DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment opa and zic1

DIOPT Version :9

Sequence 1:	NP_001368991.1	Gene:	opa / 40605	FlyBaseID:	FBgn0003002	Length:	688	Species:	Drosophila melanogaster
Sequence 2:	NP_571008.1	Gene:	zic1 / 30096	ZFINID:	ZDB-GENE-000208-4	Length:	442	Species:	Danio rerio

Alignment Length:	444	Identity:	210/444 - (47%)
Similarity:	251/444 - (56%)	Gaps:	106/444 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 QESAAATAAAYQNSGYGH--------------FNSYASRDFLLGRR------EAEYGVAGSAGQA 105
            |.:.::.|..|..:..||              |||  :||||...|      .|::.:..||..:
Zfish    60 QTAFSSQAPGYAAAALGHHHHPTHVSSYSTAAFNS--TRDFLFRNRGFGDATSAQHSLFASAAGS 122

  Fly   106 -------SAAADSMLFSGFPAQAAELGSGFGQHPFHSHHHHHQMRMGMA-DAYAAGHPYNH---- 158
                   |.||..:||.|...|||...|        |:..:.|||:|.: |.|.....|.|
Zfish   123 FAGPHGHSDAAGHLLFPGLHEQAATHAS--------SNVVNSQMRLGFSGDMYGRAEQYGHVASP 179

  Fly   159 -HGNFPTAAVHHPVVHHPSHHAMSAMHPAGAGAFLRYMRHQPASSASSVKQEMQCLWIDPDQPGL 222
             ..::.:..:|.   :.|.:..|:|.|  |||||.|||| ||      :|||:.|.||:|:|  |
Zfish   180 RSEHYASTQLHG---YGPMNMNMAAHH--GAGAFFRYMR-QP------IKQELICKWIEPEQ--L 230

  Fly   223 VPPGGRKTCNKVFHSMHEIVTHLTVEHVGGPECTTHACFWVGCSRNGRPFKAKYKLVNHIRVHTG 287
            ..|  :|:|||.|.:|||:|||||||||||||.:.|.|||..|.|.|:|||||||||||||||||
Zfish   231 TNP--KKSCNKTFSTMHELVTHLTVEHVGGPEQSNHICFWEECGREGKPFKAKYKLVNHIRVHTG 293

  Fly   288 EKPFACPHPGCGKVFARSENLKIHKRTHTGEKPFKCEHEGCDRRFANSSDRKKHSHVHTSDKPYN 352
            ||||.||.|||||||||||||||||||||||||||||.||||||||||||||||.|||||||||.
Zfish   294 EKPFPCPFPGCGKVFARSENLKIHKRTHTGEKPFKCEFEGCDRRFANSSDRKKHMHVHTSDKPYL 358

  Fly   353 CRINGCDKSYTHPSSLRKHMKVHGNVDEKSPSHGYDSEGEESSSSSIITGGAQTPPSTRLDGSAG 417
            |::  ||||||||||||||||||                 ||||.     |:|..|:
Zfish   359 CKM--CDKSYTHPSSLRKHMKVH-----------------ESSSQ-----GSQPSPA-------- 391

  Fly   418 SSSGVSSLSGGSGIKSSPHSIKSEPNPMHSVHLGASSSGSSSTASSSASHLLQH 471
            :|||..|        |:|.:|.| |:..:      .||.|.|.|||:..|...|
Zfish   392 ASSGYES--------STPPTIVS-PSTEN------QSSSSISPASSTVHHTSSH 430

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
opa	NP_001368991.1	zf_ZIC	206..253	CDD:408166	28/46 (61%)
		C2H2 Zn finger	265..285	CDD:275368	16/19 (84%)
		SFP1	<287..373	CDD:227516	76/85 (89%)
		C2H2 Zn finger	293..315	CDD:275368	20/21 (95%)
		C2H2 Zn finger	323..345	CDD:275368	19/21 (90%)
		C2H2 Zn finger	353..375	CDD:275368	17/21 (81%)
zic1	NP_571008.1	C2H2 Zn finger	269..291	CDD:275368	16/21 (76%)
		zf-H2C2_2	284..310	CDD:290200	23/25 (92%)
		C2H2 Zn finger	299..321	CDD:275368	20/21 (95%)
		zf-H2C2_2	313..340	CDD:290200	25/26 (96%)
		C2H2 Zn finger	329..351	CDD:275368	19/21 (90%)
		zf-C2H2	357..379	CDD:278523	18/23 (78%)
		C2H2 Zn finger	359..379	CDD:275368	17/21 (81%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	68	1.000	Domainoid score	I9679
eggNOG	1	0.900	-	-		E33208_3BCH8
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	338	1.000	Inparanoid score	I2344
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000467
OrthoInspector	1	1.000	-	-		otm24928
orthoMCL	1	0.900	-	-		OOG6_109627
Panther	1	1.100	-	-	O	PTHR19818
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X217
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.950