Protein Alignment BMAL1 and ss

DIOPT Version :10

• Sequence 1: XP_016873227.1
• Gene: BMAL1 / 406
• HGNCID: 701
• Length: 674
• Species: Homo sapiens
• Sequence 2: NP_001163629.2
• Gene: ss / 41988
• FlyBaseID: FBgn0003513
• Length: 1015
• Species: Drosophila melanogaster
• Alignment Length: 629
• Identity: 139/629 - (22%)
• Similarity: 243/629 - (38%)
• Gaps: 167/629 - (26%)

Human    69 SSLGTSGVDCNRKRKGSSTDYQESMDTDKDDPHGRLEYTEHQGRIKNAREAHSQIEKRRRDKMNS 133
            |.|||......|:|.|.|..........|.:|                       .||.|:::|:
  Fly     2 SQLGTVYATKRRRRNGKSLKPPPKDGVTKSNP-----------------------SKRHRERLNA 43

Human   134 FIDELASLVPTCNAMSRKLDKLTVLRMAVQHMKTLR------------GATNPYTEAN------- 179
            .:|.||||:|....:..|||:|::||::|.:::|..            ....|:..|:
  Fly    44 ELDLLASLLPFEQNILSKLDRLSILRLSVSYLRTKSYFQVVMHKDKEDNGVLPHIHAHDGYRTRE 108

Human   180 ---YKPTFLSDDELKHLILRAADGFLFVVGCDRGKILFVSESVFKILNYSQNDLIGQSLFDYLHP 241
               ::...|..|    :.|:|.:|||.::.|: |::.|.:.|:...|.:.|:|::.||:::.:|.
  Fly   109 LGAFEHGLLDGD----MFLQALNGFLMILTCE-GEVFFATHSIESYLGFHQSDIVHQSVYELVHS 168

Human   242 KDIAKVKEQLSSSDTAPRERLIDAKTGLPVKTDITPGPSRLCSGARRSFFCRMKCNRPSVKVEDK 306
            :|..:::.||..:...|.:     .:.:.:...:.|..:..   ..|||..|.:|.
  Fly   169 EDREELQRQLLWNSFLPAD-----MSSMQLAETLAPDKALY---LERSFTVRFRCL--------- 216

Human   307 DFPSTCSKKKAD-RKSFCTIHSTGYLKSWPPTKMGLDEDNEPDNEGCNLSCLVAIGRLHSHVVP- 369
             ..:|....:.| |.....:|........||.                        .|.::..|
  Fly   217 -LDNTSGFLRLDIRGRIKVLHGQNRKTEEPPL------------------------ALFAYCTPF 256

Human   370 -QPVNGEIRVKSMEYVSRHAIDGKFVFVDQRATAILAYLPQELLGTSCYEYFHQDDIGHLAECHR 433
             .|...||..|...:.|:|.:|...|.:|||...||.|...||:....|:..|.||:.::|..|:
  Fly   257 GPPSLLEIPHKENMFKSKHKLDFSLVSMDQRGKHILGYADAELVNMGGYDLVHYDDLAYVASAHQ 321

Human   434 QVLQTREKITTNCYKFKIKDGSFITLR-SRWFSFMNPWTKEVEYIVSTNTVVLANVLEGGDPTFP 497
            ::|:|... ....|:::.|||.:..|: |....:.|   .:.::::.|:..::..  ||.|
  Fly   322 ELLKTGAS-GMIAYRYQKKDGEWQWLQTSSRLVYKN---SKPDFVICTHRQLMDE--EGHD---- 376

Human   498 QLTASPHSMD---SMLPSG--------EDSFVVGGPKRTHPTVPGIP---GGTRAGAGKIGRMIA 548
              .....:||   |.|.:|        .|..||  |..|.||...:|   ..||.     .|...
  Fly   377 --LLGKRTMDFKVSYLDTGLASTYFSEADQLVV--PPSTSPTAHALPPPVTPTRP-----NRRYK 432

Human   549 EEIMEIHRIRGSSPSSCGSS-PLNITSTPPPDASSPGGKKILNGGTP---------DIPSSGLLS 603
            .::.:.       .|:|.|. .|...:.|....:||.|.::   |:|         ..|::.:.:
  Fly   433 TQLRDF-------LSTCRSKRKLQQQNQPQTQQTSPLGGQV---GSPAPAVAVEYLPDPAAAVAA 487

Human   604 GQAQENPGY---PYSDSSSILGENPHIGIDMIDN-DQGSSSPSN 643
            ..:..||.|   ||:.::              || ..|||.|:|
  Fly   488 AYSNLNPMYTTSPYASAA--------------DNLYMGSSMPAN 517

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
BMAL1	XP_016873227.1	bHLH-PAS_ARNTL_PASD3	110..173	CDD:381444	18/74 (24%)
		PAS	192..251	CDD:214512	16/58 (28%)
		PAS_11	382..484	CDD:464214	28/102 (27%)
ss	NP_001163629.2	bHLH-PAS_spineless_like	24..87	CDD:381573	20/85 (24%)
		PAS	123..178	CDD:214512	16/55 (29%)
		PAS_3	282..366	CDD:430001	24/87 (28%)