DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Gmppb and EIF2B5

DIOPT Version :10

Sequence 1:NP_649498.1 Gene:Gmppb / 40599 FlyBaseID:FBgn0037279 Length:369 Species:Drosophila melanogaster
Sequence 2:NP_003898.2 Gene:EIF2B5 / 8893 HGNCID:3261 Length:721 Species:Homo sapiens


Alignment Length:439 Identity:88/439 - (20%)
Similarity:155/439 - (35%) Gaps:111/439 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly     8 GNGTR-----------ALILVGGYGTRLRPLTLSTPKPLVEFANKPILLHQLEALVDAGCRQVIL 61
            |.|.|           |:::...:..|..|::...|:.|:..||..::.:.||.|...|.::..:
Human    29 GGGARGAEEEPPPPLQAVLVADSFDRRFFPISKDQPRVLLPLANVALIDYTLEFLTATGVQETFV 93

  Fly    62 AVSYRAEQMEKELKVEAK-----KLGVELIFSHET-EPLGTAGPLALAKTILAASSEPFFVLNSD 120
            ...::|.|:::.| :::|     .|.|..|.:.|. ..||.......||.::.:.   |.::..|
Human    94 FCCWKAAQIKEHL-LKSKWCRPTSLNVVRIITSELYRSLGDVLRDVDAKALVRSD---FLLVYGD 154

  Fly   121 VICDFP------------------------FKQLVQFHCNHGKEGTIVVT--------------- 146
            ||.:..                        ||:....|.....|..:||.               
Human   155 VISNINITRALEEHRLRRKLEKNVSVMTMIFKESSPSHPTRCHEDNVVVAVDSTTNRVLHFQKTQ 219

  Fly   147 ---------KVEEPSKYGV-VLYDENGC-------------IKNF-IEKPQEFVSNKINAGIYIF 187
                     .:.:.|..|| |.||...|             ..|| .:...:||     .|:.: 
Human   220 GLRRFAFPLSLFQGSSDGVEVRYDLLDCHISICSPQVAQLFTDNFDYQTRDDFV-----RGLLV- 278

  Fly   188 NPSVL-DRIEVKPTSIEKEVFPEMTQQQELYAMDLTGFWMDIGQPK----DFLTGMCLYLSSLRQ 247
            |..:| ::|.:..|:.|................|:...|:....|:    |..|..|.:      
Human   279 NEEILGNQIHMHVTAKEYGARVSNLHMYSAVCADVIRRWVYPLTPEANFTDSTTQSCTH------ 337

  Fly   248 KQSPKLYTGPGV-VG-------NVLVDPTAKIGEGCRIGPNVTIGPDVVIEDGVCIKRSTILKGA 304
             ....:|.||.| :|       |||:.....||..|.| .|..|||...|.|.|.:.::.:.:|.
Human   338 -SRHNIYRGPEVSLGHGSILEENVLLGSGTVIGSNCFI-TNSVIGPGCHIGDNVVLDQTYLWQGV 400

  Fly   305 IVRSHSWLDSCIVGWRSTVGRWVRIEGITVLGEDVIVKDELYINGGQVL 353
            .|.:.:.:...::...:.|...|.::..:||...|:|...:.:..|.|:
Human   401 RVAAGAQIHQSLLCDNAEVKERVTLKPRSVLTSQVVVGPNITLPEGSVI 449

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GmppbNP_649498.1 M1P_guanylylT_B_like_N 12..242 CDD:133047 57/314 (18%)
LbetaH 264..343 CDD:469633 20/78 (26%)
EIF2B5NP_003898.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..40 3/10 (30%)
eIF-2B_epsilon_N 43..257 CDD:133040 40/217 (18%)
LbH_eIF2B_epsilon 361..439 CDD:100061 20/78 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 444..483 2/6 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 523..547
W2_eIF2B_epsilon 548..711 CDD:211396
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.