DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1129 and GMPPB

DIOPT Version :9

Sequence 1:	NP_001189177.2	Gene:	CG1129 / 40599	FlyBaseID:	FBgn0037279	Length:	369	Species:	Drosophila melanogaster
Sequence 2:	NP_037466.3	Gene:	GMPPB / 29925	HGNCID:	22932	Length:	387	Species:	Homo sapiens

Alignment Length:	386	Identity:	252/386 - (65%)
Similarity:	310/386 - (80%)	Gaps:	28/386 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 RALILVGGYGTRLRPLTLSTPKPLVEFANKPILLHQLEALVDAGCRQVILAVSYRAEQMEKELKV 76
            :||||||||||||||||||||||||:|.||||||||:|||..||...|||||||.::.:|||:|.
Human     2 KALILVGGYGTRLRPLTLSTPKPLVDFCNKPILLHQVEALAAAGVDHVILAVSYMSQVLEKEMKA 66

  Fly    77 EAKKLGVELIFSHETEPLGTAGPLALAKTILAASSEPFFVLNSDVICDFPFKQLVQFHCNHGKEG 141
            :.::||:.:..|||.||||||||||||:.:|:.:::|||||||||||||||:.:||||.:||:||
Human    67 QEQRLGIRISMSHEEEPLGTAGPLALARDLLSETADPFFVLNSDVICDFPFQAMVQFHRHHGQEG 131

  Fly   142 TIVVTKVEEPSKYGVVLYD-ENGCIKNFIEKPQEFVSNKINAGIYIFNPSVLDRIEVKPTSIEKE 205
            :|:|||||||||||||:.: :.|.|..|:||||.|||||||||:||.:|:||.||:::|||||||
Human   132 SILVTKVEEPSKYGVVVCEADTGRIHRFVEKPQVFVSNKINAGMYILSPAVLQRIQLQPTSIEKE 196

  Fly   206 VFPEMTQQQELYAMDLTGFWMDIGQPKDFLTGMCLYLSSLRQKQSPKLYTGPGVVGNVLVDPTAK 270
            |||.|.::.:||||:|.||||||||||||||||||:|.||||||..:|.:|||:||||||||:|:
Human   197 VFPIMAKEGQLYAMELQGFWMDIGQPKDFLTGMCLFLQSLRQKQPERLCSGPGIVGNVLVDPSAR 261

  Fly   271 IGEGCRIGPNVTIGPDVVIEDGVCIKRSTILKGAIVRSHSWLDSCIVGWRSTVGRW--------- 326
            ||:.|.|||||::||.||:||||||:|.|:|:.|.:||||||:|||||||..||:|
Human   262 IGQNCSIGPNVSLGPGVVVEDGVCIRRCTVLRDARIRSHSWLESCIVGWRCRVGQWVSLWAGLGG 326

  Fly   327 ------------------VRIEGITVLGEDVIVKDELYINGGQVLPHKSIAASVPEPQIIM 369
                              ||:|.:|||||||||.||||:||..|||||||..|||||:|||
Human   327 ERGGECACLPDKAYPLLEVRMENVTVLGEDVIVNDELYLNGASVLPHKSIGESVPEPRIIM 387

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1129	NP_001189177.2	GCD1	12..361	CDD:224129	244/376 (65%)
		M1P_guanylylT_B_like_N	12..242	CDD:133047	161/230 (70%)
		LbetaH	264..343	CDD:294107	55/105 (52%)
GMPPB	NP_037466.3	M1P_guanylylT_B_like_N	1..233	CDD:133047	161/230 (70%)
GMPPB	NP_037466.3	LbetaH	255..361	CDD:412191	55/105 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144410
Domainoid	1	1.000	327	1.000	Domainoid score	I1177
eggNOG	1	0.900	-	-		E1_COG1208
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5578
Inparanoid	1	1.050	531	1.000	Inparanoid score	I1217
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG61084
OrthoDB	1	1.010	-	-		D336231at33208
OrthoFinder	1	1.000	-	-		FOG0000664
OrthoInspector	1	1.000	-	-		oto88496
orthoMCL	1	0.900	-	-		OOG6_100460
Panther	1	1.100	-	-	LDO	PTHR22572
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R739
SonicParanoid	1	1.000	-	-		X1646
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800