DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment opa and Zic3

DIOPT Version :9

Sequence 1:	NP_001368991.1	Gene:	opa / 40605	FlyBaseID:	FBgn0003002	Length:	688	Species:	Drosophila melanogaster
Sequence 2:	XP_038955884.1	Gene:	Zic3 / 367944	RGDID:	1561261	Length:	466	Species:	Rattus norvegicus

Alignment Length:	485	Identity:	202/485 - (41%)
Similarity:	251/485 - (51%)	Gaps:	104/485 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 EPAQHHLASYG--------------LRMSPNTTASNSNAQQQQQQQLEMTQQQQQQQQQQQQQQQ 58
            |||...|..:|              .::||.|....|:.|..     ..|.|.............
  Rat    31 EPAAMGLNPFGDSTHAAAAAAAAAAFKLSPATAHDLSSGQSS-----AFTPQGSGYANALGHHHH 90

  Fly    59 QDQESAAATAAAYQNSGYGHFNSYASRDFLLGRR-----EAEYG------VAGSAGQASAAA--- 109
            ......|:....|..:....|||  :||||..:|     ||..|      .||||....|.|
  Rat    91 HHHHHHASQVPTYGGAASAAFNS--TRDFLFRQRGSGLSEAASGGGQHGLFAGSASSLHAPAGIP 153

  Fly   110 ---DSMLFSGFPAQAAELGSGFGQHPFHSHH-HHHQMRMGM-------ADAY-----AAGHPYNH 158
               ..:||.|...|    |:|   ||..:.| .::|:.:|:       ||.|     ....||..
  Rat   154 EPPSYLLFPGLHEQ----GAG---HPSPTGHVDNNQVHLGLRGELFGRADPYRPVASPRTDPYAA 211

  Fly   159 HGNFPTAAVHHPV-----VHHPSHHAMSAMHPAGAGAFLRYMRHQPASSASSVKQEMQCLWIDPD 218
            ...||.   :.|:     |:..:||        |.|||.|||| ||      :|||:.|.||:..
  Rat   212 SAQFPN---YSPMNMNMGVNVAAHH--------GPGAFFRYMR-QP------IKQELSCKWIEEA 258

  Fly   219 QPGLVPPGGRKTCNKVFHSMHEIVTHLTVEHVGGPECTTHACFWVGCSRNGRPFKAKYKLVNHIR 283
            |  |..|  :|:|::.|.:|||:|||:|:|||||||...|.|:|..|.|.|:.||||||||||||
  Rat   259 Q--LSRP--KKSCDRTFSTMHELVTHVTMEHVGGPEQNNHVCYWEECPREGKSFKAKYKLVNHIR 319

  Fly   284 VHTGEKPFACPHPGCGKVFARSENLKIHKRTHTGEKPFKCEHEGCDRRFANSSDRKKHSHVHTSD 348
            ||||||||.||.|||||:|||||||||||||||||||||||.||||||||||||||||.||||||
  Rat   320 VHTGEKPFPCPFPGCGKIFARSENLKIHKRTHTGEKPFKCEFEGCDRRFANSSDRKKHMHVHTSD 384

  Fly   349 KPYNCRINGCDKSYTHPSSLRKHMKVHGNVDEKSPSHGYDSEGEESSSSSIITGGAQTPPSTRLD 413
            |||.|::  ||||||||||||||||||            :|:|.:||.::.....:.|||:....
  Rat   385 KPYICKV--CDKSYTHPSSLRKHMKVH------------ESQGSDSSPAASSGYESSTPPAIASA 435

  Fly   414 GSAGSSSGVSSLSGGSGIKSSPHSIKSEPN 443
            .|..::...|::.     .|:.|:....||
  Rat   436 NSKDTTKTPSAVQ-----TSTSHNPGLPPN 460

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
opa	NP_001368991.1	zf_ZIC	206..253	CDD:408166	23/46 (50%)
		C2H2 Zn finger	265..285	CDD:275368	15/19 (79%)
		SFP1	<287..373	CDD:227516	75/85 (88%)
		C2H2 Zn finger	293..315	CDD:275368	19/21 (90%)
		C2H2 Zn finger	323..345	CDD:275368	19/21 (90%)
		C2H2 Zn finger	353..375	CDD:275368	17/21 (81%)
Zic3	XP_038955884.1	zf_ZIC	244..289	CDD:408166	25/54 (46%)
		C2H2 Zn finger	301..321	CDD:275368	15/19 (79%)
		SFP1	<323..407	CDD:227516	75/85 (88%)
		C2H2 Zn finger	329..351	CDD:275368	19/21 (90%)
		C2H2 Zn finger	359..381	CDD:275368	19/21 (90%)
		C2H2 Zn finger	389..409	CDD:275368	17/21 (81%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	64	1.000	Domainoid score	I9867
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	334	1.000	Inparanoid score	I2326
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000467
OrthoInspector	1	1.000	-	-		otm45332
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19818
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X217
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	8.150