2_2	466..493	CDD:290200	23/26 (88%)
		C2H2 Zn finger	482..504	CDD:275368	18/21 (86%)
		zf-C2H2	510..534	CDD:278523	20/23 (87%)
		C2H2 Zn finger	512..534	CDD:275368	19/21 (90%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	531..573		12/47 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	590..622		6/31 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	76	1.000	Domainoid score	I8938
eggNOG	1	0.900	-	-		E33208_3BCH8
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	339	1.000	Inparanoid score	I2352
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D268347at33208
OrthoFinder	1	1.000	-	-		FOG0000467
OrthoInspector	1	1.000	-	-		otm43260
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR19818
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X217
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	9.060