DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment opa and Zic1

DIOPT Version :9

Sequence 1:	NP_001368991.1	Gene:	opa / 40605	FlyBaseID:	FBgn0003002	Length:	688	Species:	Drosophila melanogaster
Sequence 2:	NP_001363870.1	Gene:	Zic1 / 22771	MGIID:	106683	Length:	447	Species:	Mus musculus

Alignment Length:	467	Identity:	217/467 - (46%)
Similarity:	253/467 - (54%)	Gaps:	104/467 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 MNAF-IEPAQHHLASYGLRMSPNTTASNSNAQQQQQQQLEMTQQQQQQQQQQQQQQQQDQESAAA 66
            |.|| :.|:.|.|||.|      .||..|.|                             ...||
Mouse    44 MGAFKLNPSSHELASAG------QTAFTSQA-----------------------------PGYAA 73

  Fly    67 TAAAYQNSGYGHFNSYAS------RDFLLGRREAEYGVAGSAGQASA------------------ 107
            .||...:...||..||:|      ||||...|    |...:|..|||
Mouse    74 AAALGHHHHPGHVGSYSSAAFNSTRDFLFRNR----GFGDAAAAASAQHSLFAASAGGFGGPHGH 134

  Fly   108 --AADSMLFSGFPAQAAELGSGFGQHPFHSHHH--HHQMRMGMA-DAYAAGHPYNHHGNFPTAAV 167
              ||..:||||...|||.          |:..:  :.|||:|.: |.|.....|   |...:...
Mouse   135 TDAAGHLLFSGLHEQAAG----------HASPNVVNGQMRLGFSGDMYPRPEQY---GQVTSPRS 186

  Fly   168 HH---PVVH--HPSHHAMSAMHPAGAGAFLRYMRHQPASSASSVKQEMQCLWIDPDQPGLVPPGG 227
            .|   |.:|  .|.:..|:|.|  |||||.|||| ||      :|||:.|.||:|:|  |..|
Mouse   187 EHYAAPQLHGYGPMNVNMAAHH--GAGAFFRYMR-QP------IKQELICKWIEPEQ--LANP-- 238

  Fly   228 RKTCNKVFHSMHEIVTHLTVEHVGGPECTTHACFWVGCSRNGRPFKAKYKLVNHIRVHTGEKPFA 292
            :|:|||.|.:|||:|||:|||||||||.:.|.|||..|.|.|:|||||||||||||||||||||.
Mouse   239 KKSCNKTFSTMHELVTHVTVEHVGGPEQSNHICFWEECPREGKPFKAKYKLVNHIRVHTGEKPFP 303

  Fly   293 CPHPGCGKVFARSENLKIHKRTHTGEKPFKCEHEGCDRRFANSSDRKKHSHVHTSDKPYNCRING 357
            ||.|||||||||||||||||||||||||||||.||||||||||||||||.|||||||||.|::
Mouse   304 CPFPGCGKVFARSENLKIHKRTHTGEKPFKCEFEGCDRRFANSSDRKKHMHVHTSDKPYLCKM-- 366

  Fly   358 CDKSYTHPSSLRKHMKVHGNVDEKSPSHGYDSEGEESSSSSIITGGAQTPPSTRLDGSAGSSSGV 422
            ||||||||||||||||||.:..:.|......|.|.|||:...|.......|:|  ...:.|||.|
Mouse   367 CDKSYTHPSSLRKHMKVHESSSQGSQPSPAASSGYESSTPPTIVSPTTDNPTT--SSMSPSSSAV 429

  Fly   423 SSLSGGSGIKSS 434
            ...:|.|.:.|:
Mouse   430 HHTAGHSALSSN 441

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
opa	NP_001368991.1	zf_ZIC	206..253	CDD:408166	27/46 (59%)
		C2H2 Zn finger	265..285	CDD:275368	16/19 (84%)
		SFP1	<287..373	CDD:227516	76/85 (89%)
		C2H2 Zn finger	293..315	CDD:275368	20/21 (95%)
		C2H2 Zn finger	323..345	CDD:275368	19/21 (90%)
		C2H2 Zn finger	353..375	CDD:275368	17/21 (81%)
Zic1	NP_001363870.1	zf_ZIC	219..264	CDD:408166	29/54 (54%)
		C2H2 Zn finger	276..296	CDD:275368	16/19 (84%)
		SFP1	<298..382	CDD:227516	76/85 (89%)
		C2H2 Zn finger	304..326	CDD:275368	20/21 (95%)
		C2H2 Zn finger	334..356	CDD:275368	19/21 (90%)
		C2H2 Zn finger	364..384	CDD:275368	17/21 (81%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	375..434		23/60 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	68	1.000	Domainoid score	I9677
eggNOG	1	0.900	-	-		E33208_3BCH8
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	339	1.000	Inparanoid score	I2352
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000467
OrthoInspector	1	1.000	-	-		otm43260
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19818
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4702
SonicParanoid	1	1.000	-	-		X217
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	10.080