Protein Alignment BMAL1 and Met

DIOPT Version :10

• Sequence 1: XP_016873227.1
• Gene: BMAL1 / 406
• HGNCID: 701
• Length: 674
• Species: Homo sapiens
• Sequence 2: NP_511126.2
• Gene: Met / 32114
• FlyBaseID: FBgn0002723
• Length: 716
• Species: Drosophila melanogaster
• Alignment Length: 732
• Identity: 161/732 - (21%)
• Similarity: 266/732 - (36%)
• Gaps: 226/732 - (30%)

Human    68 SSSLGTSGVDCNRKRKGSSTDYQESMDTDKDDPHGRLEYTEHQGRIKNAREAHSQIEKRRRDKMN 132
            :.|.|::|...:....||.:.       ...||             .|.|||.:..||:||||:|
  Fly     9 TGSTGSAGSTGSGSGSGSGSG-------SSSDP-------------ANGREARNLAEKQRRDKLN 53

Human   133 SFIDELASLVPTCNAMSRKLDKLTVLRMAVQHMKTL----RGATNPYTEANYKPTFLSDD---EL 190
            :.|.|||::||.....||:|||..|||.|...::..    :.|:....:...|.|.:|..   :|
  Fly    54 ASIQELATMVPHAAESSRRLDKTAVLRFATHGLRLQYVFGKSASRRRKKTGLKGTGMSASPVGDL 118

Human   191 KHLILRAADGFLFVVGC------DRGKILFVSESVFKILNYSQNDLIGQSLFDYLHPKDIAKVKE 249
            .:..|...|..:.::.|      ..|:|:.||.||.::|.:.|:||.||:|....||.|...:::
  Fly   119 PNPSLHLTDTLMQLLDCCFLTLTCSGQIVLVSTSVEQLLGHCQSDLYGQNLLQITHPDDQDLLRQ 183

Human   250 QL---------------------------------SSSDTAPRE------RL------IDAKTGL 269
            ||                                 |.||....|      ||      .|.....
  Fly   184 QLIPRDIETLFYQHQHHQQQGHNPQQHSTSTSASTSGSDLEEEEMETEEHRLGRQQGEADDDEDH 248

Human   270 PVKTDITPGPSRLCSGA---------RRSFFCRMKCNRPSVKVEDKDFPST--CSKKKAD---RK 320
            |.... ||.|.|:...|         ||.|..|:.  |.|.:.|     :|  ..:.|.|   |:
  Fly   249 PYNRR-TPSPRRMAHLATIDDRLRMDRRCFTVRLA--RASTRAE-----ATRHYERVKIDGCFRR 305

Human   321 SFCTIHSTGYLKSWPPTKMGLDEDNE------------------PDNEGC----------NLSCL 357
            |..:: :.|...::|.....:.....                  |.::..          |...|
  Fly   306 SDSSL-TGGAAANYPIVSQLIRRSRNNNMLAAAAAVAAEAATVPPQHDAIAQAALHGISGNDIVL 369

Human   358 VAIGR-LHSHVVPQPVNGEIRVK--------SMEYVSRHAIDGKFVFVDQRATAILAYLPQELLG 413
            ||:.| |.....|:...|.:.:.        .:||.:||.|||..:..|||...:..|:..|:..
  Fly   370 VAMARVLREERPPEETEGTVGLTIYRQPEPYQLEYHTRHLIDGSIIDCDQRIGLVAGYMKDEVRN 434

Human   414 TSCYEYFHQDDIGHLAECHRQVLQTREKITTNCYKFKIKDGSFITLRSRWFSFMNPWTKEVEYIV 478
            .|.:.:.|.||:..:....||:.........:||:...::|.||.|.::.|..::..:.:|...:
  Fly   435 LSPFCFMHLDDVRWVIVALRQMYDCNSDYGESCYRLLSRNGRFIYLHTKGFLEVDRGSNKVHSFL 499

Human   479 STNTVV---------------LANVLEGGDPT---FPQLTASP----------HSMDSMLPSGED 515
            ..||::               .:.:::...||   .|.|.||.          :.::::..|.:.
  Fly   500 CVNTLLDEEAGRQKVQEMKEKFSTIIKAEMPTQSSSPDLPASQAPQQLERIVLYLIENLQKSVDS 564

Human   516 SFVVGG-------------PKRT--------HPT-----VPGIPGGTRAGAGK----IGRMIAEE 550
            :..|||             |..|        .||     ||..|...::...|    :....|.:
  Fly   565 AETVGGQGMESLMDDGYSSPANTLTLEELAPSPTPALALVPPAPSSVKSSISKSVSVVNVTAARK 629

Human   551 IMEIH---------RIRGSSPSSCG-----SSPLNITSTPPPDASSPGGKKILNGGTPDIPSSGL 601
            ..:.|         :::..:.|:.|     ||.|:...|    ||.     ||:      |:|.|
  Fly   630 FQQEHQKQRERDREQLKERTNSTQGVIRQLSSCLSEAET----ASC-----ILS------PASSL 679

Human   602 LSGQAQENPGYPYSDSS 618
            .:.:|.:.|. |:|::|
  Fly   680 SASEAPDTPD-PHSNTS 695

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
BMAL1	XP_016873227.1	bHLH-PAS_ARNTL_PASD3	110..173	CDD:381444	27/66 (41%)
		PAS	192..251	CDD:214512	19/64 (30%)
		PAS_11	382..484	CDD:464214	28/101 (28%)
Met	NP_511126.2	bHLH_PAS	38..89	CDD:381397	25/50 (50%)
		PAS	137..>186	CDD:238075	17/48 (35%)
		PAS_11	401..510	CDD:464214	28/108 (26%)