DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment opa and Zic4

DIOPT Version :9

Sequence 1:	NP_001368991.1	Gene:	opa / 40605	FlyBaseID:	FBgn0003002	Length:	688	Species:	Drosophila melanogaster
Sequence 2:	NP_001381057.1	Gene:	Zic4 / 315882	RGDID:	1307298	Length:	334	Species:	Rattus norvegicus

Alignment Length:	315	Identity:	170/315 - (53%)
Similarity:	202/315 - (64%)	Gaps:	38/315 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   104 QASAAADSMLFSGF---PAQAAELGSGFGQHPFHSHHHHHQMRMGM-ADAYAAGHPY-----NHH 159
            |.:||::..:|.|.   |.||:           ||...:..:|:|: .|.||...|:     ...
  Rat    33 QLAAASNPSVFPGLHEQPPQAS-----------HSRPLNGLLRLGIPGDMYARSEPFAPGPMARG 86

  Fly   160 GNFPTAAVHHPVVHHPSHHAMSAMHPAGAGAFLRYMRHQPASSASSVKQEMQCLWIDPDQPGLVP 224
            ....||...|.  :...:..|:...|.|.|||.|||| ||      :|||:.|.|:..|.|  :.
  Rat    87 DTLATATALHG--YGGMNLTMNLTAPHGPGAFFRYMR-QP------IKQELICKWLGDDSP--IS 140

  Fly   225 PGGRKTCNKVFHSMHEIVTHLTVEHVGGPECTTHACFWVGCSRNGRPFKAKYKLVNHIRVHTGEK 289
            |   :.|:|.|.:|||:|||:|||||||||...|.|||..|.|.|:|||||||||||||||||||
  Rat   141 P---RPCSKTFSTMHELVTHVTVEHVGGPEQANHICFWEECPRQGKPFKAKYKLVNHIRVHTGEK 202

  Fly   290 PFACPHPGCGKVFARSENLKIHKRTHTGEKPFKCEHEGCDRRFANSSDRKKHSHVHTSDKPYNCR 354
            ||.||.||||||||||||||||||||||||||:||.|||:||||||||||||||||||||||.|:
  Rat   203 PFPCPFPGCGKVFARSENLKIHKRTHTGEKPFRCEFEGCERRFANSSDRKKHSHVHTSDKPYMCK 267

  Fly   355 INGCDKSYTHPSSLRKHMKVHGNVDEKSPSHGYDSEGEESSSSSIITGGAQTPPS 409
            :.||||.|||||||||||||||.  ...||.||||....:.:|:.:..|.:  ||
  Rat   268 VRGCDKCYTHPSSLRKHMKVHGR--SPPPSSGYDSAITSALTSTSLESGRE--PS 318

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
opa	NP_001368991.1	zf_ZIC	206..253	CDD:408166	23/46 (50%)
		C2H2 Zn finger	265..285	CDD:275368	16/19 (84%)
		SFP1	<287..373	CDD:227516	75/85 (88%)
		C2H2 Zn finger	293..315	CDD:275368	20/21 (95%)
		C2H2 Zn finger	323..345	CDD:275368	19/21 (90%)
		C2H2 Zn finger	353..375	CDD:275368	17/21 (81%)
Zic4	NP_001381057.1	zf_ZIC	122..166	CDD:408166	25/54 (46%)
		COG5048	<131..288	CDD:227381	122/161 (76%)
		C2H2 Zn finger	178..198	CDD:275368	16/19 (84%)
		C2H2 Zn finger	206..228	CDD:275368	20/21 (95%)
		C2H2 Zn finger	236..258	CDD:275368	19/21 (90%)
		C2H2 Zn finger	266..288	CDD:275368	17/21 (81%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	76	1.000	Domainoid score	I8764
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	334	1.000	Inparanoid score	I2326
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000467
OrthoInspector	1	1.000	-	-		otm45332
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19818
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X217
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	8.150