Protein Alignment Gmppb and GMPPA

DIOPT Version :10

• Sequence 1: NP_649498.1
• Gene: Gmppb / 40599
• FlyBaseID: FBgn0037279
• Length: 369
• Species: Drosophila melanogaster
• Sequence 2: XP_047299979.1
• Gene: GMPPA / 29926
• HGNCID: 22923
• Length: 478
• Species: Homo sapiens
• Alignment Length: 477
• Identity: 135/477 - (28%)
• Similarity: 206/477 - (43%)
• Gaps: 120/477 - (25%)

  Fly    12 RALILVGG--YGTRLRPLTLSTPKPLVEFANKPILLHQLEALVDA-GCRQVILAVSYRA-EQMEK 72
            :|:||:||  .|||.|||:...||||...|..|::.|.:||.... |.::::|...|:. |.:.:
Human     3 KAVILIGGPQKGTRFRPLSFEVPKPLFPVAGVPMIQHHIEACAQVPGMQEILLIGFYQPDEPLTQ 67

  Fly    73 ELKVEAKKLGVELIFSHETEPLGTAGPL-ALAKTILAASSEPFFVLNSDVICDFPFKQLVQFHCN 136
            .|:...::..:.:.:..|..||||.|.| .....|||.|.|.|||||:||..|||...:::.|..
Human    68 FLEAAQQEFNLPVRYLQEFAPLGTGGGLYHFRDQILAGSPEAFFVLNADVCSDFPLSAMLEAHRR 132

  Fly   137 HGKEGTIVVTKVE--EPSKYGVVLYD-ENGCIKNFIEKPQEFVSNKINAGIYIFNPSVLDRI--- 195
            ......::.|...  :...||.::.: :...:.:::|||..|:|:.||.|||:|:|..|..:
Human   133 QRHPFLLLGTTANRTQSLNYGCIVENPQTHEVLHYVEKPSTFISDIINCGIYLFSPEALKPLRDV 197

  Fly   196 ---------------EVKP--------TSIEKEVFPEMTQQQELYAMDLTGFWMDIGQPKDFLTG 237
                           |..|        ..:|::||..:..|.::|.....|.|..|......|..
Human   198 FQRNQQDGQFCLALGEDSPGLWPGAGTIRLEQDVFSALAGQGQIYVHLTDGIWSQIKSAGSALYA 262

  Fly   238 MCLYLSS------------------LRQKQS---PKLY-----TGPG------------------ 258
            ..||||.                  :|..|.   |.|:     :.||
Human   263 SRLYLSRYQDTHPERLAKHTPGGPWIRGTQPAPIPNLWLPPQPSEPGFLTSSPELKPQSLPLPDQ 327

  Fly   259 -------------VVGNVLVDPTAKIGEGCRIGPNVTIGPDVVIEDGVCIKRSTILKGAIVRSHS 310
                         ::|||.:.||||:.....:||||:||..|.:.:||.::.|.:|.||.::.|:
Human   328 IRFGIFAPRASLLLLGNVYIHPTAKVAPSAVLGPNVSIGKGVTVGEGVRLRESIVLHGATLQEHT 392

  Fly   311 WLDSCIVGWRSTVGRWVRIEG----------------------------ITVLGEDVIVKDELYI 347
            .:...||||.||||||.|:||                            ||:||..|.:..|:.|
Human   393 CVLHSIVGWGSTVGRWARVEGTPSDPNPNDPRARMDSESLFKDGKLLPAITILGCRVRIPAEVLI 457

  Fly   348 NGGQVLPHKSIAASVPEPQIIM 369
            ....|||||.::.|... |||:
Human   458 LNSIVLPHKELSRSFTN-QIIL 478

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gmppb	NP_649498.1	M1P_guanylylT_B_like_N	12..242	CDD:133047	76/263 (29%)
		LbetaH	264..343	CDD:469633	36/106 (34%)
GMPPA	XP_047299979.1	M1P_guanylylT_A_like_N	4..266	CDD:133050	75/261 (29%)
		LbetaH	347..413	CDD:469633	29/65 (45%)