Protein Alignment opa and Zic3

DIOPT Version :10

• Sequence 1: NP_001368991.1
• Gene: opa / 40605
• FlyBaseID: FBgn0003002
• Length: 688
• Species: Drosophila melanogaster
• Sequence 2: NP_033601.2
• Gene: Zic3 / 22773
• MGIID: 106676
• Length: 466
• Species: Mus musculus
• Alignment Length: 485
• Identity: 202/485 - (41%)
• Similarity: 251/485 - (51%)
• Gaps: 104/485 - (21%)

  Fly     8 EPAQHHLASYG--------------LRMSPNTTASNSNAQQQQQQQLEMTQQQQQQQQQQQQQQQ 58
            |||...|..:|              .::||.|....|:.|..     ..|.|.............
Mouse    31 EPAGMGLNPFGDSTHAAAAAAAAAAFKLSPATAHDLSSGQSS-----AFTPQGSGYANALGHHHH 90

  Fly    59 QDQESAAATAAAYQNSGYGHFNSYASRDFLLGRR-----EAEYG------VAGSAGQASAAA--- 109
            ......|:....|..:....|||  :||||..:|     ||..|      .||||....|.|
Mouse    91 HHHHHHASQVPTYGGAASAAFNS--TRDFLFRQRGSGLSEAASGGGQHGLFAGSASSLHAPAGIP 153

  Fly   110 ---DSMLFSGFPAQAAELGSGFGQHPFHSHH-HHHQMRMGM-------ADAY-----AAGHPYNH 158
               ..:||.|...|    |:|   ||..:.| .::|:.:|:       ||.|     ....||..
Mouse   154 EPPSYLLFPGLHEQ----GAG---HPSPTGHVDNNQVHLGLRGELFGRADPYRPVASPRTDPYAA 211

  Fly   159 HGNFPTAAVHHPV-----VHHPSHHAMSAMHPAGAGAFLRYMRHQPASSASSVKQEMQCLWIDPD 218
            ...||.   :.|:     |:..:||        |.|||.|||| ||      :|||:.|.||:..
Mouse   212 SAQFPN---YSPMNMNMGVNVAAHH--------GPGAFFRYMR-QP------IKQELSCKWIEEA 258

  Fly   219 QPGLVPPGGRKTCNKVFHSMHEIVTHLTVEHVGGPECTTHACFWVGCSRNGRPFKAKYKLVNHIR 283
            |  |..|  :|:|::.|.:|||:|||:|:|||||||...|.|:|..|.|.|:.||||||||||||
Mouse   259 Q--LSRP--KKSCDRTFSTMHELVTHVTMEHVGGPEQNNHVCYWEECPREGKSFKAKYKLVNHIR 319

  Fly   284 VHTGEKPFACPHPGCGKVFARSENLKIHKRTHTGEKPFKCEHEGCDRRFANSSDRKKHSHVHTSD 348
            ||||||||.||.|||||:|||||||||||||||||||||||.||||||||||||||||.||||||
Mouse   320 VHTGEKPFPCPFPGCGKIFARSENLKIHKRTHTGEKPFKCEFEGCDRRFANSSDRKKHMHVHTSD 384

  Fly   349 KPYNCRINGCDKSYTHPSSLRKHMKVHGNVDEKSPSHGYDSEGEESSSSSIITGGAQTPPSTRLD 413
            |||.|::  ||||||||||||||||||            :|:|.:||.::.....:.|||:....
Mouse   385 KPYICKV--CDKSYTHPSSLRKHMKVH------------ESQGSDSSPAASSGYESSTPPAIASA 435

  Fly   414 GSAGSSSGVSSLSGGSGIKSSPHSIKSEPN 443
            .|..::...|::.     .|:.|:....||
Mouse   436 NSKDTTKTPSAVQ-----TSTSHNPGLPPN 460

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
opa	NP_001368991.1	zf_ZIC	206..253	CDD:436441	23/46 (50%)
		C2H2 Zn finger	265..285	CDD:275368	15/19 (79%)
		SFP1	<287..373	CDD:227516	75/85 (88%)
		C2H2 Zn finger	293..315	CDD:275368	19/21 (90%)
		C2H2 Zn finger	323..345	CDD:275368	19/21 (90%)
		C2H2 Zn finger	353..375	CDD:275368	17/21 (81%)
Zic3	NP_033601.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	65..103		5/42 (12%)
		zf_ZIC	244..289	CDD:436441	25/54 (46%)
		Nuclear localization signal. /evidence=ECO:0000250	296..321		17/24 (71%)
		C2H2 Zn finger	301..321	CDD:275368	15/19 (79%)
		SFP1	<323..407	CDD:227516	75/85 (88%)
		C2H2 Zn finger	329..351	CDD:275368	19/21 (90%)
		Nuclear localization signal. /evidence=ECO:0000250	329..351		19/21 (90%)
		C2H2 Zn finger	359..381	CDD:275368	19/21 (90%)
		C2H2 Zn finger	389..409	CDD:275368	17/21 (81%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	403..466		20/75 (27%)