Protein Alignment Gmppb and GCD1

DIOPT Version :10

• Sequence 1: NP_649498.1
• Gene: Gmppb / 40599
• FlyBaseID: FBgn0037279
• Length: 369
• Species: Drosophila melanogaster
• Sequence 2: NP_014903.1
• Gene: GCD1 / 854434
• SGDID: S000005786
• Length: 578
• Species: Saccharomyces cerevisiae
• Alignment Length: 499
• Identity: 91/499 - (18%)
• Similarity: 165/499 - (33%)
• Gaps: 186/499 - (37%)

  Fly    20 YGTRLRPLTLSTPKPLVEFANKPILLHQLEALVDAGCRQV-ILAVSYRAEQMEKELK--VEAKKL 81
            :.|||       ||.|:...|:|::.:.|:....|..::: ::|.....|.:|..|.  :..:|.
Yeast    60 HSTRL-------PKALLPIGNRPMIEYVLDWCDQADFKEISVVAPVDEIELIESGLTSFLSLRKQ 117

  Fly    82 GVELIFS---------HETEP---------LGTAGPLALAKTILAASSEPFFVLNSDVICDFPFK 128
            ..|||:.         |..:|         ..:.|. :|.|.:|...:..|.:|..|.:.|.|.:
Yeast   118 QFELIYKALSNSNHSHHLQDPKKINFIPSKANSTGE-SLQKELLPRINGDFVILPCDFVTDIPPQ 181

  Fly   129 QLV-QF------------HCNHGKEGTI---------------VVTKVEEPSKYGVVL--YDENG 163
            .|| ||            :..:..:.:|               |.::.|:..:..::|  |.:..
Yeast   182 VLVDQFRNRDDNNLAMTIYYKNSLDSSIDKKQQQKQKQQQFFTVYSENEDSERQPILLDVYSQRD 246

  Fly   164 CIK------------NFIEKPQEFVSNK-INAGIYIFNPSVLDRIEVKPTSIE-----KEVFPEM 210
            ..|            |:   |...||.| :|:.||..:..:...:::.|.|:.     |:.|...
Yeast   247 VTKTKYLQIRSHLLWNY---PNLTVSTKLLNSFIYFCSFELCQLLKLGPQSMSRQASFKDPFTGN 308

  Fly   211 TQQQELYAMD-----------------------------------------LTGFWMDIGQ---- 230
            .|||.....|                                         |:..:.|:.:
Yeast   309 QQQQNPPTTDDDEDRNHDDDDDYKPSATSIQPTYFKKKNDLILDPINCNKSLSKVFRDLSRRSWQ 373

  Fly   231 -------------PKDFL----TGMCLYLSSLR---QKQSPKLYT------GPGVVGNVLVDP-- 267
                         |.:.|    ..:..|:.:.|   :.:|..::|      ...:..:.:|||
Yeast   374 HSKPREPIGIFILPNETLFIRANNLNAYMDANRFVLKIKSQTMFTKNIQIQSAAIGADAIVDPKC 438

  Fly   268 ---------------TAKIGEGCRIG-----PNVTIGPDVVIEDGVCIKRSTILKGAIVRSHSWL 312
                           .|.||..||:.     |.|.:|.:|::|:  ||    |...|.:.|...|
Yeast   439 QISAHSNVKMSVLGTQANIGSRCRVAGSLLFPGVHLGDEVILEN--CI----IGPMAKIGSKCKL 497

  Fly   313 DSCIVGWRSTVGRWVRIEGITVLG-------EDVIVKDELYING 349
            .:|.:.....|......:|.|:..       ||.::.|:..|.|
Yeast   498 SNCYIEGHYVVEPKNNFKGETLANVYLDEDEEDELIYDDSVIAG 541

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gmppb	NP_649498.1	M1P_guanylylT_B_like_N	12..242	CDD:133047	59/352 (17%)
		LbetaH	264..343	CDD:469633	25/107 (23%)
GCD1	NP_014903.1	eIF-2B_gamma_N	3..285	CDD:133041	47/235 (20%)
		LbH_eIF2B_gamma_C	433..513	CDD:100057	21/85 (25%)