DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1129 and GCD6

DIOPT Version :9

Sequence 1:	NP_001189177.2	Gene:	CG1129 / 40599	FlyBaseID:	FBgn0037279	Length:	369	Species:	Drosophila melanogaster
Sequence 2:	NP_010497.3	Gene:	GCD6 / 851797	SGDID:	S000002619	Length:	712	Species:	Saccharomyces cerevisiae

Alignment Length:	408	Identity:	98/408 - (24%)
Similarity:	162/408 - (39%)	Gaps:	85/408 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 RALILVGGYGTRLRPLTLSTPKPLVEFANKPILLHQLEALVDAGCRQVILAVSYRAEQMEKELKV 76
            :|::|...|.||..|||...|:.|:..||.|::.:.||.|..||..:|.|..|..|.|:...::.
Yeast    28 QAVVLTDSYETRFMPLTAVKPRCLLPLANVPLIEYTLEFLAKAGVHEVFLICSSHANQINDYIEN 92

  Fly    77 EAKKL-----GVELIFSHETEPLGTAGPLALAKTILAASSEPFFVLNSDVICDFPFKQLVQFH-- 134
            ....|     .:..|.|.|....|........:.|:...   |.:::.||:.:..|.::::||
Yeast    93 SKWNLPWSPFKITTIMSPEARCTGDVMRDLDNRGIITGD---FILVSGDVLTNIDFSKMLEFHKK 154

  Fly   135 -----CNH------GKEGTIVVTKVEEPSKYGVVLYDENGCI------------KNFIEKPQEFV 176
                 .:|      .|..|...|:..||:.: |:....:.||            |..|:...|.:
Yeast   155 MHLQDKDHISTMCLSKASTYPKTRTIEPAAF-VLDKSTSRCIYYQDLPLPSSREKTSIQIDPELL 218

  Fly   177 SNKINAGIYIFNPSVLD-RIEVKPTSIEKEVFPEMTQQQEL--------YAMDLTG--------- 223
            .   |...::....::| ||:: .||....:|.|....|.|        .:.|:.|
Yeast   219 D---NVDEFVIRNDLIDCRIDI-CTSHVPLIFQENFDYQSLRTDFVKGVISSDILGKHIYAYLTD 279

  Fly   224 -------FWM---DIGQPKDFLTGMCLYL---SSLRQKQ-----SPKLYTGPGVV-------GN- 262
                   .|.   .|.|  |||...|..|   |:::..|     |..:|....||       |.
Yeast   280 EYAVRVESWQTYDTISQ--DFLGRWCYPLVLDSNIQDDQTYSYESRHIYKEKDVVLAQSCKIGKC 342

  Fly   263 VLVDPTAKIGEGCRIGPNVTIGPDVVIEDGVCIKRSTILKGAIVRSHSWLDSCIVGWRSTVGRWV 327
            ..:....|||||.:| .|..||.:..|.:.:.||.|.|....|:.::|.:|..::...:|:|..|
Yeast   343 TAIGSGTKIGEGTKI-ENSVIGRNCQIGENIRIKNSFIWDDCIIGNNSIIDHSLIASNATLGSNV 406

  Fly   328 RIEGITVLGEDVIVKDEL 345
            |:....::|.:|.:.|.:
Yeast   407 RLNDGCIIGFNVKIDDNM 424

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1129	NP_001189177.2	GCD1	12..361	CDD:224129	98/408 (24%)
		M1P_guanylylT_B_like_N	12..242	CDD:133047	66/287 (23%)
		LbetaH	264..343	CDD:294107	23/78 (29%)
GCD6	NP_010497.3	eIF-2B_epsilon_N	27..243	CDD:133040	53/222 (24%)
		glgC	<256..408	CDD:179486	37/154 (24%)
		LbH_eIF2B_epsilon	344..422	CDD:100061	23/78 (29%)
		W2_eIF2B_epsilon	550..704	CDD:211396
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1208
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810