DRSC/TRiP Functional Genomics Resources

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Protein Alignment Gmppb and eIF2Bepsilon

DIOPT Version :10

Sequence 1:NP_649498.1 Gene:Gmppb / 40599 FlyBaseID:FBgn0037279 Length:369 Species:Drosophila melanogaster
Sequence 2:NP_569961.2 Gene:eIF2Bepsilon / 31156 FlyBaseID:FBgn0023512 Length:669 Species:Drosophila melanogaster


Alignment Length:469 Identity:82/469 - (17%)
Similarity:161/469 - (34%) Gaps:145/469 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly    12 RALILVGGYGTRLRPLTLSTPKPLVEFANKPILLHQLEALVDAGCRQVILAVS-YRA---EQMEK 72
            :|:::........:||:......|:...|..:|.:.|.||..:|..:|.:..| ||:   |.:..
  Fly    10 QAVLIADNNVWNFKPLSDEGSTALLPLVNVRMLDYALMALNRSGVEEVFVYTSLYRSSIREHIRA 74

  Fly    73 ELKVEAK---KLGVELIFSHETEPLGTAGPLALAKTILAASSEPFFVLNSDVICDFPFKQLVQFH 134
            .:..:|.   |:.|.:|........|.|......|.::...   |.:|.:|.:.:...:.:::.|
  Fly    75 GIATDAAWSFKMTVHVIGGEGCRCFGDAMRDLDNKALIRGH---FILLGADTVTNADLRPVLEQH 136

  Fly   135 -------------------CNHGKEGTIVVTKVE----------------EPSKYGVVL--YDEN 162
                               .|:.:.|..|:..|:                :.::|.:.|  :..|
  Fly   137 KRQAKFDKGTAATLVFKECANNVRTGNEVLIAVDRRNDRLHYHQRLRMHHKENRYQLPLDVFLGN 201

  Fly   163 GCIKNFIEKPQEFVSNKINAGIYIFNPSVL----DRIE-------VKPTSIEKEVFPEMT----- 211
            .|:        ....|.::..|.|.:||:|    |..:       |:...|.:|:.....     
  Fly   202 SCV--------ALHHNLLDPQIAIGSPSMLSLFNDNFDFQTRDDFVRGLLINEELLDSRIYVALL 258

  Fly   212 ------------QQQELYAMDLTGFWM-----DIGQPKDFLTGMCLYLSSLRQK---QSPKLYTG 256
                        ...:|.:.|:...|.     |||            |..|:|:   ....:|..
  Fly   259 PAAQYAHKVNNWPAYQLVSRDIINRWAYPFVPDIG------------LYKLQQEYVFHKDNIYKS 311

  Fly   257 P-------GVVGNVLVD-----------PTAKIGEGCRIGPNVTIG-----PDVVIEDGVCIKRS 298
            |       .::.||:::           ..:.||..||||.|..:.     .||.:.|...::..
  Fly   312 PEAHVSKVALLQNVVIEAGSHVDSGSVISDSVIGANCRIGKNCRLTNAFLMADVTVMDNCRLEHC 376

  Fly   299 TILKGAIVRSHSWLDS-CIVGWRSTVGRWVRIEGITVLGEDVIVK--------DELYINGGQVLP 354
            .:.:|||:.....:.: |::|.:|.      :.....|.:.:|.:        ||:.:....:.|
  Fly   377 VVGEGAIINEDCDVSAGCVLGAKSV------LPAKKTLAKTLITRTPSRRRSDDEVVVELKSIGP 435

  Fly   355 HKSIAASV----PE 364
            |..|.:.:    ||
  Fly   436 HAYIVSDLTTGDPE 449

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GmppbNP_649498.1 M1P_guanylylT_B_like_N 12..242 CDD:133047 50/306 (16%)
LbetaH 264..343 CDD:469633 18/103 (17%)
eIF2BepsilonNP_569961.2 eIF-2B_epsilon_N 9..223 CDD:133040 39/223 (17%)
LbetaH 326..397 CDD:469633 14/70 (20%)
W2_eIF2B_epsilon 499..659 CDD:211396
Blue background indicates that the domain is not in the aligned region.

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