Protein Alignment BMAL1 and Clk

DIOPT Version :10

• Sequence 1: XP_016873227.1
• Gene: BMAL1 / 406
• HGNCID: 701
• Length: 674
• Species: Homo sapiens
• Sequence 2: NP_001014576.1
• Gene: Clk / 38872
• FlyBaseID: FBgn0023076
• Length: 1027
• Species: Drosophila melanogaster
• Alignment Length: 611
• Identity: 155/611 - (25%)
• Similarity: 249/611 - (40%)
• Gaps: 167/611 - (27%)

Human    96 DKDDPHGRLEYTEHQGRIKNAREAHSQIEKRRRDKMNSFIDELASLVPTCNAMSRKLDKLTVLRM 160
            ||||....|           .|::.:..||:|||:.||.:::|::|:.|   .|||:||.|||:.
  Fly     7 DKDDTKSFL-----------CRKSRNLSEKKRRDQFNSLVNDLSALIST---SSRKMDKSTVLKS 57

Human   161 AVQHMKTLRGATNP----YTEANYKPTFLSDDELKHLILRAADGFLFVVGCDRGKILFVSESVFK 221
            .:..:|....||:.    ..:.::||.|||:||..||:|.:.|||:.|.. ..|.|.:.|||:..
  Fly    58 TIAFLKNHNEATDRSKVFEIQQDWKPAFLSNDEYTHLMLESLDGFMMVFS-SMGSIFYASESITS 121

Human   222 ILNYSQNDLIGQSLFDYLHPKDIAKVKEQLSSSDTAPRERLIDA-KTGLPVKTDITPGPSRLCSG 285
            .|.|...||...:::|..:..|               .|.|::. ....||   |.|..:.:.|.
  Fly   122 QLGYLPQDLYNMTIYDLAYEMD---------------HEALLNIFMNPTPV---IEPRQTDISSS 168

Human   286 ARRSFFCRMKCNRPSVKVEDKDFPSTCSKKKADRKSFCTIHSTGYLKSWPPTKMGLDED------ 344
            .:.:|:..::..               ..:|.|..::..:...||.::...|..|...:
  Fly   169 NQITFYTHLRRG---------------GMEKVDANAYELVKFVGYFRNDTNTSTGSSSEVSNGSN 218

Human   345 -----------NEPDNEGCNLSCLVAIGRLHSHVVPQPVNGEIRV---KSMEYVSRHAIDGKFVF 395
                       ..|:.|.......|..||:.:   ||.:. |:.:   .|.|:.|:|:::.||:|
  Fly   219 GQPAVLPRIFQQNPNAEVDKKLVFVGTGRVQN---PQLIR-EMSIIDPTSNEFTSKHSMEWKFLF 279

Human   396 VDQRATAILAYLPQELLGTSCYEYFHQDDIGHLAECHRQVLQTREKITTNC-YKFKIKDGSFITL 459
            :|.||..|:.|:|.|:||||.|:|:|.||:..:..||.::.||.|  ..:| |:|..|...:|.|
  Fly   280 LDHRAPPIIGYMPFEVLGTSGYDYYHFDDLDSIVACHEELRQTGE--GKSCYYRFLTKGQQWIWL 342

Human   460 RSRWFSFMNPWTKEVEYIVSTNTVV-LANVL-----EG--------------------------- 491
            ::.::...:.:..:.:|:|.|:.|| .|.||     ||
  Fly   343 QTDYYVSYHQFNSKPDYVVCTHKVVSYAEVLKDSRKEGQKSGNSNSITNNGSSKVIASTGTSSKS 407

Human   492 --GDPTFPQLTASPHSMDSMLPSGEDSFVVGGPKRTHPTVPGIPGGTRAGAGKIGRMIAEEIMEI 554
              ...|......|..::||.| .|.....:|  ..|..|.|.:.......|..:
  Fly   408 ASATTTLRDFELSSQNLDSTL-LGNSLASLG--TETAATSPAVDSSPMWSASAV----------- 458

Human   555 HRIRGSSPS-SCGSSPLNITSTPPPDASSPGGKKILNGGTPDIPSSGLLSGQAQENPGYPYSDSS 618
                  .|| ||..:||. ||.|   |||.|          :|.|:| :|.:|:.. .|.|::..
  Fly   459 ------QPSGSCQINPLK-TSRP---ASSYG----------NISSTG-ISPKAKRK-CYFYNNRG 501

Human   619 SILGENPHIGIDMIDNDQGSSSPSND 644
                           ||..|:|.|.|
  Fly   502 ---------------NDSDSTSMSTD 512

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
BMAL1	XP_016873227.1	bHLH-PAS_ARNTL_PASD3	110..173	CDD:381444	21/62 (34%)
		PAS	192..251	CDD:214512	18/58 (31%)
		PAS_11	382..484	CDD:464214	36/102 (35%)
Clk	NP_001014576.1	bHLH-PAS_dCLOCK	11..86	CDD:381578	25/88 (28%)
		PAS	93..153	CDD:214512	20/75 (27%)
		PAS_11	265..368	CDD:464214	37/104 (36%)