Protein Alignment Gmppb and gmppab

DIOPT Version :10

• Sequence 1: NP_649498.1
• Gene: Gmppb / 40599
• FlyBaseID: FBgn0037279
• Length: 369
• Species: Drosophila melanogaster
• Sequence 2: NP_956791.1
• Gene: gmppab / 393469
• ZFINID: ZDB-GENE-040426-1550
• Length: 422
• Species: Danio rerio
• Alignment Length: 426
• Identity: 129/426 - (30%)
• Similarity: 205/426 - (48%)
• Gaps: 74/426 - (17%)

  Fly    12 RALILVGG--YGTRLRPLTLSTPKPLVEFANKPILLHQLEALVDAGCRQV-----ILAVSYRA-- 67
            :|:||:||  .|||.|||:...||||...|..|:|.|.:||     |.||     |:.:.:..
Zfish     3 KAIILIGGPQKGTRFRPLSFEVPKPLFPVAGVPMLQHHIEA-----CAQVPDMKEIMLIGFYQPN 62

  Fly    68 EQMEKELKVEAKKLGVELIFSHETEPLGTAGPL-ALAKTILAASSEPFFVLNSDVICDFPFKQLV 131
            :::.:.:....::..:.:.:..|...|||.|.: .....||:.....||::|:||..:||..:::
Zfish    63 DELNRFIYSAQQEFKIPIRYLQEFAALGTGGGIYHFRDQILSGGPAAFFLMNADVCSEFPLLEML 127

  Fly   132 QFHCNHGKE--GTIVVTKVE--EPSKYGVVLYD-ENGCIKNFIEKPQEFVSNKINAGIYIFNPSV 191
            |||..||:.  |.::.|...  :...||.::.: |...:.:|:|||..|||:.||.|||:|.|.:
Zfish   128 QFHRQHGENHCGVLLGTTANRTQSLNYGCIVENHETNEVLHFVEKPSTFVSDIINCGIYLFTPDI 192

  Fly   192 L------------DRIEVKPT---------SIEKEVFPEMTQQQELYAMDLTGFWMDIGQPKDFL 235
            .            ::|:.:.|         .:|:::|..:..|::|:......||..|......:
Zfish   193 FAHIGKVFQRNQQEKIQEELTHGRQMPEVVRLEQDIFTALAGQKKLFVYKTQHFWSQIKSAGSAI 257

  Fly   236 TGMCLYLSSLRQKQSPKLYTG----PGVVGNVLVDPTAKIGEGCRIGPNVTIGPDVVIEDGVCIK 296
            ....|||....|....:|.|.    |.:.|:|.:.|||.|.....:||||:||..|.|..||.::
Zfish   258 YASRLYLKQYHQTHPERLATNQGGTPKITGDVYIHPTANIDPSAVLGPNVSIGKGVTIGGGVRVR 322

  Fly   297 RSTILKGAIVRSHSWLDSCIVGWRSTVGRWVRIEG----------------------------IT 333
            .|.||.||:::.|..:.:.||||.||||:|.|:||                            ||
Zfish   323 ESIILHGAVLQDHCCVLNSIVGWDSTVGKWARVEGTPSDPNPNDPYAKIDSETLFRDGGLTPSIT 387

  Fly   334 VLGEDVIVKDELYINGGQVLPHKSIAASVPEPQIIM 369
            :||.:|.:..|:.|....|||||.:..|. :.|||:
Zfish   388 ILGCNVNIPSEVIIRNSIVLPHKDLNRSF-KNQIIL 422

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gmppb	NP_649498.1	M1P_guanylylT_B_like_N	12..242	CDD:133047	73/265 (28%)
		LbetaH	264..343	CDD:469633	37/106 (35%)
gmppab	NP_956791.1	Substrate-binding domain. /evidence=ECO:0000250|UniProtKB:Q96IJ6	2..253		72/254 (28%)
		M1P_guanylylT_A_like_N	4..263	CDD:133050	72/263 (27%)
		Hexapeptide repeat domain. /evidence=ECO:0000250|UniProtKB:Q96IJ6	275..422		52/147 (35%)
		LbetaH	291..357	CDD:469633	30/65 (46%)
		C-loop. /evidence=ECO:0000250|UniProtKB:Q96IJ6	358..386		0/27 (0%)