DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment opa and zic2a

DIOPT Version :9

Sequence 1:	NP_001368991.1	Gene:	opa / 40605	FlyBaseID:	FBgn0003002	Length:	688	Species:	Drosophila melanogaster
Sequence 2:	NP_571633.1	Gene:	zic2a / 58077	ZFINID:	ZDB-GENE-000710-4	Length:	445	Species:	Danio rerio

Alignment Length:	495	Identity:	214/495 - (43%)
Similarity:	254/495 - (51%)	Gaps:	109/495 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 AQHHLASYGLRMSPNTTASNSNAQQQQQQQLEMTQQQQQQQQQQQQQQQQDQESAAATAAAYQNS 74
            |:||.:|..::....:.|.||..........::.......|......|.....:||..|.|
Zfish    18 ARHHHSSSEMQDRDLSLAQNSFVDSAHMGAFKLNHDLSPGQSSAFTSQAPGYPAAALGAHA---- 78

  Fly    75 GYGHFNSYAS------RDFLLGRREAEYGVAGSAGQASAA------------ADS---MLFSGFP 118
              .|..||||      ||||.  |...:|.:..||...|.            .||   :||.|..
Zfish    79 --AHVTSYASSPFNSTRDFLF--RSRGFGESSPAGGQHALFGPTAGSLHHSHTDSQGHILFPGIH 139

  Fly   119 AQAAELGS----------GFGQHPFHSHHHHHQMRMGMADAYAAGHPYNHHGNF-----PTAAVH 168
            .|....||          |.....|.....:||:.....|.|:|...:|.:|:.     ...|.|
Zfish   140 EQHGSHGSPNVLNGQMRLGLPGEVFGRSDQYHQVSSPRTDPYSAAQLHNQYGSMNMNMGMNMAAH 204

  Fly   169 HPVVHHPSHHAMSAMHPAGAGAFLRYMRHQPASSASSVKQEMQCLWIDPDQPGLVPPGGRKTCNK 233
            |   |||             |||.||||.|      .:|||:.|.||||:|  |..|  :|:|||
Zfish   205 H---HHP-------------GAFFRYMRQQ------CIKQELICKWIDPEQ--LSNP--KKSCNK 243

  Fly   234 VFHSMHEIVTHLTVEHVGGPECTTHACFWVGCSRNGRPFKAKYKLVNHIRVHTGEKPFACPHPGC 298
            .|.:|||:|||::||||||||.:.|.|||..|.|..:|||||||||||||||||||||.||.|||
Zfish   244 TFSTMHELVTHVSVEHVGGPEQSNHICFWEECPRESKPFKAKYKLVNHIRVHTGEKPFPCPFPGC 308

  Fly   299 GKVFARSENLKIHKRTHTGEKPFKCEHEGCDRRFANSSDRKKHSHVHTSDKPYNCRINGCDKSYT 363
            |||||||||||||||||||||||:||.||||||||||||||||.|||||||||.|::  ||||||
Zfish   309 GKVFARSENLKIHKRTHTGEKPFQCEFEGCDRRFANSSDRKKHMHVHTSDKPYLCKM--CDKSYT 371

  Fly   364 HPSSLRKHMKVHGNVDEKSPSHGYDSEGEESSSSSIITGGAQTPPSTRLDGSAGSSSGVSSLSGG 428
            ||||||||||||                 |||           ||::  |.|..:|||..| |..
Zfish   372 HPSSLRKHMKVH-----------------ESS-----------PPAS--DSSPAASSGYES-STP 405

  Fly   429 SGIKSSPHSIKSEPN--PMHSVHLGASSSGSSSTASSSAS 466
            .|:.|.....:|..|  |..:||    ||.:.|:.||:.|
Zfish   406 PGLVSPSTETQSNNNLSPSSAVH----SSNNHSSLSSNFS 441

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
opa	NP_001368991.1	zf_ZIC	206..253	CDD:408166	27/46 (59%)
		C2H2 Zn finger	265..285	CDD:275368	15/19 (79%)
		SFP1	<287..373	CDD:227516	75/85 (88%)
		C2H2 Zn finger	293..315	CDD:275368	20/21 (95%)
		C2H2 Zn finger	323..345	CDD:275368	19/21 (90%)
		C2H2 Zn finger	353..375	CDD:275368	17/21 (81%)
zic2a	NP_571633.1	C2H2 Zn finger	275..295	CDD:275368	15/19 (79%)
		zf-H2C2_2	288..314	CDD:290200	23/25 (92%)
		C2H2 Zn finger	303..325	CDD:275368	20/21 (95%)
		zf-H2C2_2	317..344	CDD:290200	24/26 (92%)
		C2H2 Zn finger	333..355	CDD:275368	19/21 (90%)
		zf-C2H2	361..383	CDD:278523	18/23 (78%)
		C2H2 Zn finger	363..383	CDD:275368	17/21 (81%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	68	1.000	Domainoid score	I9679
eggNOG	1	0.900	-	-		E33208_3BCH8
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	338	1.000	Inparanoid score	I2344
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000467
OrthoInspector	1	1.000	-	-		otm24928
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19818
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4702
SonicParanoid	1	1.000	-	-		X217
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	9.080