Protein Alignment BMAL1 and tai

DIOPT Version :10

• Sequence 1: XP_016873227.1
• Gene: BMAL1 / 406
• HGNCID: 701
• Length: 674
• Species: Homo sapiens
• Sequence 2: NP_001245949.1
• Gene: tai / 34242
• FlyBaseID: FBgn0041092
• Length: 2047
• Species: Drosophila melanogaster
• Alignment Length: 779
• Identity: 144/779 - (18%)
• Similarity: 254/779 - (32%)
• Gaps: 283/779 - (36%)

Human    63 PTDLLSSSLGTSGVDCNRKRKGSSTDYQESMDTDKDDPHGRLEYTEHQGRIKNAREAHSQIEKRR 127
            |....|::..|||....||     ||.:.::.               |.:|.....     ||||
  Fly   208 PISANSANSATSGRKIRRK-----TDSKVNLP---------------QSQINKCNN-----EKRR 247

Human   128 RDKMNSFIDELASLVPTCN----AMSRKLDKLTVLRMAVQHMKTL--RG---------------- 170
            |:..|.:|::|:.:: |.|    ..|.|.||..:|...|:..:.:  :|
  Fly   248 REAENGYIEQLSEIL-TLNKRGDMTSTKPDKAAILNQVVRTYREICDKGQNRDISSTSTNNNNST 311

Human   171 -ATNPYTEAN-----YKPTFLSD------------------------------------------ 187
             .||..|.:|     .||...|.
  Fly   312 TTTNNNTNSNNNNNTSKPQATSTRCSRCATDNCSIHPVQQGEVSSTEPPLPEPSLLLGQVPEISA 376

Human   188 --DELKHLILRAADGFLFVVGCDRGKILFVSESVFKILNYSQNDLIGQSLFDYLHPKDIAKVKEQ 250
              :.|:|.|  :..|::.:.....|.|...::::..::.|.:.:|..|.|:.||:..|.||::..
  Fly   377 YFEALEHYI--SGVGWVLLQVNANGIIESCTQNIRDLIGYEKQELYHQPLYMYLYSGDHAKLEPI 439

Human   251 L-------------SSSDTAPRERLIDAKTGLPVKTDITP-------------------GPSRLC 283
            :             |::::.|...  .|.|...|..|:..                   |.....
  Fly   440 INTMYNNPNGGNSNSANNSGPGGS--SAGTSAGVWGDLEELNNGNASQGSNSSGAGGLGGAGGAA 502

Human   284 SGARRSFFCRMKCNRPSVKVED----KDFPSTCSKKKADRKSFCTIHSTGYLKSW-------PPT 337
            :|.:||...:::     :.|:|    ....|.|.:|        .:..:|:...:       .|.
  Fly   503 AGKKRSISTKVR-----MLVKDTRTATQTSSNCEEK--------PLRQSGHQDKYEEVVLIAAPV 554

Human   338 KMGLDEDNEPDNEGCNLSCLVAIGR----------LHSHVVPQPVNGEIRVKSMEYVSRHAIDGK 392
            |         |:...:.|.|..|.|          :..||..||:.        :...:..|.||
  Fly   555 K---------DDADASSSVLCLITRPEDESPLEINIQQHVQQQPIE--------QMTFKLDIHGK 602

Human   393 FVFVDQRATAILAYLPQEL---LGTSCYEYFHQDDIGHLAECHRQVLQTREKITTN--------- 445
            .:.:|  .||:.....|.|   :|....:..|..|:..|....|.:   ::..:.|
  Fly   603 ILTLD--PTALREPFKQHLQTWVGRLWQDLCHPHDLSTLKSHLRDI---QDSASANSPGAGAGTS 662

Human   446 --CYKFKIKDGS---FITLRSRWFSFMNPWTKEVEYIVSTNTVV-------LANVLEG-GDPTFP 497
              ...|:::.|:   ::.:::....|:|....|.::|:|..|::       .:|...| |.....
  Fly   663 VVSRPFRLRLGAPDVYVHVKANSRLFLNQTPGEGDFIMSVQTLLNSENDMNSSNTGAGSGGLGLG 727

Human   498 QLTA---SPHSMDSMLPSGEDSFVVGGPKRTHPTVPGIPGGTRAGAGKIGRMIAEEIMEIHRIRG 559
            ||.|   ||....|:|.|              .::.|:.|||.:|:                  .
  Fly   728 QLCAMAPSPSLASSLLSS--------------LSMDGLHGGTGSGS------------------S 760

Human   560 SSPSSCGSSPLNITSTPPPDASSPGG---KKILNGGTPDIPSSGLLSG-------QAQENPGYPY 614
            |||::.|..|.::...........||   .:..:.|.| :.||.:::|       |.|:..|...
  Fly   761 SSPAASGMLPTHLLGGLVGGGQQGGGGNSTQTTSVGGP-LMSSAIINGTGLQQQQQQQQRSGASS 824

Human   615 SDSSS------------ILGENPHIGIDMIDNDQGSSSPSNDEAAMAVIMSLLEADAGLGGPVD 666
            |.|||            ...|:...|.|..:.|..:.|.|.:          |:...|:|...|
  Fly   825 SASSSANALVNAFTASPAPAEHSFYGSDTFEFDIAAHSSSFE----------LDPSGGVGAWTD 878

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
BMAL1	XP_016873227.1	bHLH-PAS_ARNTL_PASD3	110..173	CDD:381444	19/85 (22%)
		PAS	192..251	CDD:214512	14/58 (24%)
		PAS_11	382..484	CDD:464214	22/118 (19%)
tai	NP_001245949.1	bHLH_SF	239..291	CDD:469605	16/57 (28%)
		PAS	377..442	CDD:214512	15/66 (23%)
		PAS_11	590..711	CDD:464214	22/133 (17%)